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Results for "

rat liver microsomal

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (2) Biochemical Assay Reagents (2) CD38 (1) Farnesyl Transferase (3) Fungal (2) Isotope-Labeled Compounds (1) Reactive Oxygen Species (ROS) (2) Stearoyl-CoA Desaturase (SCD) (1)
By Research Areas:	Cardiovascular Disease (6) Infection (2) Inflammation/Immunology (3) Metabolic Disease (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Microsomal Triglyceride Transfer Protein (MTP) LXR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107410

SC-26196 3 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Inflammation/Immunology
SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC₅₀=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties .

HY-N4193

Glabrol 3 Publications Verification	Acyltransferase	Cardiovascular Disease
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ value of 24.6 μM for rat liver microsomal ACAT activity .

HY-150508

MK-0159	CD38	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
MK-0159 is an orally active, potent and selective CD38 inhibitor, with IC₅₀ values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD ⁺ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart .

HY-100299A

RPR107393	Farnesyl Transferase	Cardiovascular Disease Metabolic Disease
RPR107393 is an orally active potent selective squalene synthase (SQS) inhibitor. RPR107393 inhibits rat liver microsomal squalene synthase with an IC₅₀ value of 0.8 nM. RPR107393 reduces triglyceride biosynthesis by suppressing fatty acid biosynthesis via an increase in intracellular farnesol and its derivatives. RPR107393 reduces plasma cholesterol in rats and marmosets. RPR107393 can be used for metabolic disease research, such as hypercholesterolemia, hypertriglyceridemia and atherosclerosis ^[1][2].

HY-100299

RPR107393 free base	Farnesyl Transferase	Cardiovascular Disease Metabolic Disease
RPR107393 free base is an orally active potent selective squalene synthase (SQS) inhibitor. RPR107393 free base inhibits rat liver microsomal squalene synthase with an IC₅₀ value of 0.8 nM. RPR107393 free base reduces triglyceride biosynthesis by suppressing fatty acid biosynthesis via an increase in intracellular farnesol and its derivatives. RPR107393 free base reduces plasma cholesterol in rats and marmosets. RPR107393 free base can be used for metabolic disease research, such as hypercholesterolemia, hypertriglyceridemia and atherosclerosis ^[1][2].

HY-16197

Epicochlioquinone A	Acyltransferase	Inflammation/Immunology
Epicochlioquinone A can inhibit rat liver microsomal ACAT with IC₅₀ of 1.7 μM, inhibit plasma lecithin cholesterol acyltransferase (LCAT) with IC₅₀ of 15.8 μM, and inhibit cholesterol absorption in rats by 50% at 75 mg/kg .

HY-113587

Nicoclonate hydrochloride Nicoclonol hydrochloride	Others	Others
Nicoclonate (hydrochloride)(Nicoclonol (hydrochloride)) is an antilipemic agent .

HY-177148

G256	Biochemical Assay Reagents	Cardiovascular Disease
G256 (Compound 1) is an amidinohydrazone. G256 can also be considered as a Schiff’s base of aminoguanidine. G256 exhibits antiarrhythmic activity. G256 is the reduced form of NOH-G256 by microsomal enzyme preparation from rabbit and rat liver homogenates in the presence of NADPH and NADH .

HY-177148A

G256 dihydrochloride	Biochemical Assay Reagents	Cardiovascular Disease
G256 (Compound 1) (dihydrochloride) is an amidinohydrazone. G256 (dihydrochloride) can also be considered as a Schiff’s base of aminoguanidine. G256 (dihydrochloride) exhibits antiarrhythmic activity. G256 (dihydrochloride) is the reduced form of NOH-G256 by microsomal enzyme preparation from rabbit and rat liver homogenates in the presence of NADPH and NADH .

HY-B2097

Incadronate disodium YM 175; Bisphonal	Farnesyl Transferase	Metabolic Disease
Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (K_i=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC₅₀=64 μM). Incadronate disodium has the potential for malignant tumors research .

HY-B0847S1

Propiconazole-d3 nitrate	Fungal Reactive Oxygen Species (ROS)	Infection
Propiconazole-d₃ (nitrate) is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).

HY-B0847S

Propiconazole-d7	Isotope-Labeled Compounds Fungal Reactive Oxygen Species (ROS)	Infection
Propiconazole-d₇ is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC₅₀s=0.04 and >200 μM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 μg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4193

Glabrol 3 Publications Verification	Cardiovascular Disease Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields	Acyltransferase
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ value of 24.6 μM for rat liver microsomal ACAT activity .

HY-16197

Epicochlioquinone A	Natural Products Microorganisms Source classification	Acyltransferase
Epicochlioquinone A can inhibit rat liver microsomal ACAT with IC₅₀ of 1.7 μM, inhibit plasma lecithin cholesterol acyltransferase (LCAT) with IC₅₀ of 15.8 μM, and inhibit cholesterol absorption in rats by 50% at 75 mg/kg .

Cat. No.	Product Name	Chemical Structure

HY-B0847S1

Propiconazole-d3 nitrate
Propiconazole-d₃ (nitrate) is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).

Propiconazole-d3 nitrate

Propiconazole-d₃ (nitrate) is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).

HY-B0847S

Propiconazole-d7
Propiconazole-d₇ is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC₅₀s=0.04 and >200 μM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 μg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS) .

Propiconazole-d7

Propiconazole-d₇ is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC₅₀s=0.04 and >200 μM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 μg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS) .

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