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Results for "

Suzuki coupling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (19) Drug Intermediate (6) G2A (GPR132) (1) Isotope-Labeled Compounds (2) Ras (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (1)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W019633

Benzothiazole-5-boronic acid pinacol ester	Biochemical Assay Reagents	Others
Benzothiazole-5-boronic acid pinacol ester is a compound that can be used in the boronate part of Suzuki coupling reactions .

HY-32928

4-Cyanobenzeneboronic acid	Biochemical Assay Reagents	Others
4-Cyanobenzeneboronic acid is a Boronic acid derivative. 4-Cyanobenzeneboronic acid can be used in Suzuki-Miyaura cross-coupling reactions .

HY-Y0747

Iodobenzene 1-Iodobenzene	Biochemical Assay Reagents	Others
Iodobenzene can undergo Ullmann coupling reaction on copper catalyst to generate biphenyl. Iodobenzene can undergo Suzuki reaction with phenylboronic acid to generate biphenyl .

HY-W001987

4,6-Dichloropyrimidin-5-amine	Biochemical Assay Reagents	Others
Organic ligands can be prepared through Suzuki cross-coupling reaction between 4,6-Dichloropyrimidin-5-amine and dimethyl(5-pinyl)isophthalate .

HY-W003601

2-Bromo-4-fluoropyridine	Biochemical Assay Reagents	Others
2-Bromo-4-fluoropyridine is a synthetic halogenated heterocyclic organic compound and a key intermediate in the pharmaceutical and agrochemical industries. 2-Bromo-4-fluoropyridine can be used to synthesize bioactive molecules through cross-coupling reactions, such as Suzuki coupling or Buchwald-Hartwig amination.

HY-W004698

(2-Methoxypyrimidin-5-yl)boronic acid	Drug Intermediate	Others
(2-Methoxypyrimidin-5-yl)boronic acid is a drug intermediate that can serve as a key reactant in the Suzuki-Miyaura coupling reaction, and is used for the synthesis of isoquinoline ketone derivatives with anti-tumor activity .

HY-Y0747S

Iodobenzene-d5 1-Iodobenzene-d₅	Isotope-Labeled Compounds	Others
Iodobenzene-d₅ is the deuterium labeled 1-Iodobenzene. Iodobenzene can undergo Ullmann coupling reaction on copper catalyst to generate biphenyl. Iodobenzene can undergo Suzuki reaction with phenylboronic acid to generate biphenyl .

HY-77642

4-(Methylsulfonyl)phenylboronic acid	Biochemical Assay Reagents Drug Intermediate	Metabolic Disease
4-(Methylsulfonyl)phenylboronic acid is an intermediate. 4-(Methylsulfonyl)phenylboronic acid can be used to synthesize GPR119 agonists via Suzuki coupling reaction. 4-(Methylsulfonyl)phenylboronic acid can be used in the research of type 2 diabetes .

HY-Y0747S1

Iodobenzene-d2 1-Iodobenzene-d₂	Isotope-Labeled Compounds	Others
Iodobenzene-d₂ is the deuterium labeled 1-Iodobenzene. Iodobenzene can undergo Ullmann coupling reaction on copper catalyst to generate biphenyl. Iodobenzene can undergo Suzuki reaction with phenylboronic acid to generate biphenyl .

HY-134811

KRAS G12D inhibitor 1	Ras	Cancer
KRAS G12D inhibitor 1 (Example 243) is a KRAS G12D inhibitor, with an IC₅₀ of 0.4 nM. KRAS G12D inhibitor 1 exhibits an IC₅₀ of 0.8 nM for KRAS G12D-mediated ERK phosphorylation. KRAS G12D inhibitor 1 can be used for the study of cancers with KRAS G12D mutations, such as pancreatic ductal adenocarcinoma and colorectal cancer .

HY-21623

Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct	Biochemical Assay Reagents	Others
Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct is a catalyst. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct stabilizes intermediates and reduces activation energy in coupling reactions. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct can be used in Suzuki-Miyaura coupling reactions .

