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MMP12+Inhibitors

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156963
    Aderamastat

    FP-025

    		 MMP Inflammation/Immunology
    Aderamastat (FP-025) is an orally active, selective MMP-12 inhibitor. Aderamastat provides protection against house dust mite (HDM)-sensitized allergic asthma. Aderamastat can be used in the research of respiratory diseases, including chronic inflammatory airway diseases and pulmonary fibrosis .
    Aderamastat
  • HY-12093
    MMP408

    		MMP Others Inflammation/Immunology
    MMP408 is a potent and selective MMP-12 inhibitor that is derived from a potent matrix metalloprotease-2 and -13 inhibitor via lead optimization. MMP408 can block rhMMP-12-induced lung inflammation in vivo. MMP408 can be studied in research on COPD .
    MMP408
  • HY-135517A
    (2R)-RXP470.1

    (2R)-RXP-470

    		 MMP Cardiovascular Disease
    (2R)-RXP470.1 ((2R)-RXP-470) is the (2R)-isomer of RXP470.1 (HY-135517). RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a Ki of 0.2 nM against human MMP-12 .
    (2R)-RXP470.1
  • HY-135517
    RXP470.1

    RXP-470

    		 MMP Cardiovascular Disease
    RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a Ki of 0.2 nM against human MMP-12. RXP470.1 is 2 to 4 orders of magnitude less potent against other MMPs. RXP470.1 significantly reduces atherosclerotic plaque cross-sectional area in mouse. RXP470.1 results in less complex plaques with increased smooth muscle cell:macrophage ratio, less macrophage apoptosis, increased cap thickness, smaller necrotic cores, and decreased incidence of calcification .
    RXP470.1
  • HY-14155
    MMP145

    		MMP Inflammation/Immunology
    MMP145 (compound 27) is a potent, selective and orally active MMP-12 inhibitor. MMP145 is effective in inflammation and asthma reasearch .
    MMP145
  • HY-130391
    MMP12-IN-3

    		MMP Inflammation/Immunology
    MMP12-IN-3 (compound 32) is a potent MMP12 inhibitor with an IC50 value of 4.9 nM. MMP12-IN-3 has the potential for the research of chronic respiratory diseases such as emphysema .
    MMP12-IN-3
  • HY-120944
    BAY-7598

    		MMP Inflammation/Immunology
    BAY-7598, a chemical probe, is a potent, orally bioavailable, and selective MMP12 inhibitor with IC50s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively .
    BAY-7598
  • HY-12093A
    (R)-MMP408

    		MMP Inflammation/Immunology
    (R)-MMP408 is an isomer of MMP408 (HY-12093). MMP408 is a potent and selective MMP-12 inhibitor that is derived from a potent matrix metalloprotease-2 and -13 inhibitor via lead optimization. MMP408 can block rhMMP-12-induced lung inflammation in vivo. MMP408 can be studied in research on COPD .
    (R)-MMP408
  • HY-171804
    Linvemastat

    FP-020

    		 MMP Inflammation/Immunology
    Linvemastat (Compound FC-4) is an orally active MMP-12 inhibitor (IC50: < 10  nM) with high selectivity of MMP-1, -2, -3, -7, -9, -10 and -14. Linvemastat significantly attenuates lung fibrosis in Bleomycin (HY-108345) induced unilateral lung fibrosis mice model and potently reduces kidney damage, interstitial inflammation or fibrosis in kidney fibrosis model of unilateral ureteral occlusion. Linvemastat can be used for inflammatory diseases research, such as idiopathie pulmonary fibrosis (IPF), inflammatory bowel disease (IBD) and asthma .
    Linvemastat

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