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Pathways Recommended: Membrane Transporter/Ion Channel
Results for "

Membrane selectivity

" in MedChemExpress (MCE) Product Catalog:

307

Inhibitors & Agonists

2

Screening Libraries

13

Fluorescent Dye

9

Biochemical Assay Reagents

36

Peptides

1

Inhibitory Antibodies

23

Natural
Products

18

Isotope-Labeled Compounds

1

Click Chemistry

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-70068
    SB-408124

    		Orexin Receptor (OX Receptor) Neurological Disease Endocrinology
    SB-408124 is a non-peptide OX1 receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor .
    SB-408124
  • HY-151813
    NNMT-IN-4

    		Fluorescent Dye Cancer
    NNMT-IN-4 (compound 38) is a selective, uncompetitive and membrane permeability nicotinamide N-methyltransferase (NNMT) inhibitor with IC50 values of 42 and 38 nM in vitro biochemical and cell-based assays, respectively. NNMT-IN-4 shows favorable PK/PD and safety profiles as well as excellent oral bioavailability and pharmaceutical properties. NNMT-IN-4 can be used as a vivo chemical probe of NNMT .
    NNMT-IN-4
  • HY-D0127
    Merocyanin 540

    		Fluorescent Dye Others
    Merocyanin 540 is a fluorescent membrane probe that selectively stains the membranes of a wide variety of electrically excitable cells, but not those of nonexcitable cells (Ex/Em: 540/580 nm) .
    Merocyanin 540
  • HY-137172
    ETH 157

    		Sodium Channel Others
    ETH 157 is a Na + ionophore that induces a Na +/Ca 2+ selectivity in membranes .
    ETH 157
  • HY-D2346
    HBmito Crimson
    3 Publications Verification

    		 Fluorescent Dye Others
    HBmito Crimson is a deep red fluorescent probe (λex: 658 nm, λem: 678 nm) for the inner mitochondrial membrane. HBmito Crimson is a cell membrane-permeable probe with high selectivity for the mitochondrial inner membrane, suitable for specific fluorescence staining of the inner mitochondrial membrane in living cells. HBmito Crimson has high photostability and brightness, suitable for long-term dynamic fluorescence imaging.
    HBmito Crimson
  • HY-P5753A
    JB-95 acetate

    		Bacterial Infection
    JB-95 acetate, a β-hairpin macrocyclic peptide, exhibits potent antimicrobial activity against Escherichia coli. JB-95 acetate can selectively disrupt the outer membrane but not the inner membrane of E. coli .
    JB-95 acetate
  • HY-P5753
    JB-95

    		Bacterial Infection
    JB-95, a β-hairpin macrocyclic peptide, exhibits potent antimicrobial activity against Escherichia coli. JB-95 can selectively disrupt the outer membrane but not the inner membrane of E. coli .
    JB-95
  • HY-70068R
    SB-408124 (Standard)

    		Orexin Receptor (OX Receptor) Neurological Disease Endocrinology
    SB-408124 (Standard) is the analytical standard of SB-408124. This product is intended for research and analytical applications. SB-408124 is a non-peptide OX1 receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor .
    SB-408124 (Standard)
  • HY-P11220
    Hs02

    		Bacterial Interleukin Related Infection
    Hs02 is a cationic amphiphilic antibacterial peptide derived from human proteins, and it is the membrane-active module of the core chimeric peptide Chim2. Hs02 exhibits broad-spectrum and potent antibacterial activity against various human pathogenic bacteria with the MIC for Staphylococcus aureus and Escherichia coli of as low as 2 μM, and the MBC is 2-4 μM. Hs02 primarily kills bacteria by disrupting the integrity of the bacterial cell membrane, and it has a relatively low selectivity for eukaryotic cell membranes. Hs02 induces the release of IL-12 but does not induce the release of IL-6, indicating its potential for pro-inflammatory or immune activation. Hs02 can be used in antibacterial and immunomodulatory research .
    Hs02
  • HY-D2318
    Flipper-TR 5

    		Fluorescent Dye Others
    Flipper-TR 5 is a Flipper probe that contains a terminal carboxylate for retention on the plasma membrane. Flipper-TR 5 can selectively label the plasma membrane and exhibits excellent mechanosensitivity, negligible cytotoxicity, and manageable phototoxicity .
    Flipper-TR 5
  • HY-123370
    FR-167356

