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Results for "

loops

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) ADC Linker (2) ADC Payload (1) Adenosine Deaminase (1) Akt (2) Aldose Reductase (1) Amyloid-β (2) Angiotensin Receptor (1) Antibiotic (2) Apoptosis (7) Autophagy (2) Bacterial (4) Bcl-2 Family (1) Bcr-Abl (1) Biochemical Assay Reagents (5) c-Kit (4) CCR (1) CDK (1) Chloride Channel (1) Cholinesterase (ChE) (1) Cyclic GMP-AMP Synthase (2) Dengue Virus (1) DNA Methyltransferase (2) DNA/RNA Synthesis (4) Endogenous Metabolite (6) Epigenetic Reader Domain (1) ERK (3) Fungal (2) G-quadruplex (1) GABA Receptor (5) Gap Junction Protein (6) HIV (7) IFNAR (3) iGluR (2) IKK (2) Insecticide (1) Integrin (4) Interleukin Related (1) Isotope-Labeled Compounds (2) JAK (1) Lipocalin Family (1) MDM-2/p53 (1) MEK (3) mRNA (8) MyD88 (1) NF-κB (1) NKCC (12) Opioid Receptor (2) PDGFR (3) Phosphatase (1) PI3K (3) PKC (2) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (2) PPAR (2) PROTACs (1) Protein Arginine Deiminase (1) Proton Pump (3) RAD51 (2) Reactive Oxygen Species (ROS) (2) Reference Standards (8) Sirtuin (2) Sodium Channel (2) STAT (2) Telomerase (3) TNF Receptor (4) Toll-like Receptor (TLR) (2) VEGFR (1) WNK Kinase (1) Wnt (2) β-catenin (1) β-glucuronidase (1)
By Research Areas:	Cancer (38) Cardiovascular Disease (21) Endocrinology (1) Infection (15) Inflammation/Immunology (12) Metabolic Disease (20) Neurological Disease (12)
Oligonucleotides:	Nucleoside Analogs (1) Uridine (1) mRNA (8)

108

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107321

Azosemide 3 Publications Verification	NKCC	Metabolic Disease
Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC₅₀s of 0.246 μM and 0.197 μM for hNKCC1A and NKCC1B, respectively .

HY-106616

Muzolimine BAY-g 2821; Edrul	Sodium Channel	Cardiovascular Disease
Muzolimine (BAY-g 282) is a slow and long lasting diuresis agent. Muzolimine produces a diuresis in the loop of Henle and also shows anti-hypertensive and natriuresis effects. Muzolimine can be used for the research of cardiovascular disease .

HY-P5228A

KSDSC TFA	Biochemical Assay Reagents	Others
KSDSC TFA is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, KSDSC TFA joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi) .

HY-N2587

Irigenin	Integrin Apoptosis	Cancer
Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells .

HY-P1136

Gap19 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .

HY-107321R

Azosemide (Standard)	NKCC	Metabolic Disease
Azosemide (Standard) is the analytical standard of Azosemide. This product is intended for research and analytical applications. Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC50s of 0.246 μM and 0.197 μM for hNKCC1A and NKCC1B, respectively .

HY-B2081A

Etozolin hydrochloride W-2900A hydrochloride	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Etozolin hydrochloride is a diuretic agent. Etozolin hydrochloride inhibits fluid and electrolyte reabsorption in the loop of Henle. Etozolin hydrochloride can be used in research of congestive heart failure, hypertension and edema .

HY-106616R

Muzolimine (Standard) BAY-g 2821 (Standard); Edrul (Standard)	Sodium Channel Reference Standards	Cardiovascular Disease
Muzolimine (Standard) is the analytical standard of Muzolimine. This product is intended for research and analytical applications. Muzolimine (BAY-g 282) is a slow and long lasting diuresis agent. Muzolimine produces a diuresis in the loop of Henle and also shows anti-hypertensive and natriuresis effects. Muzolimine can be used for the research of cardiovascular disease .

