Search Result

Results for "

MAP kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MAP3K (7) MAP4K (24) MAPKAPK2 (MK2) (6) MEK (9) MNK (5) AAK1 (2) Akt (2) Androgen Receptor (5) Apoptosis (14) Aurora Kinase (1) Autophagy (10) Bcr-Abl (2) c-Myc (1) CaMK (1) Caspase (1) CDK (7) COX (1) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (2) Drug Derivative (1) Enterovirus (2) Ephrin Receptor (1) ERK (5) Farnesyl Transferase (1) Ferroptosis (2) FGFR (1) FLT3 (1) Fluorescent Dye (1) Histone Methyltransferase (1) HIV (2) Integrin (2) Interleukin Related (2) IRAK (1) Itk (1) LIM Kinase (LIMK) (2) Liposome (1) Lipoxygenase (1) MDM-2/p53 (1) MELK (1) Microtubule/Tubulin (1) Mitosis (1) Molecular Glues (6) NF-κB (1) NO Synthase (1) Organoid (4) p38 MAPK (36) PAK (1) Parasite (1) PDGFR (1) Phosphatase (1) Phosphodiesterase (PDE) (2) PI3K (3) PI4K (1) PKC (2) PPAR (2) PROTACs (4) Raf (1) Ras (1) Reference Standards (5) Salt-inducible Kinase (SIK) (3) Ser/Thr Kinase (1) Sirtuin (2) Src (2) STAT (2) STK33 (1) TGF-β Receptor (1) TNF Receptor (1) Toll-like Receptor (TLR) (2) Trk Receptor (1) ULK (3) Wee1 (1)
By Research Areas:	Cancer (60) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (35) Metabolic Disease (4) Neurological Disease (10)
Oligonucleotides:	Aptamers (1) Phospholipids (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: MAP3K MAP4K MEK MNK MAPKAPK2 (MK2) ASK1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112389

*p38 MAP* Kinase Inhibitor III** 2 Publications Verification	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an ₅₀ of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with ₅₀ values of 0.37 μM and 0.044 μM, respectively .

HY-49073

*p38 MAP* Kinase Inhibitor Ⅵ**	p38 MAPK	Cancer
p38 MAP Kinase Inhibitor VI (compound c32) is a p38 MAPK inhibitor with an inhibition rate of 24% .

HY-143212

18:0-22:6 DG 1-Stearoyl-2-docosahexaenoyl-sn-glycerol	Liposome p38 MAPK	Others
18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) is a diacylglycerol that can bind to RasGRP and modulate **MAP kinases** activation .

HY-112401

*p38 MAP* Kinase Inhibitor IV**	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC₅₀s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively .

HY-178267

*p38 MAP* Kinase-IN-2**	p38 MAPK	Cancer
p38 MAP Kinase-IN-2 (Compound 5) is a p38 MAP Kinase inhibitor. p38 MAP Kinase-IN-2 can be used for the research of cancer .

HY-178209

*p38 MAP* Kinase-IN-3**	p38 MAPK	Metabolic Disease
p38 MAP Kinase-IN-3 is a p38 MAP kinase inhibitor (IC₅₀ = 0.09 µM). p38 MAP Kinase-IN-3 can be used for research on metabolic conditions .

HY-E70844

**MAP2K2 Recombinant Human Active Protein Kinase**	MEK	Cancer
MAP2K2 (MEK2) is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. MAP2K2 phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1. MAP2K2 Recombinant Human Active Protein Kinase is a recombinant MAP2K2 protein that can be used to study MAP2K2-related functions .

HY-10441

BMS-626531	p38 MAPK	Cancer
BMS-626531 is a potent and selective p38α MAP kinase inhibitor. BMS-626531 can be used for the research of cancer .

HY-E70843

**MAP2K1 P124L Recombinant Human Active Protein Kinase**	MEK	Cancer
MAP2K1 encodes mitogen-activated protein kinase 1 (MEK1), which is a key component in the RAS-mitogen-activated protein kinase kinase (RAS/MAPK) signal transduction pathway. MAP2K1 P124L mutation is a mild mutation. MAP2K1 P124L Recombinant Human Active Protein Kinase is a recombinant MAP2K1 P124L protein that can be used to study MAP2K1 P124L-related functions .