    		Proton Pump Metabolic Disease Cancer
    FR-167356 is a potent, orally active and selective vacuolar ATPase inhibitor with IC50 values of 170, 220, 370, and 1200 nM for osteoclast plasma membranes, macrophage microsomes, renal brush border membranes, and liver lysosomal membranes, respectively. FR-167356 inhibits bone resorption and ovariectomy-induced bone loss .
    FR-167356
  • HY-15084
    Dizocilpine maleate
    35+ Cited Publications

    (+)-MK 801 Maleate

    		 iGluR Neurological Disease
    Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
    Dizocilpine maleate
  • HY-15720
    H-1152
    3 Publications Verification

    		 ROCK Neurological Disease
    H-1152 is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.
    H-1152
  • HY-15720A
    H-1152 dihydrochloride
    3 Publications Verification

    		 ROCK Neurological Disease
    H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2.
    H-1152 dihydrochloride
  • HY-101609
    Lesopitron dihydrochloride

    E4424

    		 5-HT Receptor Neurological Disease
    Lesopitron dihydrochloride is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes.
    Lesopitron dihydrochloride
  • HY-101998
    CTP inhibitor

    		Mitochondrial Metabolism Metabolic Disease
    CTP inhibitor (Compound 792949) is a potent and selective CTP inhibitor. CTP inhibitor inhibits the plasma membrane citrate transporter (PMCT) .
    CTP inhibitor
  • HY-D1641
    5,5'-Dimethyl BAPTA tetrapotassium

    		Fluorescent Dye Others
    5,5'-Dimethyl BAPTA tetrapotassium is a water-soluble, extracellular membrane metal chelator with relative selectivity for calcium ions .
    5,5'-Dimethyl BAPTA tetrapotassium
  • HY-135056
    MitoTracker Green FM
    15+ Cited Publications

    		 Fluorescent Dye Others
    Mito-Tracker Green is a green fluorescent dye that selectively accumulates in the mitochondrial matrix. MitoTracker Green FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues, allowing staining of mitochondrial membrane potential independent of membrane potential. Excitation/emission wavelength 490/523 nm.
    MitoTracker Green FM
  • HY-126220
    KMG-301AM

    		Fluorescent Dye Others
    KMG-301AM is the acetoxy methyl esterified form of KMG-301. KMG-301AM successfully accumulates in mitochondria and then it is hydrolyzed to KMG-301. KMG-301 is an Mg 2+-selective fluorescent probe functional in mitochondria in intact cells. Since the mitochondrial membrane is impermeable to KMG-301, it is not released upon depolarization of the mitochondrial membrane potential. KMG-301 can indicate changes in mitochondrial Mg2+ concentration and shows Mg 2+ transport across the mitochondrial membrane in the early phases of a cellular model .
    KMG-301AM
  • HY-101833
    YM-264

    		Platelet-activating Factor Receptor (PAFR) Inflammation/Immunology
    YM-264 is a selective, potent and orally active platelet-activating factor (PAF) antagonist with a pKi value of 8.85 for rabbit platelet membranes.
    YM-264
  • HY-171796
    Bromomonilicin

    		Fungal Infection
    Bromomonilicin is a selective fungal cell membrane inhibitor. Bromomonilicin exerts antifungal activity by disrupting fungal cell membrane integrity. Bromomonilicin is promising for research of plant pathogenic fungal infections (e.g., Monilinia fructicola-induced brown rot) and superficial mycoses (e.g., dermatophyte infections) .
    Bromomonilicin
  • HY-121872
    DP-b99

    		Others Neurological Disease
    DP-b99 is a chelator of zinc and calcium ions that acts selectively within cell membranes and has neuroprotective properties in animal models of stroke.
    DP-b99
  • HY-N10661
    Ipomoeassin F

    Ipom-F

    		 SARS-CoV Infection Cancer
    Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .
    Ipomoeassin F
  • HY-P5712
    Gramicidin S
    1 Publications Verification

    Gramicidin soviet

    		 Antibiotic Bacterial Na+/K+ ATPase Infection
    Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na +/K +-ATPase, tobacco leaf plasma membrane Mg 2+/K +-ATPase, and rat heart plasma membrane Ca 2+-ATPase, respectively .
    Gramicidin S
  • HY-126220A
    KMG-301AM TFA

