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Spectral studies

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By Targets:	Aurora Kinase (1) Drug Intermediate (1) FGFR (1) Fluorescent Dye (2) VEGFR (1)
By Research Areas:	Cancer (1) Infection (1) Metabolic Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114907

4',5'-Dibromofluorescein Eosinic acid; Solvent Red 72	Fluorescent Dye	Others
4',5'-Dibromofluorescein (Eosinic acid) is a fluorescein derivative that can used as a ligand for studying of protein properties by spectral analysis .

HY-69077

5-Bromo-1H-pyrazolo[3,4-b]pyridine	Drug Intermediate	Infection
5-Bromo-1H-pyrazolo[3,4-b]pyridine is a drug intermediate that can be used for the synthesis of sulfonamide derivatives.

HY-D1445

LysoSensor PDMPO 1 Publications Verification	Fluorescent Dye	Metabolic Disease
PDMPO, a lysosome pH indicator, is an excellent fluorescent acidotropic reagent for fluorescence imaging. PDMPO is a potent tool with which to study acidic organelles of live cells. PDMPO exhibits pH-dependent dual-excitation and dual-emission spectral peaks. PDMPO produces a blue fluorescence in weakly acidic organelles and shifts to yellow in more acidic lysosomes. (Abs=329 nm; Em=440/540 nm) .

HY-145601

Tinengotinib TT 00420	Aurora Kinase FGFR VEGFR	Cancer
Tinengotinib (TT00420) is an orally active, spectrally selective small molecule kinase inhibitor targeting Aurora A/B (IC₅₀=1.2-3.3 nM), FGFR1/2/3 (IC₅₀=1.5-3.5 nM), VEGFRs, JAK1/2 and CSF1R. Tinengotinib blocks Aurora kinase-mediated cell cycle progression (inducing G2/M arrest), inhibits FGFR/JNK-JUN signaling pathway and activates MEK/ERK-dependent apoptotic pathway. Tinengotinib has the activity of anti-tumor proliferation, inducing apoptosis, inhibiting angiogenesis and regulating tumor microenvironment. Tinengotinib can be used in the study of triple-negative breast cancer (TNBC), gallbladder cancer and tumor immune microenvironment .

Cat. No.	Product Name	Type

HY-114907

4',5'-Dibromofluorescein Eosinic acid; Solvent Red 72	Fluorescent Dyes/Probes
4',5'-Dibromofluorescein (Eosinic acid) is a fluorescein derivative that can used as a ligand for studying of protein properties by spectral analysis .

HY-D1445

LysoSensor PDMPO 1 Publications Verification	Fluorescent Dyes/Probes
PDMPO, a lysosome pH indicator, is an excellent fluorescent acidotropic reagent for fluorescence imaging. PDMPO is a potent tool with which to study acidic organelles of live cells. PDMPO exhibits pH-dependent dual-excitation and dual-emission spectral peaks. PDMPO produces a blue fluorescence in weakly acidic organelles and shifts to yellow in more acidic lysosomes. (Abs=329 nm; Em=440/540 nm) .

LysoSensor PDMPO

1 Publications Verification

Fluorescent Dyes/Probes

PDMPO, a lysosome pH indicator, is an excellent fluorescent acidotropic reagent for fluorescence imaging. PDMPO is a potent tool with which to study acidic organelles of live cells. PDMPO exhibits pH-dependent dual-excitation and dual-emission spectral peaks. PDMPO produces a blue fluorescence in weakly acidic organelles and shifts to yellow in more acidic lysosomes. (Abs=329 nm; Em=440/540 nm) .

5-Bromo-1H-pyrazolo[3,4-b]pyridine	Biochemical Assay Reagents
5-Bromo-1H-pyrazolo[3,4-b]pyridine is a drug intermediate that can be used for the synthesis of sulfonamide derivatives.

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