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Results for "

redox active

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Amyloid-β (1) Antibiotic (1) AP-1 (1) Apoptosis (4) Autophagy (1) Bacterial (3) Bcl-2 Family (1) Biochemical Assay Reagents (2) Caspase (1) COX (1) DNA/RNA Synthesis (1) Drug Metabolite (2) EGFR (1) Endogenous Metabolite (2) Fluorescent Dye (1) HIF/HIF Prolyl-Hydroxylase (1) IKZF Family (1) Interleukin Related (1) Keap1-Nrf2 (3) Lipoxygenase (1) MMP (1) mTOR (1) NADPH Oxidase (1) NF-κB (4) NO Synthase (1) PARP (1) Phosphatase (2) Reactive Oxygen Species (10) TNF Receptor (1) Transferrin Receptor (1) TrxR (1) VEGFR (1) Zinc Finger Protein (1) α-synuclein (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (8) Metabolic Disease (5) Neurological Disease (6)

By Targets:

Akt (1)

Amyloid-β (1)

Antibiotic (1)

AP-1 (1)

Apoptosis (4)

Autophagy (1)

Bacterial (3)

Bcl-2 Family (1)

Biochemical Assay Reagents (2)

Caspase (1)

COX (1)

DNA/RNA Synthesis (1)

Drug Metabolite (2)

EGFR (1)

Endogenous Metabolite (2)

Fluorescent Dye (1)

HIF/HIF Prolyl-Hydroxylase (1)

IKZF Family (1)

Interleukin Related (1)

Keap1-Nrf2 (3)

Lipoxygenase (1)

MMP (1)

mTOR (1)

NADPH Oxidase (1)

NF-κB (4)

NO Synthase (1)

PARP (1)

Phosphatase (2)

Reactive Oxygen Species (10)

TNF Receptor (1)

Transferrin Receptor (1)

TrxR (1)

VEGFR (1)

Zinc Finger Protein (1)

α-synuclein (2)

By Research Areas:

Cancer (6)

Cardiovascular Disease (1)

Infection (3)

Inflammation/Immunology (8)

Metabolic Disease (5)

Neurological Disease (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1106

Tetrahydroxyquinone Tetrahydroxy-1,4-benzoquinone; Tetrahydroxybenzoquinone	Reactive Oxygen Species Apoptosis	Cancer
Tetrahydroxyquinone (Tetrahydroxy-1,4-benzoquinone), a primitive anticataract agent, is a redox active benzoquinone. Tetrahydroxyquinone can take part in a redox cycle with semiquinone radicals, leading to the formation of reactive oxygen species (ROS) .

HY-B1106A

Tetrahydroxyquinone monohydrate Tetrahydroxy-1,4-benzoquinone monohydrate; Tetrahydroxybenzoquinone monohydrate	Reactive Oxygen Species Apoptosis	Cancer
Tetrahydroxyquinone monohydrate (Tetrahydroxy-1,4-benzoquinone monohydrate), a primitive anticataract agent, is a redox active benzoquinone. Tetrahydroxyquinone monohydrate can take part in a redox cycle with semiquinone radicals, leading to the formation of reactive oxygen species (ROS) .

HY-W012145

TMPD dihydrochloride	Others	Metabolic Disease
TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases . TMPD dihydrochloride is also a complex IV substrate .

HY-122131

XTT sodium	Biochemical Assay Reagents	Others
XTT (sodium) is used to assess cell viability as a function of redox potential. Actively respiring cells convert the water-soluble XTT to a water-soluble, orange colored formazan product.

HY-19357

E3330 3 Publications Verification APX-3330	DNA/RNA Synthesis NF-κB AP-1 HIF/HIF Prolyl-Hydroxylase VEGFR Reactive Oxygen Species	Cardiovascular Disease Neurological Disease Cancer
E3330 (APX-3330) is a direct, orally active and selective inhibitor of *Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox* factor-1)** redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. E3330 shows anticancer activities .

HY-111278

Pyocyanin 1 Publications Verification Pyocyanine; Sanazin; Sanasin	Reactive Oxygen Species Bacterial Drug Metabolite Endogenous Metabolite	Infection Inflammation/Immunology
Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity .

HY-153978

GLX481369	NADPH Oxidase	Others
GLX481369 is a redox active substance. GLX481369 is a Nox4 inhibitor. GLX481369 has antioxidant effects .