HY-B2081

Etozolin W-2900A	Others	Cardiovascular Disease Metabolic Disease
Etozolin (W-2900A) is a diuretic agent. Etozolin inhibits fluid and electrolyte reabsorption in the loop of Henle. Etozolin can be used in research of congestive heart failure, hypertension and edema .

HY-P5228

KSDSC	Biochemical Assay Reagents	Others
KSDSC is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, KSDSC joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi) .

HY-P1136A

Gap19 TFA 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .

HY-N2587R

Irigenin (Standard)	Reference Standards Integrin Apoptosis	Cancer
Irigenin (Standard) is the analytical standard of Irigenin. This product is intended for research and analytical applications. Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells .

HY-P10550

VGB4	VEGFR	Cancer
VGB4 is a VEGF-A and VEGF-B antagonist peptide that duplicates two binding domains of VEGF-B (loop 1 and loop3) and are linked together by the receptor-binding domain of VEGF-A (loop3). VGB4 has significant anti-angiogenic and anti-tumor activities and can regulate tumor growth and metastasis through multiple mechanisms. VGB4 could be used in anti-tumor research .

HY-113047

5,6-Dihydrouridine 2 Publications Verification	Endogenous Metabolite	Others
5,6-Dihydrouridine is a modified base found in conserved positions in the D-loop of tRNA in Bacteria, Eukaryota, and some Archaea.

HY-119177

PD173956	Bcr-Abl	Others
PD173956 is a pyridopyrimidine Bcr-Abl kinase inhibitor with high selectivity for the P-loop mutant form of Bcr-Abl .

HY-174570

Human NEUROG3 mRNA	mRNA	Neurological Disease
Human NEUROG3 mRNA encodes the human neurogenin 3 (NEUROG3) protein, a basic helix-loop-helix (bHLH) transcription factor that involved in neurogenesis.

HY-163513

AACA	Wnt	Endocrinology
AACA is an inhibitor for sclerostin, that binds sclerostin on loop3 region with K_d of 15.4 nM. AACA exhibits anti-osteoporosis activity through Wnt signaling pathway .

HY-126179

Fenquizone MG-13054	Potassium Channel	Cardiovascular Disease Metabolic Disease
Fenquizone (MG-13054) is an orally active diuretic. Fenquizone acts primarily on the diluting segment of the nephron cortex, similar to thiazide diuretics. Fenquizone demonstrates diuretic and natriuretic potency and duration of action comparable to thiazide diuretics but weaker than loop diuretics. Fenquizone reduces CH₂O without affecting TCH₂O, does not increase calcium/phosphate excretion, and has no loop or collecting duct effects. Fenquizone is used in the study of edema and hypertension .

HY-P1082

Gap 26 5+ Cited Publications	Gap Junction Protein	Cardiovascular Disease
Gap 26 is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .

HY-W009444

5-Methyluridine 1 Publications Verification	Endogenous Metabolite	Others
5-Methyluridine (m ⁵U) is an RNA modified nucleotide generated by RNA methyltransferases (such as TrmA and RumA), which mainly targets specific uracil sites in RNA molecules such as the T arm of tRNA and rRNA. 5-Methyluridine relies on enzyme recognition of RNA secondary/tertiary structures (such as the T loop of tRNA or the specific stem-loop structure of rRNA) and participates in physiological processes such as translation accuracy and ribosome function by stabilizing RNA folding or regulating base pairing .

HY-P1082A

Gap 26 TFA 5+ Cited Publications	Gap Junction Protein	Cardiovascular Disease
Gap 26 TFA is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .

HY-129359

PDP-Pfp	ADC Linker	Cancer
PDP-Pfp is a reducible ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) .

HY-B0247

Torsemide 1 Publications Verification Torasemide	NKCC	Cardiovascular Disease Metabolic Disease
Torsemide (Torasemide) is an orally active loop diuretic. Torsemide has anti-aldosterone and vasodilatory effects. Torsemide also can be used for the research of heart failure, renal disease and hepatic cirrhosis .

HY-P1594

Dynorphin A (1-10)	Opioid Receptor iGluR	Neurological Disease
Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC₅₀ of 42.0 μM.