HY-W002570

2-Naphthylboronic acid	Biochemical Assay Reagents	Others
2-Naphthylboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 2-Naphthylboronic acid can undergo silylation reaction. 2-Naphthylboronic acid also readily undergo Suzuki-Miyaura cross-coupling .

HY-W002801

2-Benzyloxyphenylboronic acid	Biochemical Assay Reagents	Others
2-Benzyloxyphenylboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 2-Benzyloxyphenylboronic acid is also a substrate used in asymmetric Suzuki coupling reactions. 2-Benzyloxyphenylboronic acid can be utilized in the synthesis of other active compounds .

HY-75637

3-Amino-5-methylpyrazole	Drug Intermediate	Others
5-Methyl-1H-pyrazol-3-amine is a pyrazole heterocyclic compound and can be used as a key intermediate for the synthesis of pyrazolylamide derivatives.

HY-32748

2-Bromo-5-fluoropyridine	Biochemical Assay Reagents Drug Intermediate	Others
2-Bromo-5-fluoropyridine is an intermediate. 2-Bromo-5-fluoropyridine can undergo Suzuki coupling reaction with Boronic acid (HY-41551). 2-Bromo-5-fluoropyridine can be used in the synthesis of GSK1292263A (a GPR119 receptor agonist) .

HY-W005558

6-Aminopyridine-3-boronic acid	Biochemical Assay Reagents	Others
6-Aminopyridine-3-boronic acid is a boronic acid derivative. Boronic acid derivatives are widely used in organic synthesis for carbon-carbon bond formation. In Suzuki coupling, aryl halides and boronic acid aryl or vinyl esters or boronic acid are coupled using Pd(PPh3)4. It can be used as a pharmaceutical intermediate ^{[1] ^.}

HY-75129

Pyridin-3-ylboronic acid	Biochemical Assay Reagents	Others
Pyridin-3-ylboronic acid is an organic compound. Pyridin-3-ylboronic acid is a key reagent in the Suzuki-Miyaura cross-coupling reaction. Pyridin-3-ylboronic acid is used in organic synthesis to construct oligopyridine compounds, and then as an α-helix mimetic to study protein-protein interactions .

HY-W003129

2-Bromo-4-chloropyridine	Biochemical Assay Reagents Drug Intermediate	Infection
2-Bromo-4-chloropyridine is an intermediate. 2-Bromo-4-chloropyridine undergoes Suzuki coupling reaction with 4-tert-butylphenylboronic acid (HY-W007389). 2-Bromo-4-chloropyridine facilitates the construction of compounds with broad-spectrum antibacterial activity .

HY-101974

Biotin-PEG3-Bromide	Biochemical Assay Reagents	Others
Biotin-PEG3-Bromide is a short PEG linker featuring a biotin group and a bromide. The bromide is a halogen which is easily displaced by nucleophiles such as alcohols or amines. Alternatively, bromide can be applied in a number of cross-coupling reactions such as in a Suzuki reaction. Biotin is useful for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins.

HY-32959

N-Boc-2-pyrroleboronic acid	Biochemical Assay Reagents	Others
N-Boc-2-pyrroleboronic acid is an organic synthesis intermediate used primarily in the synthesis of chiral pharmaceutical molecules and biologically active molecules. The boronic acid on the pyrrole ring can participate in Suzuki coupling reactions. The boronic acid can be oxidized to a hydroxyl group under the action of nitrogen oxides, and after tautomerization, it can be further transformed into 2-oxo-2,5-dihydro-1-pyrrolecarboxylic acid tert-butyl ester .