    		Fluorescent Dye Others
    KMG-301AM TFA is the acetoxy methyl esterified form of KMG-301. KMG-301AM TFA successfully accumulates in mitochondria and then it is hydrolyzed to KMG-301. KMG-301 is an Mg 2+-selective fluorescent probe functional in mitochondria in intact cells. Since the mitochondrial membrane is impermeable to KMG-301, it is not released upon depolarization of the mitochondrial membrane potential. KMG-301 can indicate changes in mitochondrial Mg2+ concentration and shows Mg 2+ transport across the mitochondrial membrane in the early phases of a cellular model .
    KMG-301AM TFA
  • HY-100821
    2,4-Dihydroxyphenylacetylasparagine

    		Bacterial Infection
    2,4-Dihydroxyphenylacetylasparagine is a potent and selective antagonist of glutamate. 2,4-Dihydroxyphenylacetylasparagine inhibits glutamate binding to rat brain synaptic membranes .
    2,4-Dihydroxyphenylacetylasparagine
  • HY-P5731
    Bac7(1-35)

    		Bacterial Infection
    Bac7(1-35) is a proline-rich antimicrobial peptide, selective for Gram-negative bacteria, which acts intracellularly after membrane translocation .
    Bac7(1-35)
  • HY-D2323
    ER PhotoFlipper 32

    		Fluorescent Dye Others
    ER-PhotoFlipper 32 is a ER tracker. ER-PhotoFlipper 32 can selectively label the inner leaflet of the plasma membrane with Flipper-TR 5 (HY-D2318). The ER-tracker attaches the PhotoFlipper covalently to the outer surface of the ER. ER-PhotoFlipper 32 can be applied to access plasma membrane asymmetry .
    ER PhotoFlipper 32
  • HY-103339
    VDM11

    		FAAH MAGL Neurological Disease
    VDM11 is a potent and selective anandamide membrane transporter (AMT) inhibitor . VDM11 inhibits FAAH and MAGL and may act as an alternative FAAH substrate .
    VDM11
  • HY-10114
    TGX-221
    15+ Cited Publications

    		 PI3K Cancer
    TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, used for cancer treatment.
    TGX-221
  • HY-131766
    2'-O-Me-cAMP

    2'-O-Methyladenosine-3',5'-cyclic monophosphate

    		 Ras Others
    2'-O-Me-cAMP is an analogue of natural signal molecule cAMP and a selective stimulator of the exchange factors activated by cAMP (Epac) with low membrane permeability .
    2'-O-Me-cAMP
  • HY-P10862
    AH-D peptide

    		Virus Protease Infection Cancer
    AH-D peptide is an antiviral peptide that selectively disrupts membrane structures within the size range of exosomes, inducing T-EXO depletion and enhancing cancer immunotherapy .
    AH-D peptide
  • HY-15249
    JZL 184
    5 Publications Verification

    		 MAGL Neurological Disease
    JZL 184 is a potent, selective and irreversible MAGL inhibitor that blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes (IC50 of 8 nM). JZL 184 displays >300-fold selectivity for MAGL over FAAH .
    JZL 184
  • HY-P10862A
    AH-D peptide TFA

    		Virus Protease Infection Cancer
    AH-D peptide TFA is an antiviral peptide that selectively disrupts membrane structures within the size range of exosomes, inducing T-EXO depletion and enhancing cancer immunotherapy .
    AH-D peptide TFA
  • HY-101336
    RS 17053 hydrochloride

    RS-17053

    		 Adrenergic Receptor Metabolic Disease Endocrinology
    RS 17053 hydrochloride is a potent and selective α1A adrenoceptor antagonist, with a pKi value of 9.1 in native cell membrane and a pA2 value of 9.8 in functional assays.
    RS 17053 hydrochloride
  • HY-76612
    SB-408124 Hydrochloride

    		Orexin Receptor (OX Receptor) Neurological Disease Endocrinology
    SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor .
    SB-408124 Hydrochloride
  • HY-176746
    CMLD009688

    		Fungal Infection
    CMLD009688 is a cationic amphiphilic antifungal agent. CMLD009688 selectively inhibits plant pathogenic fungi such as Fusarium graminearum. CMLD009688 interacts with biological membranes, perturbing vacuolar and mitochondrial membrane structures to induce fungal cell death. CMLD009688 is promising for research of plant fungal diseases (e.g., wheat head blight, gray mold) .
    CMLD009688
  • HY-17362
    Vancomycin hydrochloride
    80+ Cited Publications