HY-148766

VU661	Others	Metabolic Disease
VU661, a phenazine carboxamide, is a modulator of circadian rhythms to produce a period lengthening of the circadian rhythm. VU661 is a redox-active small molecule .

HY-N13292

Actinorhodin	Antibiotic Bacterial	Infection
Actinorhodin is a blue-pigmented, redox-active microbial secondary metabolite. Actinorhodin is a potent, bacteriostatic, pH-responsive antibiotic. Actinorhodin exhibits antimicrobial activity against Gram-positive bacteria .

HY-111278R

Pyocyanin (Standard) Pyocyanine (Standard); Sanazin (Standard); Sanasin (Standard)	Reactive Oxygen Species Bacterial Drug Metabolite Endogenous Metabolite	Infection Inflammation/Immunology
Pyocyanin (Standard) is the analytical standard of Pyocyanin. This product is intended for research and analytical applications. Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity[1][2][3][4].

HY-115832

Ap44mSe	Transferrin Receptor	Cancer
Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization .

HY-116749

Ethaselen BBSKE	TrxR	Cancer
Ethaselen (BBSKE) is an orally active, selective thioredoxin reductase (TrxR) inhibitor with IC₅₀s of 0.5 and 0.35 μM for the wild-type human TrxR1 and rat TrxR1, respectively. Ethaselen specifically binds to the unique selenocysteine-cysteine redox pair in the C-terminal active site of mammalian TrxR1. Ethaselen, an organoselenium compound, is a potent antitumor candidate that exerts potent inhibition on non-small cell lung cancer (NSCLC) by targeting TrxR .

HY-117048

PF-4191834 PF-04191834	Lipoxygenase	Inflammation/Immunology
PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC₅₀=229 nM), displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes, and is effective in inflammation and pain .

HY-125999

EPI-589	Reactive Oxygen Species	Neurological Disease
EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductase enzyme inhibitor and a free radical scavenger, with blood-brain barrier permeable and orally available. EPI-589 is a redox-active neuroprotectant that effectively delays the symptoms of motor neuron disease in wobbler mice. EPI-589 can be used in amyotrophic lateral sclerosis (ALS) research .

HY-N0513

Loganic acid	Reactive Oxygen Species Phosphatase NF-κB Keap1-Nrf2	Metabolic Disease Inflammation/Immunology
Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid inhibits NF-κB signaling pathway, activates Nrf2 signaling pathway, exhibits anti-inflammatory activity. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity. Loganic acid is orally active .

HY-120475

PBT434 ATH434	α-synuclein	Neurological Disease
PBT434 is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 has the potential for the research of Parkinson’s disease (PD) .

HY-N0513R

Loganic acid (Standard)	Reactive Oxygen Species Phosphatase NF-κB Keap1-Nrf2	Metabolic Disease Inflammation/Immunology
Loganic acid (Standard) is the analytical standard of Loganic acid. This product is intended for research and analytical applications. Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid inhibits NF-κB signaling pathway, activates Nrf2 signaling pathway, exhibits anti-inflammatory activity. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity. Loganic acid is orally active .

HY-125662A

BMX-001	Reactive Oxygen Species Apoptosis	Metabolic Disease
BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model. BMX-001 reduces apoptosis in human and murine islets. BMX-001 significantly improves static-glucose stimulated insulin secretion (sGSIS) responses in murine islets. BMX-001 can significantly restore euglycemia in murine islet studies in the presence of the MnSOD. BMX-001 reduces the generation of ROS in a murine islet isolation and culture model .

HY-120475A

PBT434 mesylate 1 Publications Verification ATH434 mesylate	α-synuclein	Neurological Disease
PBT434 methanesulfonate is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 methanesulfonate can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 methanesulfonate inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 methanesulfonate prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 methanesulfonate has the potential for the research of Parkinson’s disease (PD) .

HY-149246

Aβ-IN-6	Amyloid-β Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells. Aβ-IN-6 significantly induces Nrf2 nuclear translocation and hamperes Aβ oligomers formation. Aβ-IN-6 exerts a consistent neuroprotective effect by modulating the redox-sensitive signalling pathways in vivo oxidative stress model. Aβ-IN-6 is an orally active and has antiinflammatory, Antioxidant and Anti-oligomeric activity. Aβ-IN-6 has the potential for Alzheimer's disease (AD) research .

