Isolation and biological evaluation of jatrophane diterpenoids from Euphorbia dendroides

J Nat Prod. 2011 Jul 22;74(7):1613-20. doi: 10.1021/np200241c.

Ivana S Aljancić ¹, Milica Pesić, Slobodan M Milosavljević, Nina M Todorović, Milka Jadranin, Goran Milosavljević, Dragan Povrenović, Jasna Banković, Nikola Tanić, Ivanka D Marković, Sabera Ruzdijić, Vlatka E Vajs, Vele V Tesević

Affiliations

Affiliation

1 Institute of Chemistry, Technology and Metallurgy, Center for Chemistry, University of Belgrade, Njegoševa 12, 11001 Belgrade, Serbia. aljancic@chem.bg.ac.rs

PMID: 21707046 DOI: 10.1021/np200241c

Abstract

From the Montenegrin spurge Euphorbia dendroides, seven new Diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human Cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multi-drug-resistant Cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.

Name
Email *

	Sorry, but the email address you supplied was invalid.