HY-171275

*p38 MAP* Kinase-IN-1**	p38 MAPK	Inflammation/Immunology
p38 MAP Kinase-IN-1 (Compound 4) is the inhibitor for p38, and can be used for inflammation and auto-immune responses related research .

HY-E70842

**MAP2K1 L115P Recombinant Human Active Protein Kinase**	MEK	Cancer
MAP2K1 (also known as MEK1) is downstream of the RAF family and activation results in ERK1/2 activation. Activating mutations in MAP2K1 have been reported almost exclusively in exons 1 and 2 in both hematologic malignancies. MAP2K1 L115P is a mutant of MAP2K1. MAP2K1 L115P Recombinant Human Active Protein Kinase is a recombinant MAP2K1 L115P protein that can be used to study MAP2K1 L115P-related functions .

HY-175429

p38 MAPK-IN-7	p38 MAPK	Inflammation/Immunology
p38 MAPK-IN-7 (Compound 2) is an orally active, potent and selective p38 MAP kinase inhibitor (IC₅₀=170 nM). p38 MAPK-IN-7 is promising for research of inflammatory diseases such as rheumatoid arthritis and septic shock .

HY-175433

p38 MAPK-IN-10	p38 MAPK	Inflammation/Immunology
p38 MAPK-IN-10 (Compound 4) is an orally active and potent p38 MAP kinase inhibitor (IC₅₀=570 nM). p38 MAPK-IN-10 is promising for research of chronic inflammatory diseases such as rheumatoid arthritis and Crohn’s disease .

HY-122464A

Jasmonic acid (-)-Jasmonic acid	Molecular Glues	Others
Jasmonic acid ((-)-Jasmonic acid) is a plant growth regulator and a derivative of Linolenic acid (HY-N0728). Jasmonic acid signaling can also induce the MAP kinase cascade pathway, calcium channel, and many processes that interact with signaling molecules .

HY-70006A

Galeterone hydrochloride TOK-001 hydrochloride; VN-124-1 hydrochloride	Molecular Glues Androgen Receptor MNK Cytochrome P450 Apoptosis	Cancer
Galeterone (TOK-001) hydrochloride is a potent, orally active molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2. Galeterone hydrochloride also functions as a CYP17 inhibitor (IC₅₀ = 47 nM). Galeterone hydrochloride induces cell apoptosis. Galeterone hydrochloride inhibits tumor growth in human prostate cancer xenograft mouse models. Galeterone hydrochloride can be used for castration resistant prostate cancer (CRPC) and pancreatic ductal adenocarcinoma (PDAC) research ^[1][2].

HY-70006

Galeterone 3 Publications Verification TOK-001; VN-124-1	Molecular Glues Androgen Receptor MNK Cytochrome P450 Apoptosis	Cancer
Galeterone (TOK-001) is a potent, orally active molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2. Galeterone also functions as a CYP17 inhibitor (IC₅₀ = 47 nM). Galeterone induces cell apoptosis. Galeterone inhibits tumor growth in human prostate cancer xenograft mouse models. Galeterone can be used for castration resistant prostate cancer (CRPC) and pancreatic ductal adenocarcinoma (PDAC) research ^[1][2].

HY-18794

R-03201195	p38 MAPK TNF Receptor Interleukin Related	Inflammation/Immunology
R-03201195 is an efficient and selective p38 MAP kinase inhibitor with an IC₅₀ for p38α of 0.7 nM. R-03201195 has inhibitory activity against TNF-α in THP-1 cells and against IL-1β in human whole blood, with IC₅₀ values of 0.25 and 0.57 nM respectively. R-03201195 BIRB-1017 can be used for inflammatory diseases such as rheumatoid arthritis .

HY-77251

TAK1/MAP4K2 inhibitor 1 1 Publications Verification	MAP4K MAP3K	Cancer
TAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, with IC₅₀s of 41.1 nM and 18.2 nM, respectively.