HY-W110927

Alizarin Red S Indicator (4.3-6.3), IND Maximum Cited Publications 7 Publications Verification	Biochemical Assay Reagents Fluorescent Dye	Others
Alizarin red S indicator (C.I. 58005) is a reductively active (quinone-based) anthraquinone dye that forms complexes with metal ions (such as zirconium, calcium) or boric acid to label calcium deposition and perform electrochemical sensing functions. Alizarin Red S undergoes reversible redox reactions (for electrochemical detection) and irreversible chelation (for bone staining). Alizarin Red S is mainly used in bone metabolism research (labeling mineralized tissue), sugar detection (boric acid-sugar competition system) and metal ion sensing (such as zirconium ion detection)， and can be used in osteoporosis and metabolic disease research .

HY-W016412

Coenzyme Q0 2 Publications Verification CoQ0	Apoptosis Autophagy EGFR Akt mTOR Caspase Bcl-2 Family Reactive Oxygen Species PARP COX NO Synthase TNF Receptor Interleukin Related MMP NF-κB	Neurological Disease Inflammation/Immunology Cancer
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .

HY-155539

Cisd2 agonist 2 1 Publications Verification	IKZF Family Zinc Finger Protein	Inflammation/Immunology
Cisd2 agonist 2 (compound 6) is a Cisd2 activator (EC₅₀=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout). Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters .

Cat. No.	Product Name	Type

HY-W110927

Alizarin Red S Indicator (4.3-6.3), IND 5+ Cited Publications	Indicators
Alizarin red S indicator (C.I. 58005) is a reductively active (quinone-based) anthraquinone dye that forms complexes with metal ions (such as zirconium, calcium) or boric acid to label calcium deposition and perform electrochemical sensing functions. Alizarin Red S undergoes reversible redox reactions (for electrochemical detection) and irreversible chelation (for bone staining). Alizarin Red S is mainly used in bone metabolism research (labeling mineralized tissue), sugar detection (boric acid-sugar competition system) and metal ion sensing (such as zirconium ion detection)， and can be used in osteoporosis and metabolic disease research .

Alizarin Red S Indicator (4.3-6.3), IND

5+ Cited Publications

Indicators

Alizarin red S indicator (C.I. 58005) is a reductively active (quinone-based) anthraquinone dye that forms complexes with metal ions (such as zirconium, calcium) or boric acid to label calcium deposition and perform electrochemical sensing functions. Alizarin Red S undergoes reversible redox reactions (for electrochemical detection) and irreversible chelation (for bone staining). Alizarin Red S is mainly used in bone metabolism research (labeling mineralized tissue), sugar detection (boric acid-sugar competition system) and metal ion sensing (such as zirconium ion detection)， and can be used in osteoporosis and metabolic disease research .

HY-W016412

Coenzyme Q0 2 Publications Verification CoQ0	Enzyme Substrates
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .

Coenzyme Q0

2 Publications Verification

CoQ0

Enzyme Substrates

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .

Pyocyanin 1 Publications Verification Pyocyanine; Sanazin; Sanasin	Microorganisms Source classification	Reactive Oxygen Species Bacterial Drug Metabolite Endogenous Metabolite
Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity .

Loganic acid	Cardiovascular Disease Structural Classification Iridoids Cornaceae Classification of Application Fields Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants Disease Research Fields	Reactive Oxygen Species Phosphatase NF-κB Keap1-Nrf2
Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid inhibits NF-κB signaling pathway, activates Nrf2 signaling pathway, exhibits anti-inflammatory activity. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity. Loganic acid is orally active .

Actinorhodin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Actinorhodin is a blue-pigmented, redox-active microbial secondary metabolite. Actinorhodin is a potent, bacteriostatic, pH-responsive antibiotic. Actinorhodin exhibits antimicrobial activity against Gram-positive bacteria .

Pyocyanin (Standard) Pyocyanine (Standard); Sanazin (Standard); Sanasin (Standard)	Microorganisms Source classification	Reactive Oxygen Species Bacterial Drug Metabolite Endogenous Metabolite
Pyocyanin (Standard) is the analytical standard of Pyocyanin. This product is intended for research and analytical applications. Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity[1][2][3][4].

Loganic acid (Standard)	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	Reactive Oxygen Species Phosphatase NF-κB Keap1-Nrf2
Loganic acid (Standard) is the analytical standard of Loganic acid. This product is intended for research and analytical applications. Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid inhibits NF-κB signaling pathway, activates Nrf2 signaling pathway, exhibits anti-inflammatory activity. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity. Loganic acid is orally active .

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