    		 Bacterial Autophagy Antibiotic Infection Cancer
    Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis.
    Vancomycin hydrochloride
  • HY-136460
    Calcium ionophore I

    ETH 1001

    		 Calcium Channel Others
    Calcium ionophore I (ETH 1001) is a selective Ca 2+ ionophore for biological membranes. Calcium ionophore I can be used in Ca2+-selective microelectrodes that can be used for quantitative intracellular measurements of resting Ca2+-activities and of slowly changing Ca2+-levels .
    Calcium ionophore I
  • HY-128536
    KMG-104AM

    		Fluorescent Dye Others
    KMG-104AM, a selective fluorescein-derived magnesium fluorescent membrane-permeable probe, successfully incorporates into PC12 cells and is used to Intracellular 3D Mg 2+ Imaging .
    KMG-104AM
  • HY-19405
    UK-224671

    		Neurokinin Receptor Others
    UK-224671 is a potent and selective NK2 receptor antagonist. UK-224671 is affected by P-gp efflux and poor intrinsic membrane permeability, resulting in low oral bioavailability .
    UK-224671
  • HY-D1694
    LysoTracker Yellow HCK 123

    		Fluorescent Dye Others
    LysoTracker Yellow HCK 123 is a potent yellow membrane-permeable fluorescent probe. LysoTracker Yellow HCK 123 is a weakly basic amine that selectively accumulates in cellular compartments with low luminal pH .
    LysoTracker Yellow HCK 123
  • HY-14137
    Rimonabant Hydrochloride
    10+ Cited Publications

    SR 141716A Hydrochloride

    		 Cannabinoid Receptor Bacterial Infection Metabolic Disease Cancer
    Rimonabant Hydrochloride (SR 141716A Hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant Hydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).
    Rimonabant Hydrochloride
  • HY-P11310
    PSMA-1-SMCC

    		PSMA Cancer
    PSMA-1-SMCC is a selective binding agent targeting Prostate-Specific Membrane Antigen (PSMA). PSMA-1-SMCC is promising for research of targeted imaging for prostate cancer .
    PSMA-1-SMCC
  • HY-143896
    STING agonist-7

    		STING Cancer
    STING agonist-7 is a non-nucleotide STING agonist. STING agonist-7 binds selectively to mouse STING but not human STING. STING agonist-7 penetrates cell membrane poorly .
    STING agonist-7
  • HY-134389
    6-Phe-cAMP

    N6-Phenyladenosine-3',5'-cyclic monophosphate

    		 PKA Cancer
    6-Phe-cAMP is a site-selective and highly membrane-permeant activator of protein kinase A (PKA), with a strong preference for site A of both isozymes. 6-Phe-cAMP can undergo phosphorothioate modification .
    6-Phe-cAMP
  • HY-117410
    Vipivotide tetraxetan
    15+ Cited Publications

    PSMA-617

    		 Drug-Linker Conjugates for ADC Cancer
    Vipivotide tetraxetan (PSMA-617) is a high potent prostate-specific membrane antigen (PSMA) inhibitor, with a Ki of 0.37 nM. Vipivotide tetraxetan (PSMA-617) is designed consisting of three components: the pharmacophore Glutamate-urea-Lysine, the chelator DOTA able to complex both 68Ga or 177Lu, and a linker connecting these two entities. Glutamate-urea-Lysine is the selective pharmacophore to bind to prostate specific membrane antigen.
    Vipivotide tetraxetan
  • HY-102064
    SR 57227A
    1 Publications Verification

    		 5-HT Receptor Neurological Disease
    SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects .
    SR 57227A
  • HY-14136
    Rimonabant
    10+ Cited Publications

    SR141716

    		 Cannabinoid Receptor Bacterial Infection Metabolic Disease Cancer
    Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).
    Rimonabant
  • HY-136615
    5-Hydroxydecanoate sodium

    		Potassium Channel Neurological Disease
    5-Hydroxydecanoate sodium is a selective ATP-sensitive K + (KATP) channel blocker (IC50 of ~30 μM). 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase and has antioxidant activity .
    5-Hydroxydecanoate sodium

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