2. Immunology/Inflammation
  3. STING
  4. STING agonist-48

STING agonist-48 is a potent STING agonist that exhibits STING-dependent activity in vitro (EC50 = 4.02 μM). STING agonist-48 prefers to bind with the transmembrane domain (TMD) over the cytosolic cyclic dinucleotide (CDN) domain. STING agonist-48 shows adjuvant efficacy, enhancing IgG and Th1/Th2 cytokine responses in humanized STING mice. STING agonist-48 can be used for the study of inflammation-related diseases.

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STING agonist-48

STING agonist-48 Chemical Structure

CAS No. : 3027712-31-5

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STING agonist-48 Related Antibodies

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Description

STING agonist-48 is a potent STING agonist that exhibits STING-dependent activity in vitro (EC50 = 4.02 μM). STING agonist-48 prefers to bind with the transmembrane domain (TMD) over the cytosolic cyclic dinucleotide (CDN) domain. STING agonist-48 shows adjuvant efficacy, enhancing IgG and Th1/Th2 cytokine responses in humanized STING mice. STING agonist-48 can be used for the study of inflammation-related diseases[1].

In Vitro

STING agonist-48 (Compound 7k) (6.25-50 μM, 24 h) induces a dose-dependent increase in luciferase activity in THF-ISRE IRF3 cells, demonstrating a strong STING activation effect, but it does not induce luciferase activity in THF-ISRE STING-/- cells, where activity was completely lost, and it maintains a dose-dependent increase in THF-ISRE TRIF/MAVS-/- cells[1].
STING agonist-48 does not cause any change in the thermal stability of the STING cytoplasmic domain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STING agonist-48 Related Antibodies
In Vivo

STING agonist-48 (Compound 7k) (20 μg, i.m., once on day 0 and day 14) as a vaccine adjuvant can significantly enhance Th1/Th2-mediated antigen-specific humoral and cellular immune responses in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female C57BL/6 humanized STING (huSTING; 6-12 weeks) mice were intramuscularly immunized and boosted (at a two-week interval) with 50 μL of either detergent-split A/Victoria/210/2009 (H3N2, A/Vic)[1].
Dosage: 20 μg
Administration: I.m., 0 day, 14 days
Result: Serum IgG1, IgG2, and total IgG titers were significantly increased in mice.
Increased secretion of IFN-γ, IL-4, and IL-5 from spleen cells.
Molecular Weight

476.44

Formula

C23H16F4N2O3S
CAS No.
SMILES

O=C(C1=CC=C(N2CC3=C(O)C=CC=C3F)C(SCC2=O)=C1)NCC4=C(F)C=C(F)C=C4F
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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STING agonist-48 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING agonist-483027712-31-5STING agonist48STING agonist 48STINGStimulator of Interferon GenesTMEM173MITAERISMPYSCytosolic cyclic dinucleotideCDNImmunotherapyInnate immuneSTING agonistsStimulator of interferon genesTransmembrane domainTMDInhibitorinhibitorinhibit

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