MDMX

By Targets:	Apoptosis (4) E1/E2/E3 Enzyme (2) HDAC (1) Ligands for E3 Ligase (1) MDM-2/p53 (11) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (13)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16664

SJ-172550 1 Publications Verification	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
SJ-172550 is a small molecule inhibitor of *MDMX; competes for the wild type p53 peptide binding to MDMX* with an EC₅₀ of 5 μM.

HY-123950

MMRi64	MDM-2/p53 Apoptosis	Cancer
MMRi64 disrupts *Mdm2-MdmX* interactions. MMRi64 downregulates Mdm2 and MdmX in leukemia cells. MMRi64 induces p53 accumulation, and induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells. MMRi64 can be used for cancer research .

HY-P4210

Sulanemadlin ALRN-6924; MP-4897	MDM-2/p53	Cancer
Sulanemadlin (ALRN-6924) is a potent and cell-permeating p53-based peptidomimetic macrocycles. Sulanemadlin is a inhibitor of the p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. Sulanemadlin can be used for cancers research .

HY-120086

RO-5963 1 Publications Verification	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
RO-5963 is a dual p53-MDM2 and *p53-MDMX* inhibitor with IC₅₀s of ~17 nM and ~24 nM, respectively .

HY-149250

MDMX/MDM2-IN-2	MDM-2/p53 Apoptosis	Cancer
MDMX/MDM2-IN-2 is a potent *p53-MDM2/MDMX* dual inhibitors with K_is of 0.23 μM and 2.45 μM for MDM2 and MDMX, respectively. MDMX/MDM2-IN-2 inhibits the binding of p53 and MDM2 proteins. MDMX/MDM2-IN-2 restores the function of p53 and enables cell cycle arrest and apoptosis. MDMX/MDM2-IN-2 inhibits cell migration and invasion. MDMX/MDM2-IN-2 has antitumor activity .

HY-141584

ATSP-7041	MDM-2/p53	Cancer
ATSP-7041, a selective dual peptide inhibitor of MDM2 and *MDMX*, effectively reactivates the p53 tumor suppressor pathway in a mechanism-dependent manner in p53-positive cancers .

HY-107466

WK298	MDM-2/p53	Cancer
WK298 is a potent inhibitor of the MDM2/MDMX-p53 interaction with good anti-tumor activity. WK298 can fully activate the p53 pathway by inhibiting the binding of MDM2 and MDMX to p53. The development of WK298 benefited from a deep understanding of the key elements of the p53-MDM2/MDMX interaction structure .

HY-P10286

Phage-derived 12/1 peptide	MDM-2/p53	Cancer
Phage-derived 12/1 peptide exhibits antitumor activity by targeting MDM2 and *MDMX, an thus disrupt the MDM2-p53 and MDMX-p53 interaction, with IC₅₀* of 0.15 and 1.25 μM .

HY-164550

YF438	HDAC	Cancer
YF438 is an HDAC inhibitor with effective anticancer activity both in vitro and in vivo. YF438 inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2-MDMX, and promoting the degradation of MDM2 .

HY-148106

MEL23	Ligands for E3 Ligase	Cancer
MEL23 is a MDM2 E3 ligase inhibitor that blocks the E3 ligase activity of the MDM2-MDMX complex. MEL23 inhibits Mdm2 and p53 ubiquitination in cells, reduce viability of cells with wild-type p53. MEL23 stabilizes MDM2 via a mechanism independent of p53 transcription .

HY-RS16923

Mdm4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mdm4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mdm4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mdm4 Mouse Pre-designed siRNA Set A Mdm4 Mouse Pre-designed siRNA Set A

HY-14714

NSC-207895 1 Publications Verification XI-006	MDM-2/p53	Cancer
NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator .

HY-163275

MDM2-IN-24	MDM-2/p53 Apoptosis	Cancer
MDM2-IN-24 (compound A3f) exhibits MDM2-inhibiting and *MDMX*-activating properties in triple-negative breast cancer (TNBC) cells, with apoptotic and anti-proliferative activities .

HY-108638

NSC 146109 hydrochloride 2 Publications Verification	MDM-2/p53 Apoptosis	Cancer
NSC 146109 hydrochloride is a small-molecule p53 activator that target *MDMX* and can be used for breast cancer research. NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes .

HY-RS08267

MDM4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MDM4 Human Pre-designed siRNA Set A contains three designed siRNAs for MDM4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MDM4 Human Pre-designed siRNA Set A MDM4 Human Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P4210

Sulanemadlin ALRN-6924; MP-4897	MDM-2/p53	Cancer
Sulanemadlin (ALRN-6924) is a potent and cell-permeating p53-based peptidomimetic macrocycles. Sulanemadlin is a inhibitor of the p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. Sulanemadlin can be used for cancers research .

HY-141584

ATSP-7041	MDM-2/p53	Cancer
ATSP-7041, a selective dual peptide inhibitor of MDM2 and *MDMX*, effectively reactivates the p53 tumor suppressor pathway in a mechanism-dependent manner in p53-positive cancers .

HY-P10286

Phage-derived 12/1 peptide	MDM-2/p53	Cancer
Phage-derived 12/1 peptide exhibits antitumor activity by targeting MDM2 and *MDMX, an thus disrupt the MDM2-p53 and MDMX-p53 interaction, with IC₅₀* of 0.15 and 1.25 μM .

Cat. No.	Compare	Product Name	Species	Source

HY-P74756

	*MDM4/MDMX* Protein, Human (His)** Protein Mdm4; Protein MDMX; MDM4; MDMX	Human	E. coli
	MDM4/MDMX proteins cooperate with MDM2 to regulate TP53 (p53) and inhibit the transcriptional activation domains of p53 and p73. This hinders their ability to induce cell cycle arrest and apoptosis. MDM4/MDMX Protein, Human (His) is the recombinant human-derived MDM4/MDMX protein, expressed by E. coli , with N-His labeled tag.

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HY-P85272

	MDMX Antibody (YA4964) MDM4; MDMX; Protein Mdm4; Double minute 4 protein; Mdm2-like p53-binding protein; Protein MDMX; p53-binding protein Mdm4	WB, IHC-P, ICC/IF, ELISA	Human
	MDMX Antibody (YA4964) is a mouse-derived and non-conjugated monoclonal antibody, targeting to MDMX. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

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HY-RS16923

Mdm4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Mdm4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mdm4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS08267

MDM4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MDM4 Human Pre-designed siRNA Set A contains three designed siRNAs for MDM4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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