HY-114362

DL-alpha-Tocopherol methoxypolyethylene glycol succinate TPGS-750-M	Biochemical Assay Reagents	Others
DL-alpha-Tocopherol methoxypolyethylene glycol succinate (TPGS-750-M) is an amphiphile, acts as a surfactant. DL-alpha-Tocopherol methoxypolyethylene glycol succinate has a positive effect on Suzuki-Miyaura cross coupling. DL-alpha-Tocopherol methoxypolyethylene glycol succinate increases the styrene titer. DL-alpha-Tocopherol methoxypolyethylene glycol succinate is used in the stability test of NPYM-modified drugs in biological fluids .

HY-W002463

3-Chlorophenyl boronic acid	Biochemical Assay Reagents	Others
3-Chlorophenylboronic acid is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. 3-Chlorophenylboronic acid is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors among others. 3-Chlorophenyl boronic acid can affect cell migration. 3-Chlorophenyl boronic acid can be used to study wound healing .

HY-W020985

Bis[1,2-bis(diphenylphosphino)ethane]palladium(0) Pd(DIPHOS)2	Biochemical Assay Reagents	Others
Bis[1,2-bis(diphenylphosphino)ethane]palladium(0), often abbreviated as Pd(PPh3)2 or Pd(dppf), is an organometallic compound. This compound is widely used as a catalyst for organic chemical reactions, especially cross-coupling reactions such as Suzuki-Miyaura reaction and Heck reaction, and its high catalytic activity, selectivity and stability make it a versatile tool for the synthesis of complex organic compounds , in addition, the potential application of Pd(PPh3)2 in the production of electronic materials and in medical and biochemical research has also been investigated.

HY-171854

SB-583355	G2A (GPR132)	Neurological Disease Inflammation/Immunology
SB-583355 (Compound 56) is a potent G2A antagonist. SB-583355 can be prepared by a Suzuki reaction between 4-methoxyphenyl boronic acid and 3-bromo-4-hydroxybenzoic acid following the conditions followed by an amide coupling reaction. SB-583355 blocks the activation of G2A mediated either by 9-HOPE or T-10148 in human G2A expressing CHO-K1 cells. SB-583355 can be studied in research for inflammation, myeloid leukemia, and neuropathic pain .

HY-40190

5-Bromo-2,3-dihydro-1H-inden-1-one	Biochemical Assay Reagents Drug Intermediate	Metabolic Disease
5-Bromo-2,3-dihydro-1H-inden-1-one is a bromoindanone compound. 5-Bromo-2,3-dihydro-1H-inden-1-one acts as a key intermediate in organic synthesis, participating in reactions such as Suzuki coupling and Buchwald amination. 5-Bromo-2,3-dihydro-1H-inden-1-one can be used in the research of obesity-related metabolic diseases .

Cat. No.	Product Name	Type

HY-101974

Biotin-PEG3-Bromide	Fluorescent Dyes/Probes
Biotin-PEG3-Bromide is a short PEG linker featuring a biotin group and a bromide. The bromide is a halogen which is easily displaced by nucleophiles such as alcohols or amines. Alternatively, bromide can be applied in a number of cross-coupling reactions such as in a Suzuki reaction. Biotin is useful for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins.

Biotin-PEG3-Bromide

Fluorescent Dyes/Probes

Biotin-PEG3-Bromide is a short PEG linker featuring a biotin group and a bromide. The bromide is a halogen which is easily displaced by nucleophiles such as alcohols or amines. Alternatively, bromide can be applied in a number of cross-coupling reactions such as in a Suzuki reaction. Biotin is useful for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins.

Cat. No.	Product Name	Type

HY-32928

4-Cyanobenzeneboronic acid	Biochemical Assay Reagents
4-Cyanobenzeneboronic acid is a Boronic acid derivative. 4-Cyanobenzeneboronic acid can be used in Suzuki-Miyaura cross-coupling reactions .

HY-Y0747

Iodobenzene 1-Iodobenzene	Biochemical Assay Reagents
Iodobenzene can undergo Ullmann coupling reaction on copper catalyst to generate biphenyl. Iodobenzene can undergo Suzuki reaction with phenylboronic acid to generate biphenyl .

