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Results for "

autophagy-related diseases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (2) Akt (1) Dopamine Transporter (1) PI3K (1) Serotonin Transporter (1) ULK (1)
By Research Areas:	Cancer (1) Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

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Targets Recommended: Autophagy Interleukin Related Atg4 Atg8/LC3 Oxysterol-binding Protein-related Protein (ORP) Mas-related G-protein-coupled Receptor (MRGPR) AUTOTACs AUTACs Mitophagy ER-phagy Trk Receptor ROR NEKs Kallikrein CGRP Receptor RUNX Arp2/3 Complex ATM/ATR sFRP-1 CD44 Neuropeptide S Receptor Cdc42-binding kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125199

ULK-100	ULK	Cancer
ULK-100 is a highly selective and potent ULK1 kinase inhibitor with an IC₅₀ value of 1.6 nM. ULK-100 is promising for research of autophagy-related diseases (e.g., KRAS-mutant lung cancer, glioblastoma) .

HY-158794

Lentztrehalose B	Autophagy	Neurological Disease
Lentztrehalose B is a dehydroxylated analog of trehalose A, possessing antioxidant properties that can be used in research on neurodegenerative diseases and other *autophagy*-related conditions .

HY-110019

Indatraline hydrochloride Lu 19-005	Serotonin Transporter Dopamine Transporter	Neurological Disease
Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces *autophagy* while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis .

HY-167843

Alborixin	Akt PI3K Autophagy	Neurological Disease
Alborixin is an inhibitor of the PI3K-AKT pathway that induces *autophagy. It promotes the clearance of intracellular and extracellular amyloid-β* by upregulating autophagy-related proteins (such as BECN1, ATG5, ATG7) and enhancing lysosomal activity, thereby reducing amyloid-β-mediated neurotoxicity. Alborixin shows potential for research in Alzheimer's disease .

Cat. No.	Product Name

HY-L029

Autophagy Compound Library	1,753 compounds
Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. MCE provides a unique collection of 1,753 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Autophagy Compound Library

1,753 compounds

Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease.

MCE provides a unique collection of 1,753 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-167843

Alborixin	Microorganisms Antibiotics Source classification	Akt PI3K Autophagy
Alborixin is an inhibitor of the PI3K-AKT pathway that induces *autophagy. It promotes the clearance of intracellular and extracellular amyloid-β* by upregulating autophagy-related proteins (such as BECN1, ATG5, ATG7) and enhancing lysosomal activity, thereby reducing amyloid-β-mediated neurotoxicity. Alborixin shows potential for research in Alzheimer's disease .

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