HY-111164

CBS-3595	p38 MAPK Phosphodiesterase (PDE)	Inflammation/Immunology
CBS-3595 is a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 with anti-inflammatory and anti-allodynic activities. CBS-3595 reduces the production of the proinflammatory cytokine IL-6 and increases the levels of the anti-inflammatory cytokine IL-10 in rats. CBS-3595 reduces paw oedema formation in the Complete Freund’s adjuvant (CFA) (HY-153808)-induced arthritis rat model. CBS-3595 is promising for research of autoimmune diseases .

HY-E70747

MEK5 Recombinant Human Active Protein Kinase	MEK	Cancer
MEK5 Recombinant Human Active Protein Kinase is a MAP/ERK kinase. MEK5 is thought to lie in an uncharacterized MAP kinase pathway, because MEK5 does not phosphorylate the ERK/MAP kinase family members ERK1, ERK2, ERK3, JNK/SAPK, or p38/HOG1, nor will Raf-1, c-Mos, or MEKK1 highly phosphorylate it .

HY-125012

MAP4K4-IN-3 1 Publications Verification	MAP4K	Metabolic Disease
MAP4K4-IN-3 (Compound 17) is a potent and selective *MAP4K4* inhibitor with an IC₅₀ of 14.9 nM in kinase assay, an IC₅₀ of 470 nM in cell assay. Antidiabetic agent .

HY-105997

AZD 6703	p38 MAPK	Others
AZD 6703 is a p38α MAP kinase inhibitor with activity in inflammatory diseases.

HY-N12898

(Z)-Tetradec-7-en-1-ol	p38 MAPK	Others
(Z)-Tetradec-7-en-1-ol is an activator for mitogen-activated protein kinase (MAP *kinase*) .

HY-145041

HPK1-IN-15	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-15 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-15 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2018049200A1, compound 50) .

HY-145042

HPK1-IN-16	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-16 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-16 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019051199A1, compound 39) .

HY-145044

HPK1-IN-17	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-17 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-17 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019238067A1, compound 73) .

HY-145045

HPK1-IN-18	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-18 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-18 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2019238067A1, compound 1) .

HY-E70861

SIK1 Recombinant Human Active Protein Kinase	Salt-inducible Kinase (SIK)	Inflammation/Immunology
SIK1 is a MAP4 kinase. The SIK1 MAP4K regulates cell proliferation and cell expansion. SIK1 phosphorylates BIK1 and stabilizes it in a kinase activity-dependent manner. SIK1 Recombinant Human Active Protein Kinase is a recombinant SIK1 protein that can be used to study SIK1-related functions .

HY-143868

HPK1-IN-27	MAP4K	Cancer
HPK1-IN-27 is a potent inhibitor of HPK1. MAP4K1 is also known as hematopoietic progenitor kinase 1 (HPK1). MAP4K1 is a serine/threonine kinase and member of the germinal center kinase family. HPK1-IN-27 has the potential for the research of cancer diseases (extracted from patent WO2019016071A1, compound 38) .

HY-143871

HPK1-IN-30	MAP4K	Cancer
HPK1-IN-30 is a potent inhibitor of HPK1. MAP4K1 is also known as hematopoietic progenitor kinase 1 (HPK1). MAP4K1 is a serine/threonine kinase and member of the germinal center kinase family. HPK1-IN-30 has the potential for the research of cancer diseases (extracted from patent WO2021175271A1, compound 3) .

HY-N2484

Methylnissolin Astrapterocarpan	PDGFR ERK	Cardiovascular Disease
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC₅₀ of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade .

HY-112333

SC-68376	p38 MAPK	Inflammation/Immunology
SC-68376 is a potent, reversible, ATP-competitive, and selective inhibitor of p38 MAP kinase inhibitor .

HY-18861

BIRB-1017	p38 MAPK	Cancer
BIRB-1017 is a potent inhibitor of p38 MAP kinase. BIRB-1017 can be used in inflammation research .

HY-148061

DB1113	PROTACs Bcr-Abl CDK Salt-inducible Kinase (SIK) Cyclin G-associated Kinase (GAK) MAP4K MAPKAPK2 (MK2) Ferroptosis ULK LIM Kinase (LIMK)	Cancer
DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity .

HY-16715

Acumapimod 1 Publications Verification BCT197	p38 MAPK Autophagy	Inflammation/Immunology
Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC₅₀ of less than 1 μM for p38α.

HY-18306

SB 242235 2 Publications Verification	p38 MAPK Autophagy	Cancer
SB-242235 is a potent and selective p38 MAP kinase inhibitor, with an IC₅₀ of 1.0　μM in primary human chondrocytes .

HY-171178

DK2403	p38 MAPK	Cancer
DK2403 (compound 25) is a *MAP2K7* inhibitor (IC₅₀= 0.01 μM). DK2403 can effectively inhibit *MAP2K7* without significantly disrupting the larger kinase group and can be used to study childhood T-cell acute lymphoblastic leukemia .

HY-E70839

KHS1 Recombinant Human Active Protein Kinase	Ser/Thr Kinase	Cancer
MAP4K5 (KHS1) belongs to the mammalian Ste20-like serine/threonine kinase family. MAP4K5 plays an important role in regulating a range of cellular responses and is involved in Wnt signaling in hematopoietic cells. KHS1 Recombinant Human Active Protein Kinase is a recombinant KHS1 protein that can be used to study KHS1-related functions .

HY-19562

PF-06260933 4 Publications Verification	MAP4K	Inflammation/Immunology
PF-06260933 is an orally active and highly selective inhibitor of *MAP4K4* with IC₅₀s of 3.7 and 160 nM for kinase and cell, respectively.

HY-170443

PF-07265028	MAP4K	Cancer
PF-07265028 is a selective hematopoietic progenitor kinase 1 *(HPK1/MAP4K1). PF-07265028 can be used in the research of cancer. PF-07265028 shows very potent cellular activity as measured by pSLP76 IC₅₀* (17 nM) .

HY-145702

MAP855	MEK ERK	Cancer
MAP855 is a highly potent, selective, ATP-competitive and orally active MEK1/2 kinase inhibitor (MEK1 ERK2 cascade IC₅₀=3 nM, pERK EC₅₀=5 nM). MAP855 shows equipotent inhibition of wild-type and mutant MEK1/2 .

HY-177802

C3 sodium	ERK	Cancer
C3 sodium is an aptamer that binds to Erk2. C3 binds to the MAP kinase insert domain, a unique site on Erk1/2. Due to this recognition profile C3 inhibits Erk2 activation by its upstream kinase MKK1.

HY-P3894

*P34cdc2 Kinase* Fragment**	Microtubule/Tubulin Mitosis	Others
P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis. P34cdc2 Kinase can phosphorylate mitogen-activated protein 2 (MAP2) to regulate microtubules polymerization in Xenopus oocytes meiosis .

HY-12358

*Tpl2 Kinase* Inhibitor 1** 1 Publications Verification	MAP3K p38 MAPK MAPKAPK2 (MK2)	Inflammation/Immunology Cancer
Tpl2 Kinase Inhibitor 1 is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC₅₀=50 nM). Tpl2 consists of COT kinase and *MAP3K8. Tpl2 Kinase* Inhibitor 1 plays an important role in the regulation of the inflammatory response and the progression of some cancers .

HY-12358A

*Tpl2 Kinase* Inhibitor 1 hydrochloride**	MAP3K p38 MAPK MAPKAPK2 (MK2)	Inflammation/Immunology Cancer
Tpl2 Kinase Inhibitor 1 hydrochloride is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC₅₀=50 nM). Tpl2 consists of COT kinase and *MAP3K8. Tpl2 Kinase* Inhibitor 1 hydrochloride plays an important role in the regulation of the inflammatory response and the progression of some cancers .

HY-112080A

(R)-BAY-6035	Histone Methyltransferase	Others
(R)-BAY-6035 is a novel inhibitor that selectively targets the methylation of MAP3K2 by SMYD3, demonstrating nanomolar potency and specificity against kinases and other protein lysine methyltransferases.