HY-P0139

Gap 27 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment .

HY-18849

ERK2-IN-3	ERK	Cancer
ERK2-IN-3 (compound 2) is a inhibitor of ERK2, and inhibits Erk2 ^WT and Erk2 ^DS1 activation loop phosphorylation, with IC₅₀ of 5 μM and 42 nM, respectively .

HY-126179R

Fenquizone (Standard)	Reference Standards Potassium Channel	Cardiovascular Disease Metabolic Disease
Fenquizone (MG-13054) (Standard) is the analytical standard of Fenquizone (HY-126179). This product is intended for research and analytical applications. Fenquizone is an orally active diuretic. Fenquizone acts primarily on the diluting segment of the nephron cortex, similar to thiazide diuretics. Fenquizone demonstrates diuretic and natriuretic potency and duration of action comparable to thiazide diuretics but weaker than loop diuretics. Fenquizone reduces CH₂O without affecting TCH₂O, does not increase calcium/phosphate excretion, and has no loop or collecting duct effects. Fenquizone is used in the study of edema and hypertension.

HY-P1594A

Dynorphin A (1-10) (TFA)	Opioid Receptor iGluR	Neurological Disease
Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC₅₀ of 42.0 μM.

HY-W111168

Acid chrome blue K	Biochemical Assay Reagents	Others
Acid chrome blue K is a metal indicator. The solution color of the LAMP (Loop-mediated isothermal amplification) reaction with ACBK (Acid chrome blue K) changes from red to blue based on a decrease in the Mg ²⁺ concentration in the reaction solution .

HY-P99102

Zinlirvimab 10-1074	HIV	Infection
Zinlirvimab is a human IgG1-λ2, HIV neutralising antibody targeting to HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop) .

HY-174571

Human NEUROG2 mRNA	mRNA	Neurological Disease
Human NEUROG2 mRNA encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells. NEUROG2 plays a role in the differentiation and survival of midbrain dopaminergic neurons.

HY-W011400

TLR1 3 Publications Verification	MyD88	Inflammation/Immunology
TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses .

HY-129372

PDdB-Pfp	ADC Linker	Cancer
PDdB-Pfp is a cleavable ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) .

HY-113047R

5,6-Dihydrouridine (Standard)	Endogenous Metabolite	Others
5,6-Dihydrouridine (Standard) is the analytical standard of 5,6-Dihydrouridine. This product is intended for research and analytical applications. 5,6-Dihydrouridine is a modified base found in conserved positions in the D-loop of tRNA in Bacteria, Eukaryota, and some Archaea.

HY-122177

MK181	Aldose Reductase	Cancer
MK181 is an aldose reductase (AR) inhibitor with IC₅₀s of 0.71 μM and 4.5 μM for aldose reductase and AKR1B10, respectively. MK181 can bind into the external loop A subpocket of AKR1B10 .

HY-156659

NC1	Phosphatase	Others
NC1 is a noncompetitive and allosteric lymphoid-specific tyrosine phosphatase (LYP) inhibitor, with a K_i value 4.3 μM. NC1 inhibits LYP by restricting the movement of the WPD-loop. NC1 inhibits LYP-mediated TCR signaling in T cells .

HY-B0247S

Torsemide-d7 Torasemide-d₇	Isotope-Labeled Compounds	Cardiovascular Disease Metabolic Disease
Torsemide-d₇ is the deuterium labeled Torsemide. Torsemide (Torasemide) is an orally active loop diuretic. Torsemide has anti-aldosterone and vasodilatory effects. Torsemide also can be used for the research of heart failure, renal disease and hepatic cirrhosis .

HY-E70807

Biotin-WNK3 Recombinant Human Active Protein Kinase	WNK Kinase	Neurological Disease
WNK3 is a WNK kinase that associates with and activate SPAK/OSR1 by phosphorylation of its T-loop at Thr233 and Thr185. Biotin-WNK3 Recombinant Human Active Protein Kinase is obtained by expressing WNK3 proteins and is biotinylated .

HY-174778

Human ASCL1 mRNA	mRNA	Neurological Disease
Human ASCL1 mRNA encodes the human achaete-scute family bHLH transcription factor 1 (ASCL1) protein, a member of the basic helix-loop-helix (BHLH) family. ASCL1 plays a role in the neuronal commitment and differentiation, and in the generation of olfactory and autonomic neurons.

HY-W331198

Tralopyril	Insecticide	Infection
Tralopyril is an insecticide that has significant insecticidal activity against pests like the tobacco budworm, two-spotted spider mite, and potato leafhopper, but it is highly toxic to plants .

HY-17468A

Bumetanide sodium Ro 10-6338 sodium; PF 1593 sodium	NKCC	Cardiovascular Disease Metabolic Disease
Bumetanide sodium, a highly potent loop diuretic, is a Na ⁺-K ⁺-Cl ⁺ cotransporter (NKCC) blocker. Bumetanide sodium is a selective NKCC1 inhibitor, and also inhibits NKCC2, with IC₅₀s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively .

HY-P10829

MLH40	Dengue Virus	Infection
MLH40 is a peptide inhibitor with activity against Dengue virus (DENV) infection, which is found in the conserved ectodomain region of DENV membrane protein. MLH40 inhibits DENV through its N-terminal loop interaction with DENV envelope protein and altering the dimer conformation .

HY-169173

AL284	Cholinesterase (ChE)	Infection
AL284 is a potent anopheles gambiae acetylcholinesterase 1 (AgAChE1) inhibitor. AL284 interactions with Tyr489Ag in the α-helix next to loop 2, and Trp441Ag at the top of the gorge. AL284 has the potential for the research of disease-transmitting mosquitoes .

HY-P1508

Bactenecin Bactenecin, bovine	Bacterial Fungal Antibiotic	Infection
Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-B0247R

Torsemide (Standard) 1 Publications Verification Torasemide (Standard)	NKCC Reference Standards	Cardiovascular Disease Metabolic Disease
Torsemide (Standard) is the analytical standard of Torsemide. This product is intended for research and analytical applications. Torsemide (Torasemide) is an orally active loop diuretic. Torsemide has anti-aldosterone and vasodilatory effects. Torsemide also can be used for the research of heart failure, renal disease and hepatic cirrhosis .

HY-163035

EM-163	TNF Receptor IFNAR	Inflammation/Immunology
EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B) .

HY-174580

Human MITF mRNA	mRNA	Cancer
Human MITF mRNA encodes the human melanocyte inducing transcription factor (MITF) protein, a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. MITF could regulate melanocyte development and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes.

HY-148200A

L2H2-6OTD diformic	Telomerase	Cancer
L2H2-6OTD acetate contains one to four G-quadruplex binding loops and is a telomere inhibitor analog. L2H2-6OTD acetate has telomerase inhibitory activity with an IC₅₀ value of 15 nM .

HY-161693

Telomeric G4s ligand 1	G-quadruplex DNA/RNA Synthesis Apoptosis	Cancer
Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, leading to DNA damage responses. Telomeric G4s ligand 1 induces apoptosis and evokes immunogenic cell death (ICD) in tumor cells .

HY-175419

TBIA trans bis-Isatoic anhydride	DNA/RNA Synthesis	Cancer
TBIA (trans bis-isatoic anhydride) is a covalent RNA crosslinker. TBIA selectively induces RNA tertiary interactions (e.g., multi-helix junctions, loop-helix packing). TBIA is promising for research of RNA higher-order structure and disease-associated RNAs (e.g., KRAS-mutant RNAs) .

Cat. No.	Product Name

HY-L0119V

Asinex PPI Pre-Plated Library

3,253 compounds

Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases. However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures.

The PPI Library comprises molecules of various sizes, frameworks, and shapes ranging from fragment-like entities to macrocyclic derivatives designed as secondary structure mimetics or as epitope mimetics. The designs cover β-turn / loop mimetics and α-helix mimetics. Since helices present at the interface in 62% of all protein-protein interactions. This library focused on designs including mimics with the substitution geometry of an a-helices, as well as designs that mimic the location of “hot-spot” side chains in helix-mediated PPIs.

HY-L047

Endocrinology Compound Library

1,049 compounds

The endocrine system is a chemical messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. Hormones are chemicals that serve to communicate between organs and tissues for physiological regulation and behavioral activities. Hormones affect distant cells by binding to specific receptor proteins in the target cell, resulting in a change in cell function.

The endocrine system is concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Irregulated hormone release, inappropriate response to signaling or lack of a gland can lead to endocrine disease.

MCE offers a unique collection of 1,049 endocrinology related compounds targeting varieties of hormone receptors such as thyroid hormone receptor, TSH receptor, GNRH receptor, adrenergic receptor, etc. MCE Endocrinology Compound Library is a useful tool for the discovery of endocrinology drugs.

Cat. No.	Product Name	Type

HY-W111168

Acid chrome blue K	Indicators
Acid chrome blue K is a metal indicator. The solution color of the LAMP (Loop-mediated isothermal amplification) reaction with ACBK (Acid chrome blue K) changes from red to blue based on a decrease in the Mg ²⁺ concentration in the reaction solution .

HY-W110910

Eriochrome black T, Indicator

Indicators

Eriochrome black T, Indicator is a complexing agent for metal ions (e.g., Ca ²⁺, Mg ²⁺) and is used as an indicator in complexometric titrations. Eriochrome black T, Indicator forms colored complexes with metal ions through covalent coordination bonds, and indicates the endpoint of the titration by color change. Eriochrome black T, Indicator can be used as an anionic azo dye in photocatalytic degradation studies to evaluate the performance of photocatalysts. The reaction solution of Eriochrome black T, Indicator combined with Mg ²⁺ is initially purple. During loop-mediated isothermal amplification (LAMP), the color changes from purple to sky blue due to the consumption of Mg ²⁺ by the formation of magnesium pyrophosphate, indicating a positive reaction. The optimal concentration of Eriochrome black T, Indicator in LAMP is 60 μM, and the detection limit for Mycobacterium tuberculosis is 1 pg DNA/reaction .

HY-NP008

β-Lactoglobulin

Native Proteins

β-Lactoglobulin, a major whey protein, is a small globular protein from the lipocalin family. β-Lactoglobulin is an important source of the essential and branched-chain amino acids (leucine, isoleucine, and valine). β-Lactoglobulin shows antioxidant properties, because it contains two disulfide bonds and one free thiol group. β-Lactoglobulin is a ligand transport agent. β-Lactoglobulin is one of the major allergens in milk and can be utilized in the research for developing safe hypoallergenic dairy products .

Cat. No.	Product Name	Target	Research Area

HY-P5229A

IHRIC TFA	Peptides	Others
IHRIC TFA is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, IHRIC TFA joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi) .

HY-P5228A

KSDSC TFA	Biochemical Assay Reagents	Others
KSDSC TFA is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, KSDSC TFA joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi) .

HY-P1136

Gap19 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .

HY-P1136A

Gap19 TFA 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .

HY-P1598

GroES mobile loop	Peptides	Others
GroES mobile loop is a highly flexible region of free GroES, which binds to GroEL through the residues at the tip of the loop.

HY-P1082

Gap 26 Maximum Cited Publications 8 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap 26 is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .

HY-P1082A

Gap 26 TFA Maximum Cited Publications 8 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap 26 TFA is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .

HY-P5229

IHRIC	Peptides	Others
IHRIC is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, IHRIC joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi) .

HY-P5228

KSDSC	Biochemical Assay Reagents	Others
KSDSC is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, KSDSC joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi) .

HY-P10550

VGB4	VEGFR	Cancer
VGB4 is a VEGF-A and VEGF-B antagonist peptide that duplicates two binding domains of VEGF-B (loop 1 and loop3) and are linked together by the receptor-binding domain of VEGF-A (loop3). VGB4 has significant anti-angiogenic and anti-tumor activities and can regulate tumor growth and metastasis through multiple mechanisms. VGB4 could be used in anti-tumor research .

HY-P1594

Dynorphin A (1-10)	Opioid Receptor iGluR	Neurological Disease
Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC₅₀ of 42.0 μM.

HY-P0139

Gap 27 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment .

HY-P1594A

Dynorphin A (1-10) (TFA)	Opioid Receptor iGluR	Neurological Disease
Dynorphin A (1-10) (TFA), an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) (TFA) also blocks NMDA-activated current with an IC₅₀ of 42.0 μM.

HY-P10829

MLH40	Dengue Virus	Infection
MLH40 is a peptide inhibitor with activity against Dengue virus (DENV) infection, which is found in the conserved ectodomain region of DENV membrane protein. MLH40 inhibits DENV through its N-terminal loop interaction with DENV envelope protein and altering the dimer conformation .

HY-P1508

Bactenecin Bactenecin, bovine	Bacterial Fungal Antibiotic	Infection
Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-P1508A

Bactenecin TFA Bactenecin, bovine TFA	Bacterial Fungal	Infection
Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-P10597

Angiotensin II type 1 receptor (181-187)	Angiotensin Receptor	Others
Angiotensin II type 1 receptor (181-187) is a 9-amino acid sequence of the second extracellular loop of angiotensin II (Ang II) in the renin-angiotensin system. Angiotensin II type 1 receptor (181-187) serves as the localization epitope of angiotensin II receptor autoantibodies (AT1RaAb) and is used to detect and quantify AT1RaAb levels in serum .

HY-P2612A

WP9QY TFA	TNF Receptor	Others Cancer
WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. (This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.)

HY-P2612

WP9QY	TNF Receptor	Others
WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. (This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.)

HY-P10817

Corza6	Proton Pump Reactive Oxygen Species (ROS)	Metabolic Disease
Corza6 is a potent and selective human voltage-gated proton channel (hHv1) peptide inhibitor. Corza6 binds to the external voltage sensor domain (VSD) loop in hHv1 with a K_d of ~1 nM at the natural, hyperpolarized resting membrane potential (RMP) of mammalian cells. Corza6 allows capacitation in sperm and permits sustained reactive oxygen species (ROS) production in white blood cells (WBCs) .

HY-P5389

Connexin mimetic peptide 40GAP27	Gap Junction Protein	Others
Connexin mimetic peptide 40GAP27 is a biological active peptide. (This peptide corresponds to the GAP27 domain of the second extracellular loop of dominant vascular connexin (Cx40), designated as 40Gap 27. It was used to investigate mechanisms through which oxidant stress impairs communication via gap junctions. When administered, 40Gap27attenuates endothelium-dependent subintimal smooth muscle hyperpolarization.)

HY-P10817A

Corza6 TFA	Proton Pump Reactive Oxygen Species (ROS)	Metabolic Disease
Corza6 TFA is a potent and selective human voltage-gated proton channel (hHv1) peptide inhibitor. Corza6 TFA binds to the external voltage sensor domain (VSD) loop in hHv1 with a K_d of ~1 nM at the natural, hyperpolarized resting membrane potential (RMP) of mammalian cells. Corza6 TFA allows capacitation in sperm and permits sustained reactive oxygen species (ROS) production in white blood cells (WBCs) .

HY-P5387

Connexin mimetic peptide 40,37GAP26	Peptides	Others
Connexin mimetic peptide 40,37GAP26 is a biological active peptide. (This peptide corresponds to the GAP26 domain of the extracellular loop of the major vascular connexins (Cx37, Cx40), designated as 37, 40Gap 26 according to Cx homology. It was used to investigate the role of gap junctions in the spread of endothelial hyperpolarizations evoked by cyclopiazonic acid (CPA) through the wall of the rodent iliac artery. The gap junction plaques constructed from Cx37 and Cx40 were abundant in the endothelium. This peptide provides inhibitory effects against subintimal hyperpolarization.)

