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PROTAC BCL6 Degrader-2

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-178803
    PROTAC BCL6 Degrader-2

    		PROTACs BCL6 Cancer
    PROTAC BCL6 Degrader-2 (Compound A19) is an orally active, selective BCL6 PROTAC degrader (DC50s: 34 pM in OCI-LY1 cells and 0.45 nM in HEK293T cells). PROTAC BCL6 Degrader-2 promotes the ubiquitination and degradation of BCL6. PROTAC BCL6 Degrader-2 exhibits anticancer activity against BCL6-dependent diffuse large B-cell lymphoma (Pink: BCL6 ligand (HY-178804); Blue: E3 ligase ligand (HY-W087383); E3 ligase ligand + linker (HY-W998306)) .
    PROTAC BCL6 Degrader-2

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