2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. XEN-2174

XEN-2174 is a noradrenaline transporter (NET) inhibitor. XEN-2174 inhibits the reuptake of noradrenaline through non-competitive inhibition, increasing the concentration of noradrenaline in the synaptic cleft, thereby activating α2-adrenergic receptor at the spinal level and exerting analgesic effects. XEN-2174 exhibits long-lasting analgesic effects in models of neuropathic pain and postoperative pain in rats. XEN-2174 can be used in pain research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

XEN-2174

XEN-2174 Chemical Structure

CAS No. : 701909-57-1

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XEN-2174 Related Antibodies

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Description

XEN-2174 is a noradrenaline transporter (NET) inhibitor. XEN-2174 inhibits the reuptake of noradrenaline through non-competitive inhibition, increasing the concentration of noradrenaline in the synaptic cleft, thereby activating α2-adrenergic receptor at the spinal level and exerting analgesic effects. XEN-2174 exhibits long-lasting analgesic effects in models of neuropathic pain and postoperative pain in rats. XEN-2174 can be used in pain research[1].

Molecular Weight

1404.66

Formula

C58H85N17O16S4
CAS No.
Sequence

{pGlu}-Gly-Val-Cys-Cys-Gly-Tyr-Lys-Leu-Cys-His-{Hyp}-Cys-NH2 (Disulfide bridge: Cys4-Cys13,Cys5-Cys10)
Sequence Shortening

{pGlu}-GVCCGYKLCH-{Hyp}-C-NH2 (Disulfide bridge: Cys4-Cys13,Cys5-Cys10)
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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XEN-2174 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XEN-2174701909-57-1XEN2174XEN 2174Adrenergic ReceptorBeta Receptorintrathecal administrationnorepinephrine reuptake inhibitorpharmacokineticspharmacodynamicsevoked paincerebrospinal fluidanalgesic efficacyclinical trialhealthy subjectsInhibitorinhibitorinhibit

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