HY-P10373

pJAK2(1001-1013)	JAK IFNAR Interleukin Related	Infection Inflammation/Immunology
pJAK2(1001-1013) is a cell-penetrating peptide that corresponds to the activation loop of JAK2 tyrosine kinase and functions as a SOCS1/3antagonist. pJAK2 (1001-1013) blocks SOCS1-mediated negative regulation of immune function, and enhances the biological activity of cytokines such as IFNγ and IL6. pJAK2(1001-1013) inhibits the replication of a broad range of viruses and exerts dose-dependent protective efficacy against lethal viral infections. pJAK2(1001-1013) can be used for the study of immune regulation and infection .

Cat. No.	Product Name

HY-K0513

RT Master Mix for qPCR III 1 Publications Verification
MCE MCE Reverse Transcription Kit III is suitable for the conventional synthesis of cDNA from RNA and the stem-loop method for the synthesis of cDNA from microRNA (miRNA).

Cat. No.	Product Name	Target	Research Area

HY-P99102

Zinlirvimab 10-1074	HIV	Infection
Zinlirvimab is a human IgG1-λ2, HIV neutralising antibody targeting to HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop) .

HY-P991541

HGS101	CCR HIV	Infection
HGS101 is a fully human CCR5 monoclonal antibody with high affinity to CCR5. HGS101 binds to the 2nd extracellular loop (ECL-2) and acts as a signal antagonist. HGS101 restores Maraviroc (HY-13004) inhibition of Maraviroc-resistant HIV-1 infection of PBMCs. HGS101 shows anti-HIV activity by inhibiting CCR5 signaling in simian immunodeficiency virus-uninfected RMs models .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2587

Irigenin	Flavonoids Iridaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Isoflavones Cancer	Integrin Apoptosis
Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells .

HY-113047

5,6-Dihydrouridine 2 Publications Verification	Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
5,6-Dihydrouridine is a modified base found in conserved positions in the D-loop of tRNA in Bacteria, Eukaryota, and some Archaea.

HY-W009444

5-Methyluridine 1 Publications Verification	Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Methyluridine (m ⁵U) is an RNA modified nucleotide generated by RNA methyltransferases (such as TrmA and RumA), which mainly targets specific uracil sites in RNA molecules such as the T arm of tRNA and rRNA. 5-Methyluridine relies on enzyme recognition of RNA secondary/tertiary structures (such as the T loop of tRNA or the specific stem-loop structure of rRNA) and participates in physiological processes such as translation accuracy and ribosome function by stabilizing RNA folding or regulating base pairing .

HY-P1508A

Bactenecin TFA Bactenecin, bovine TFA	Infection Natural Products Classification of Application Fields Animals Source classification Disease Research Fields	Bacterial Fungal
Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-W012078

5-Methyl-2'-deoxycytidine 3 Publications Verification 5-Methyldeoxycytidine	Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	DNA Methyltransferase Endogenous Metabolite
5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .

HY-N2587R

Irigenin (Standard)	Flavonoids Iridaceae Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Isoflavones	Reference Standards Integrin Apoptosis
Irigenin (Standard) is the analytical standard of Irigenin. This product is intended for research and analytical applications. Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells .

HY-113047R

5,6-Dihydrouridine (Standard)	Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
5,6-Dihydrouridine (Standard) is the analytical standard of 5,6-Dihydrouridine. This product is intended for research and analytical applications. 5,6-Dihydrouridine is a modified base found in conserved positions in the D-loop of tRNA in Bacteria, Eukaryota, and some Archaea.

HY-P1508

Bactenecin Bactenecin, bovine	Infection Animals Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Fungal Antibiotic
Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-N10768

1-Dehydro-[10]-gingerdione	Monophenols Source classification Phenols Plants Zingiberaceae	IKK NF-κB
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

HY-W012078R

5-Methyl-2'-deoxycytidine (Standard)	Natural Products Source classification Endogenous metabolite	DNA Methyltransferase Endogenous Metabolite
5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .

HY-N2110R

Phellopterin (Standard)	Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants	Reference Standards Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.

HY-N2110

Phellopterin	Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants Inflammation/Immunology Disease Research Fields	Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus .

