2. GPCR/G Protein Neuronal Signaling
  3. GLP Receptor GCGR Neuropeptide Y Receptor
  4. TC2

TC2 is an efficient GIPR-preferring monomeric quadruple agonist that can respectively activate GIPR, GLP-1R, GcgR, and Y2R with IC50 values of 0.47, 2.1, 30, and 55 nM respectively. TC2 exhibits a significant GLP-1R preference, with a significant reduction in β-inhibitory protein 2 (βArr2) recruitment, while maintaining a strong cAMP signal. TC2 can be used for research on obesity and diabetes.

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TC2

TC2 Chemical Structure

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TC2 Related Antibodies

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NPY Y1 receptor NPY Y2 receptor NPY Y4 receptor NPY Y5 receptor

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Description

TC2 is an efficient GIPR-preferring monomeric quadruple agonist that can respectively activate GIPR, GLP-1R, GcgR, and Y2R with IC50 values of 0.47, 2.1, 30, and 55 nM respectively. TC2 exhibits a significant GLP-1R preference, with a significant reduction in β-inhibitory protein 2 (βArr2) recruitment, while maintaining a strong cAMP signal. TC2 can be used for research on obesity and diabetes[1].
Molecular Weight

6007.84

Formula

C279H435N67O80
Sequence

Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-{Tyr(AEEA-gGlu-C16 acid)}-Ser-Ile-Leu-Leu-Asp-Arg-Lys-Ala-Gln-Ala-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Leu-Arg-His-Tyr-Val-Asn-Trp-Leu-Thr-Arg-Gln-Arg-Tyr-NH2
Sequence Shortening

Y-{Aib}-QGTFTSD-{Tyr(AEEA-gGlu-C16 acid)}-SILLDRKAQAAFIEYLLEGGPSLRHYVNWLTRQRY-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TC2 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC2TC 2TC-2GLP ReceptorGCGRNeuropeptide Y ReceptorGlucagon ReceptorNPY receptorUnimolecular tetra-agonistG protein-coupled receptor (GPCR)Biased signaling (cAMP/β-arrestin)Metabolic homeostasisPeptide engineeringLipidation (protraction)DPP-4 resistanceScalable manufacturingInhibitorinhibitorinhibit

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