HY-W001987

4,6-Dichloropyrimidin-5-amine	Biochemical Assay Reagents
Organic ligands can be prepared through Suzuki cross-coupling reaction between 4,6-Dichloropyrimidin-5-amine and dimethyl(5-pinyl)isophthalate .

HY-W003601

2-Bromo-4-fluoropyridine	Biochemical Assay Reagents
2-Bromo-4-fluoropyridine is a synthetic halogenated heterocyclic organic compound and a key intermediate in the pharmaceutical and agrochemical industries. 2-Bromo-4-fluoropyridine can be used to synthesize bioactive molecules through cross-coupling reactions, such as Suzuki coupling or Buchwald-Hartwig amination.

HY-W004698

(2-Methoxypyrimidin-5-yl)boronic acid	Biochemical Assay Reagents
(2-Methoxypyrimidin-5-yl)boronic acid is a drug intermediate that can serve as a key reactant in the Suzuki-Miyaura coupling reaction, and is used for the synthesis of isoquinoline ketone derivatives with anti-tumor activity .

HY-77642

4-(Methylsulfonyl)phenylboronic acid	Biochemical Assay Reagents
4-(Methylsulfonyl)phenylboronic acid is an intermediate. 4-(Methylsulfonyl)phenylboronic acid can be used to synthesize GPR119 agonists via Suzuki coupling reaction. 4-(Methylsulfonyl)phenylboronic acid can be used in the research of type 2 diabetes .

HY-21623

Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct	Biochemical Assay Reagents
Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct is a catalyst. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct stabilizes intermediates and reduces activation energy in coupling reactions. Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct can be used in Suzuki-Miyaura coupling reactions .

HY-W002570

2-Naphthylboronic acid	Biochemical Assay Reagents
2-Naphthylboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 2-Naphthylboronic acid can undergo silylation reaction. 2-Naphthylboronic acid also readily undergo Suzuki-Miyaura cross-coupling .

HY-W002801

2-Benzyloxyphenylboronic acid	Biochemical Assay Reagents
2-Benzyloxyphenylboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 2-Benzyloxyphenylboronic acid is also a substrate used in asymmetric Suzuki coupling reactions. 2-Benzyloxyphenylboronic acid can be utilized in the synthesis of other active compounds .

HY-75637

3-Amino-5-methylpyrazole	Gene Sequencing and Synthesis
5-Methyl-1H-pyrazol-3-amine is a pyrazole heterocyclic compound and can be used as a key intermediate for the synthesis of pyrazolylamide derivatives.

HY-32748

2-Bromo-5-fluoropyridine	Biochemical Assay Reagents
2-Bromo-5-fluoropyridine is an intermediate. 2-Bromo-5-fluoropyridine can undergo Suzuki coupling reaction with Boronic acid (HY-41551). 2-Bromo-5-fluoropyridine can be used in the synthesis of GSK1292263A (a GPR119 receptor agonist) .

HY-75129

Pyridin-3-ylboronic acid	Biochemical Assay Reagents
Pyridin-3-ylboronic acid is an organic compound. Pyridin-3-ylboronic acid is a key reagent in the Suzuki-Miyaura cross-coupling reaction. Pyridin-3-ylboronic acid is used in organic synthesis to construct oligopyridine compounds, and then as an α-helix mimetic to study protein-protein interactions .

HY-W003129

2-Bromo-4-chloropyridine	Biochemical Assay Reagents
2-Bromo-4-chloropyridine is an intermediate. 2-Bromo-4-chloropyridine undergoes Suzuki coupling reaction with 4-tert-butylphenylboronic acid (HY-W007389). 2-Bromo-4-chloropyridine facilitates the construction of compounds with broad-spectrum antibacterial activity .

