2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P9802
    Anti-Spike-RBD Single Domain mAb
    Anti-Spike-RBD Single Domain mAb is a CHO cell derived Alpaca monoclonal VHH-huFc antibody, specifically binds to SARS-CoV-2 RBD with high affinity.
    Anti-Spike-RBD Single Domain mAb
  • HY-P9804
    Anti-MERS-2E6 mAb
    Anti-MERS-2E6 mAb (MERS-2E6; MERS Antibody-2E6), a human neutralizing antibody IgG1 (CHO expressed) that can compete for the binding of the virus Spike protein to the receptor (CD26), thereby inhibiting virus invasion into host cells.
    Anti-MERS-2E6 mAb
  • HY-P9805
    Anti-MERS-3A1 mAb
    Anti-MERS-3A1 mAb (MERS-3A1) is a human monoclonal IgG1 antibody with the high binding affinity produced in CHO cells. Anti-MERS-3A1 mAb bocks the binding of MERS-CoV spike protein to DPP4 receptor.
    Anti-MERS-3A1 mAb
  • HY-P9806
    Anti-MERS-D12 mAb
    Anti-MERS-D12 mAb (MERS-D12; MERS Antibody-D12) is a human monoclonal IgG1. Anti-MERS-D12 mAb binds directly to the DPP4 interacting region of the MERS-CoV Spike receptor binding domain (RBD) and effect neutralization by directly blocking receptor binding.
    Anti-MERS-D12 mAb
  • HY-105752
    Loflucarban 790-69-2
    Loflucarban (Fluonilid) is a potent antimycotic agent. Loflucarban can be used for the research of the ear infections.
    Loflucarban
  • HY-107218
    11-Hydroxysugiol 88664-08-8
    11-Hydroxysugiol regulates the SUMOylation of intracellular receptors by modulating RARα and vitamin D3 receptor (VDR).
    11-Hydroxysugiol
  • HY-121493
    TM2-115 1197196-47-6 98.37%
    TM2-115 inhibits malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death.
    TM2-115
  • HY-126604
    Pyranonigrin A 773855-65-5
    Pyranonigrin A is isolated and identified from Penicillium brocae MA-231. Pyranonigrin A shows potent activity against a broad spectrum of human-, aqua-, and plant-pathogens.
    Pyranonigrin A
  • HY-130626
    RSV/IAV-IN-1 2395007-77-7
    RSV/IAV-IN-1 (compound 14e) is a potent and dual inhibitor of RSV/IAV. RSV/IAV-IN-1 has lesser cytotoxicity than the clinical agent, Ribavirin. RSV/IAV-IN-1 has the potential for the research of RSV and/or IAV infections.
    RSV/IAV-IN-1
  • HY-130627
    RSV/IAV-IN-2 2395007-75-5
    RSV/IAV-IN-2 (compound 14c) is a potent and dual inhibitor of RSV/IAV. RSV/IAV-IN-2 has lesser cytotoxicity than the clinical agent, Ribavirin. RSV/IAV-IN-2 has the potential for the research of RSV and/or IAV infections.
    RSV/IAV-IN-2
  • HY-132191
    Pradimicin A 117704-65-1
    Pradimicin A (PRM-A) is a potent antifungal agent, with an MIC of 4 μg/mL against Candida rugosa. Pradimicin A has antiviral activities against CoV, HIV and other enveloped viruses. Pradimicin A shows aggregation property, and can recognize d-Man in the presence of Ca2+ ion.
    Pradimicin A
  • HY-138592
    7-Deaza-2',3'-dideoxyguanosine 111869-49-9 98.02%
    7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) is a 2′,3′-dideoxynucleoside 5′-triphosphate, which can inhibit HIV-1 reverse transcriptase with a Ki of 25 nM.
    7-Deaza-2',3'-dideoxyguanosine
  • HY-B0005S
    Toremifene-d6 citrate 1246833-71-5
    Toremifene-d6 (citrate) is the deuterium labeled Toremifene citrate. Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].
    Toremifene-d6 citrate
  • HY-B0370S
    Tolnaftate (D7) 1329835-64-4
    Tolnaftate-d7 is the deuterium labeled Tolnaftate. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent[1][2].
    Tolnaftate (D7)
  • HY-B0398S
    Nalidixic Acid-d5 1189467-36-4
    Nalidixic Acid-d5 is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1].
    Nalidixic Acid-d5
  • HY-B0847S
    Propiconazole-d7 1246818-14-3
    Propiconazole-d7 is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS)[1].
    Propiconazole-d7
  • HY-B1858S
    Isoprothiolane-d4 1715020-82-8
    Isoprothiolane-d4 is the deuterium labeled Isoprothiolane. Isoprothiolane is a systemic fungicide. Isoprothiolane is a rice blast controlling agent against the fungal disease of rice planty Pyvioutavia oryzae Cav[1][2].
    Isoprothiolane-d4
  • HY-113784R
    Thiocarlide (Standard) 910-86-1
    β-Cyclodextrin (Standard) is the analytical standard of β-Cyclodextrin. This product is intended for research and analytical applications. β-Cyclodextrin is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds. β-Cyclodextrin has often been used to enhance the solubility of agents. β-Cyclodextrin has anti-influenza virus H1N1 activities.
    Thiocarlide (Standard)
  • HY-130055R
    HQNO (Standard) 341-88-8
    HQNO (Standard) is the analytical standard of HQNO. This product is intended for research and analytical applications. HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].
    HQNO (Standard)
  • HY-13725AR
    Pirarubicin Hydrochloride (Standard) 95343-20-7
    Pirarubicin (Hydrochloride) (Standard) is the analytical standard of Pirarubicin (Hydrochloride). This product is intended for research and analytical applications. Pirarubicin Hydrochloride is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors.
    Pirarubicin Hydrochloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity