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Results for "

Renin+Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (7) Endogenous Metabolite (1) Isotope-Labeled Compounds (2) Reference Standards (1) Renin (36)
By Research Areas:	Cancer (10) Cardiovascular Disease (30) Metabolic Disease (3)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P5388

Renin inhibitor peptide,rat	Renin	Others
Renin inhibitor peptide,rat is a biological active peptide. (A specific rat renin inhibitor.)

HY-150963

Renin inhibitor-1	Renin	Cardiovascular Disease
Renin inhibitor-1 (compound 26) is a potent and orally active *renin* inhibitor with IC₅₀s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases .

HY-P2147

CGP 29287 Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-Ome	Renin	Others
CGP 29287 is a specific *renin* inhibitor .

HY-P2024

CP-85339	Renin	Cardiovascular Disease
CP-85339 is a tetrapeptide renin inhibitor .

HY-118033

SQ 30774	Renin	Cardiovascular Disease
SQ 30774 is a renin (renin) inhibitor. SQ 30774 has potent in vitro inhibitory effects in primates but not in rats, pigs, or dogs. And imidazolinol renin inhibitors also inhibit PRA and reduce arterial blood pressure in vivo .

HY-120756

PD125754	Renin	Cardiovascular Disease
PD125754 is an oligopeptide *renin* inhibitor (IC₅₀: 22 nM) .

HY-U00262

ACT 178882	Renin	Metabolic Disease
ACT 178882 is a new *Renin* inhibitor with an IC₅₀ of 1.4 nM.

HY-12176AS

Aliskiren-d6 hydrochloride CGP 60536-d₆ Hydrochloride; CGP60536Bd₆ Hydrochloride; SPP 100d₆(Hydrochloride)	Isotope-Labeled Compounds Renin	Cardiovascular Disease Cancer
Aliskiren-d₆ (hydrochloride) is is deuterium labeled Aliskiren, which is a direct renin inhibitor.

HY-120673

SQ 32970	Renin	Cardiovascular Disease
SQ 32970 is a tripeptidic *renin* inhibitor. SQ 32970 potently inhibits endothia protease .

HY-120586

SC-46944	Renin	Cardiovascular Disease
SC-46944 is an orally active renin inhibitor and can be used for study of hypertension .

HY-120455

PD 125967	Renin	Cardiovascular Disease Metabolic Disease
PD 125967 is an oligopeptide renin inhibitor. PD 125967 can be used to low blood pressure .

HY-50768

VTP-27999	Renin	Cardiovascular Disease
VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.

HY-76652

VTP-27999 Hydrochloride	Renin	Cardiovascular Disease
VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.

HY-P2097

L-363564	Renin	Cardiovascular Disease
L-363564 is a renin inhibitor. L-363564 can be used in cardiovascular disease related research .

HY-P2060

CGP 44099	Renin	Cardiovascular Disease
CGP 44099 is a renin inhibitor. CGP 44099 can be used to study the ischemic injury and reperfusion arrhythmias in rat hearts .

HY-129714

EMD 52297	Renin	Metabolic Disease
EMD 52297 is a *Renin* inhibitor, with acute hemodynamic and hormonal effects. EMD 52297 also acts as an ACE inhibitor .

HY-50769

VTP-27999 TFA	Renin	Cardiovascular Disease
VTP-27999 TFA is an alkyl amine Renin inhibitor; VTP-27999 TFA is useful for Hypertension and End-Organ Diseases.

HY-P2130

SR 42128	Renin	Cardiovascular Disease
SR 42128 is a potent *renin* inhibitor. SR 42128 potently inhibits primate renins whereas other animal renins are much less inhibited .

HY-105259

SR 43845	Renin	Cardiovascular Disease
SR 43845 is a *renin* inhibitor. SR 43845 decreases blood pressure and inhibits plasma renin activity. SR 43845 can be used for hypertension research .

HY-129695

PD 132002	Renin	Cardiovascular Disease
PD 132002 is an orally active, potent *renin* inhibitor. PD 132002 weakly inhibits pepsin. PD 132002 produces substantial reductions in blood pressure .

HY-12177S

Aliskiren-d6 hemifumarate CGP 60536 d₆ hemifumarate; CGP60536B d₆ hemifumarate; SPP 100 d₆ hemifumarate	Isotope-Labeled Compounds Renin Autophagy	Cardiovascular Disease Cancer
Aliskiren-d₆ (hemifumarate) is a deuterium labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor with an IC₅₀ of 1.5 nM .

HY-12176

Aliskiren Maximum Cited Publications 9 Publications Verification CGP 60536; CGP60536B; SPP 100	Renin Autophagy	Cardiovascular Disease Cancer
Aliskiren is an orally active, highly potent and selective *renin* inhibitor, with IC₅₀ of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .

HY-12176B

Aliskiren fumarate CGP 60536 fumarate; CGP60536B fumarate; SPP 100 fumarate	Renin Autophagy	Cardiovascular Disease Cancer
Aliskiren fumarate is an orally active, highly potent and selective *renin* inhibitor, with IC₅₀ of 1.5 nM. Aliskiren fumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .

HY-136676

Cgp 38560 methanesulfonate	Renin	Cancer
Cgp 38560 methanesulfonate is a well-tolerated renin inhibitor. Cgp 38560 methanesulfonate caused a dose-dependent decrease in angiotensin II and plasma renin activity, and a dose-dependent increase in active renin.

HY-12176A

Aliskiren hydrochloride CGP 60536 hydrochloride; CGP60536B hydrochloride; SPP 100 hydrochloride	Renin Autophagy	Cardiovascular Disease Cancer
Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride is an orally active and selective *renin* inhibitor, with IC₅₀ of 1.5 nM. Aliskiren hydrochloride can be used for the research of hypertension, cardiovascular diseases and cancer cachexia ^- .

HY-12177

Aliskiren hemifumarate Maximum Cited Publications 9 Publications Verification CGP 60536 hemifumarate; CGP60536B hemifumarate; SPP 100 hemifumarate	Renin Autophagy	Cardiovascular Disease Cancer
Aliskiren (CGP 60536; CGP60536B; SPP 100) hemifumarate is an orally active and selective *renin* inhibitor, with IC₅₀ of 1.5 nM. Aliskiren hemifumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .

HY-12176R

Aliskiren (Standard) CGP 60536 (Standard); CGP60536B (Standard); SPP 100 (Standard)	Reference Standards Renin Autophagy	Cardiovascular Disease Cancer
Aliskiren (Standard) is the analytical standard of Aliskiren. This product is intended for research and analytical applications. Aliskiren is an orally active, highly potent and selective *renin* inhibitor, with IC₅₀ of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .

HY-151111

SPH3127	Renin	Cardiovascular Disease
SPH3127 (DRI 18) is a novel, highly potent, and orally active direct renin inhibitor (recombinant human-renin IC₅₀=0.4 nM, human plasma renin activity IC₅₀=0.45 nM). SPH3127 shows antihypertensive effect and can be used in essential hypertension research .

HY-106113

Ditekiren U 71038	Renin	Cardiovascular Disease
Ditekiren (U 71038) is a pseudohexapeptide *renin* inhibitor. *Renin* is an enzyme that plays a crucial role in regulating blood pressure and fluid balance. By inhibiting the activity of *renin*, ditekiren slows down the formation of angiotensin II, a potent vasoconstrictor that can raise blood pressure. Ditekiren can be used for research in the field of blood pressure reduction .

HY-129412

A-74273	Renin	Cardiovascular Disease
A-74273 is an orally active peptide *renin* inhibitor (IC₅₀=3.1 nM). A-74273 competitively binds to the active site of *renin*, preventing angiotensinogen from being converted to ANG-I, thereby reducing the level of angiotensin II. A-74273 can be used in the study of diseases such as hypertension .

HY-12177R

Aliskiren hemifumarate (Standard)	Renin Autophagy	Cardiovascular Disease Cancer
Aliskiren (hemifumarate) (Standard) is the analytical standard of Aliskiren (hemifumarate). This product is intended for research and analytical applications. Aliskiren (CGP 60536; CGP60536B; SPP 100) hemifumarate is an orally active and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren hemifumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia .

HY-A0184

Remikiren Ro 42-5892; Ro 42-5892/001	Renin	Cardiovascular Disease
Remikiren (Ro 42-5892) is an orally active and highly specific *renin* inhibitor. Remikiren specifically inhibits human reninand human plasma *renin* with IC₅₀ values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension .

HY-129737

A-62198	Endogenous Metabolite	Cardiovascular Disease
A-62198 is a potent and selective renin inhibitor with antihypertensive activity. A-62198 reduces mean arterial pressure (MAP) in anesthetized, salt-deprived monkeys in a dose-dependent manner. A-62198 induced MAP reduction in normal monkeys that reached statistical significance at the highest dose and significantly inhibited plasma renin activity (PRA) at all doses .

HY-118185

SQ 31844	Renin	Others
SQ 31844 is a novel renin inhibitor belonging to the imidazolidinol class. This compound, which contains an imidazole ring in its active site binding group, has potent in vitro inhibition of primate renin, but not rat, pig, or dog renin. In conscious, sodium-deprived cynomolgus monkeys, both compounds produced dose-related inhibition of plasma renin activity (PRA) over a dose range of 0.001 to 1.0 μmol/kg, administered intravenously, with complete inhibition observed at the highest dose. However, a reduction in blood pressure was only observed when 10 μmol/kg was administered intravenously or by infusion. In sodium-replete monkeys, SQ 30774 inhibited the increase in arterial blood pressure and PRA following administration of exogenous monkey renin. When the compounds were administered orally at 50 μmol/kg, only SQ 31844 significantly inhibited PRA (80%). In summary, the imidazolidinol renin inhibitors have potent inhibitory effects on renin in vitro and inhibit PRA and reduce arterial blood pressure in vivo.

HY-117913

ES-8891	Renin	Cardiovascular Disease
ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis .

HY-12172

MK-8141 ACT-077825	Renin	Cardiovascular Disease
MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA). This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition.

HY-19145

PD-134672 CI-992	Renin	Cancer
PD-134672 (CI-992) is a renin inhibitor containing a 2-amino-4-thiazolyl substituent. PD-134672 potently inhibits monkey renin in vitro and only weakly inhibits the related aspartic protease bovine feline hepsin D. The compound exhibits oral hypotensive activity in hyperreninemic normotensive monkeys. Based on its superior efficacy and long-lasting effects in vitro and in the normotensive macaque model, PD-134672 was selected for further evaluation in renal hypertensive monkeys.

Cat. No.	Product Name

HY-L145

Antihypertensive Compound Library	761 compounds
The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death. Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs). MCE offers a unique collection of 761 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

Antihypertensive Compound Library

761 compounds

The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death.

Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs).

MCE offers a unique collection of 761 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

Renin inhibitor peptide,rat	Renin	Others
Renin inhibitor peptide,rat is a biological active peptide. (A specific rat renin inhibitor.)

CGP 29287 Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-Ome	Renin	Others
CGP 29287 is a specific *renin* inhibitor .

CP-85339	Renin	Cardiovascular Disease
CP-85339 is a tetrapeptide renin inhibitor .

L-363564	Renin	Cardiovascular Disease
L-363564 is a renin inhibitor. L-363564 can be used in cardiovascular disease related research .

CGP 44099	Renin	Cardiovascular Disease
CGP 44099 is a renin inhibitor. CGP 44099 can be used to study the ischemic injury and reperfusion arrhythmias in rat hearts .

SR 42128	Renin	Cardiovascular Disease
SR 42128 is a potent *renin* inhibitor. SR 42128 potently inhibits primate renins whereas other animal renins are much less inhibited .

Cat. No.	Product Name	Chemical Structure

HY-12176AS

Aliskiren-d6 hydrochloride
Aliskiren-d₆ (hydrochloride) is is deuterium labeled Aliskiren, which is a direct renin inhibitor.

HY-12177S

Aliskiren-d6 hemifumarate
Aliskiren-d₆ (hemifumarate) is a deuterium labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor with an IC₅₀ of 1.5 nM .

Cat. No.	Product Name		Classification

HY-129737

A-62198		Azide
A-62198 is a potent and selective renin inhibitor with antihypertensive activity. A-62198 reduces mean arterial pressure (MAP) in anesthetized, salt-deprived monkeys in a dose-dependent manner. A-62198 induced MAP reduction in normal monkeys that reached statistical significance at the highest dose and significantly inhibited plasma renin activity (PRA) at all doses .

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