Cat. No.	Product Name	Chemical Structure

HY-B0247S

Torsemide-d7
Torsemide-d₇ is the deuterium labeled Torsemide. Torsemide (Torasemide) is an orally active loop diuretic. Torsemide has anti-aldosterone and vasodilatory effects. Torsemide also can be used for the research of heart failure, renal disease and hepatic cirrhosis .

HY-B0135S

Furosemide-d5

Furosemide-d₅ is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl-?(NKCC) cotransporter, NKCC1 and NKCC2 .?Furosemide is also a GABAA?receptors antagonist and displays 100-fold selectivity for?α6-containing receptors than?α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .

HY-W754911

Avapritinib-d3

Avapritinib-d₃ (BLU-285-d₃) is deuterium labeled Avapritinib. Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC₅₀s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2 .

HY-B1588S

Carbenoxolone-d4

Carbenoxolone-d₄ is deuterium labeled Carbenoxolone. Carbenoxolone, a semi-synthetic derivative of glycyrrhetinic acid, has previously been used for the management of dyspepsia and peptic ulcer because of its anti-inflammatory properties . Carbenoxolone, a general hemichannel and gap junction inhibitor, has the therapeutic potential of carbenoxolone in the research of chronic liver disease . Carbenoxolone is a suitable candidate for the inhibition of Aβ42 aggregation and the therapeutic potential of Cbx against AD . Carbenoxolone is small molecule Pannexin1 (Panx1,is an ATP release channel) inhibitor, attenuate Panx1 channel activity through modulation of the first extracellular loop .Carbenoxolone is an 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor that converts inactive glucocorticoid into an active form. Carbenoxolone has antiviral activity against DENV infection targeting the virus itself .

Cat. No.	Product Name		Classification

HY-W009444

5-Methyluridine 1 Publications Verification		Nucleoside Analogs Uridine
5-Methyluridine (m ⁵U) is an RNA modified nucleotide generated by RNA methyltransferases (such as TrmA and RumA), which mainly targets specific uracil sites in RNA molecules such as the T arm of tRNA and rRNA. 5-Methyluridine relies on enzyme recognition of RNA secondary/tertiary structures (such as the T loop of tRNA or the specific stem-loop structure of rRNA) and participates in physiological processes such as translation accuracy and ribosome function by stabilizing RNA folding or regulating base pairing .

HY-174570

Human NEUROG3 mRNA		mRNA
Human NEUROG3 mRNA encodes the human neurogenin 3 (NEUROG3) protein, a basic helix-loop-helix (bHLH) transcription factor that involved in neurogenesis.

HY-174571

Human NEUROG2 mRNA		mRNA
Human NEUROG2 mRNA encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells. NEUROG2 plays a role in the differentiation and survival of midbrain dopaminergic neurons.

HY-174778

Human ASCL1 mRNA		mRNA
Human ASCL1 mRNA encodes the human achaete-scute family bHLH transcription factor 1 (ASCL1) protein, a member of the basic helix-loop-helix (BHLH) family. ASCL1 plays a role in the neuronal commitment and differentiation, and in the generation of olfactory and autonomic neurons.

HY-174580

Human MITF mRNA		mRNA
Human MITF mRNA encodes the human melanocyte inducing transcription factor (MITF) protein, a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. MITF could regulate melanocyte development and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes.

HY-174573

Human NEUROD1 mRNA		mRNA
Human NEUROD1 mRNA encodes the human neuronal differentiation 1 (NEUROD1)protein, a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. NEUROD1 forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box.

HY-174575

Human MYOD1 mRNA		mRNA
Human MYOD1 mRNA encodes the human myogenic differentiation 1 (MYOD1) protein, a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. MYOD1 acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.

HY-174572

Human NEUROD2 mRNA		mRNA
Human NEUROD2 mRNA encodes the human neuronal differentiation 2 (NEUROD2) protein, a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Human NEUROD2 can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.

HY-174536

Human TFE3 mRNA		mRNA
Human TFE3 mRNA encodes the human transcription factor binding to IGHM enhancer 3 (TFE3) protein, a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences. TFE3 may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins.

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