2. PROTAC Immunology/Inflammation NF-κB MAPK/ERK Pathway
  3. Ligands for Target Protein for PROTAC IRAK NF-κB p38 MAPK
  4. UR241-2

UR241-2 is an IRAK4 inhibitor. UR241-2 suppresses IL-1–induced IRAK1/4 signaling, NF-κβ activation, and phosphorylation of p65 and p38. UR241-2 selectively inhibits leukemia stem cell clonogenicity. UR241-2 can serve as a ligand for target proteins for PROTAC, facilitating the development and design of PROTAC degraders for IRAK4. UR241-2 can be used in the research of acute myeloid leukemia.

For research use only. We do not sell to patients.

UR241-2

UR241-2 Chemical Structure

CAS No. : 2597345-07-6

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UR241-2 Related Antibodies

Top Publications Citing Use of Products

View All IRAK Isoform Specific Products:

View All Isoforms
IRAK1 IRAK4

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

UR241-2 is an IRAK4 inhibitor. UR241-2 suppresses IL-1–induced IRAK1/4 signaling, NF-κβ activation, and phosphorylation of p65 and p38. UR241-2 selectively inhibits leukemia stem cell clonogenicity. UR241-2 can serve as a ligand for target proteins for PROTAC, facilitating the development and design of PROTAC degraders for IRAK4. UR241-2 can be used in the research of acute myeloid leukemia[1].

IC50 & Target[1]

IRAK4

 

IRAK1

 

Molecular Weight

378.43

Formula

C20H22N6O2
CAS No.
SMILES

COC1=CC(N2CCNCC2)=CC=C1NC(C3=CC=CC(C4=NNC=C4)=N3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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UR241-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UR241-22597345-07-6Ligands for Target Protein for PROTACIRAKNF-κBp38 MAPKTarget Protein-binding MoietyInterleukin-1 receptor associated kinaseIL-1R associated kinaseNuclear factor-κBNuclear factor-kappaBacute myeloid leukemiaInhibitorinhibitorinhibit

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