HY-32959

N-Boc-2-pyrroleboronic acid	Biochemical Assay Reagents
N-Boc-2-pyrroleboronic acid is an organic synthesis intermediate used primarily in the synthesis of chiral pharmaceutical molecules and biologically active molecules. The boronic acid on the pyrrole ring can participate in Suzuki coupling reactions. The boronic acid can be oxidized to a hydroxyl group under the action of nitrogen oxides, and after tautomerization, it can be further transformed into 2-oxo-2,5-dihydro-1-pyrrolecarboxylic acid tert-butyl ester .

N-Boc-2-pyrroleboronic acid

Biochemical Assay Reagents

N-Boc-2-pyrroleboronic acid is an organic synthesis intermediate used primarily in the synthesis of chiral pharmaceutical molecules and biologically active molecules. The boronic acid on the pyrrole ring can participate in Suzuki coupling reactions. The boronic acid can be oxidized to a hydroxyl group under the action of nitrogen oxides, and after tautomerization, it can be further transformed into 2-oxo-2,5-dihydro-1-pyrrolecarboxylic acid tert-butyl ester .

HY-W002463

3-Chlorophenyl boronic acid	Biochemical Assay Reagents
3-Chlorophenylboronic acid is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. 3-Chlorophenylboronic acid is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors among others. 3-Chlorophenyl boronic acid can affect cell migration. 3-Chlorophenyl boronic acid can be used to study wound healing .

3-Chlorophenyl boronic acid

Biochemical Assay Reagents

3-Chlorophenylboronic acid is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. 3-Chlorophenylboronic acid is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors among others. 3-Chlorophenyl boronic acid can affect cell migration. 3-Chlorophenyl boronic acid can be used to study wound healing .

HY-W020985

Bis[1,2-bis(diphenylphosphino)ethane]palladium(0) Pd(DIPHOS)2	Biochemical Assay Reagents
Bis[1,2-bis(diphenylphosphino)ethane]palladium(0), often abbreviated as Pd(PPh3)2 or Pd(dppf), is an organometallic compound. This compound is widely used as a catalyst for organic chemical reactions, especially cross-coupling reactions such as Suzuki-Miyaura reaction and Heck reaction, and its high catalytic activity, selectivity and stability make it a versatile tool for the synthesis of complex organic compounds , in addition, the potential application of Pd(PPh3)2 in the production of electronic materials and in medical and biochemical research has also been investigated.

Bis[1,2-bis(diphenylphosphino)ethane]palladium(0)

Pd(DIPHOS)2

Biochemical Assay Reagents

Bis[1,2-bis(diphenylphosphino)ethane]palladium(0), often abbreviated as Pd(PPh3)2 or Pd(dppf), is an organometallic compound. This compound is widely used as a catalyst for organic chemical reactions, especially cross-coupling reactions such as Suzuki-Miyaura reaction and Heck reaction, and its high catalytic activity, selectivity and stability make it a versatile tool for the synthesis of complex organic compounds , in addition, the potential application of Pd(PPh3)2 in the production of electronic materials and in medical and biochemical research has also been investigated.

HY-40190

5-Bromo-2,3-dihydro-1H-inden-1-one	Biochemical Assay Reagents
5-Bromo-2,3-dihydro-1H-inden-1-one is a bromoindanone compound. 5-Bromo-2,3-dihydro-1H-inden-1-one acts as a key intermediate in organic synthesis, participating in reactions such as Suzuki coupling and Buchwald amination. 5-Bromo-2,3-dihydro-1H-inden-1-one can be used in the research of obesity-related metabolic diseases .

Cat. No.	Product Name		Classification

HY-134811

KRAS G12D inhibitor 1		Alkynes
KRAS G12D inhibitor 1 (Example 243) is a KRAS G12D inhibitor, with an IC₅₀ of 0.4 nM. KRAS G12D inhibitor 1 exhibits an IC₅₀ of 0.8 nM for KRAS G12D-mediated ERK phosphorylation. KRAS G12D inhibitor 1 can be used for the study of cancers with KRAS G12D mutations, such as pancreatic ductal adenocarcinoma and colorectal cancer .

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