HY-124152

3,4-Dephostatin Methyl-3,4-dephostatin	MAP3K MAP4K Phosphatase	Neurological Disease
3,4-Dephostatin (Methyl-3,4-dephostatin) is an inhibitor of protein-tyrosine phosphatase (PTPase). 3,4-Dephostatin accelerates nerve growth factor (NGF)-induced neurite formation in PC12h cells. 3,4-Dephostatin sustains the NGF-induced tyrosine phosphorylation of proteins, most prominently that of mitogen-activated protein (MAP) kinase. 3,4-Dephostatin also prolongs epidermal growth factor (EGF)-induced tyrosine phosphorylation and activation of *MAP* kinase .

HY-D2415

BODIPY-FL staurosporine	Fluorescent Dye	Others
BODIPY-FL staurosporine (Compound 8a) is a fluorescence probe based on staurosporine, exhibiting high specificity towards tyrosine kinases (TK) and tyrosine kinase-like (TKL) family kinases. BODIPY-FL staurosporine has the potential to develop binding assays for kinases that are not recommended for use with Kinase Tracer 236, such as PIM3, CDC42BPG, MAP2K7, TXK, and SIK3. BODIPY-FL staurosporine can be a powerful tool for analyzing kinase selectivity in kinase drug discovery .

HY-10578

PD 169316 20+ Cited Publications	p38 MAPK Autophagy Enterovirus	Cancer
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC₅₀ of 89 nM. PD169316 selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. PD169316 shows antiviral activity against Enterovirus71. PD169316 shows antiviral activity against Enterovirus71.

HY-139504

Gamcemetinib CC-99677	MAPKAPK2 (MK2)	Inflammation/Immunology
Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC₅₀=156.3 nM) and cell based assays (EC₅₀=89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1 .

Cat. No.	Product Name

HY-L010

MAPK Compound Library

860 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 860 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

Cat. No.	Product Name	Type

HY-D2415

BODIPY-FL staurosporine

Fluorescent Dyes/Probes

BODIPY-FL staurosporine (Compound 8a) is a fluorescence probe based on staurosporine, exhibiting high specificity towards tyrosine kinases (TK) and tyrosine kinase-like (TKL) family kinases. BODIPY-FL staurosporine has the potential to develop binding assays for kinases that are not recommended for use with Kinase Tracer 236, such as PIM3, CDC42BPG, MAP2K7, TXK, and SIK3. BODIPY-FL staurosporine can be a powerful tool for analyzing kinase selectivity in kinase drug discovery .

Cat. No.	Product Name	Type

HY-143212

18:0-22:6 DG 1-Stearoyl-2-docosahexaenoyl-sn-glycerol	Drug Delivery
18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) is a diacylglycerol that can bind to RasGRP and modulate **MAP kinases** activation .

Cat. No.	Product Name	Target	Research Area

HY-107024

Osteogenic Growth Peptide (10-14) OGP(10-14); Historphin	Src	Others
Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor .

HY-P3894

*P34cdc2 Kinase* Fragment**	Microtubule/Tubulin Mitosis	Others
P34cdc2 Kinase Fragment is associated with the completion of DNA replication in yeast mitosis. P34cdc2 Kinase can phosphorylate mitogen-activated protein 2 (MAP2) to regulate microtubules polymerization in Xenopus oocytes meiosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2484

Methylnissolin Astrapterocarpan	Cardiovascular Disease Monophenols Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Other Flavonoids Disease Research Fields	PDGFR ERK
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC₅₀ of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade .

HY-N7255

Cycloartenol	Microorganisms other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	p38 MAPK Apoptosis
Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development .

HY-N2110

Phellopterin	Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants Inflammation/Immunology Disease Research Fields	Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus .

HY-122464A

Jasmonic acid (-)-Jasmonic acid	Leguminosae Ketones, Aldehydes, Acids Source classification Plants Vicia faba L.	Molecular Glues
Jasmonic acid ((-)-Jasmonic acid) is a plant growth regulator and a derivative of Linolenic acid (HY-N0728). Jasmonic acid signaling can also induce the MAP kinase cascade pathway, calcium channel, and many processes that interact with signaling molecules .

HY-N12898

(Z)-Tetradec-7-en-1-ol	Natural Products Animals Source classification	p38 MAPK
(Z)-Tetradec-7-en-1-ol is an activator for mitogen-activated protein kinase (MAP *kinase*) .

HY-N0811

Anemarsaponin B	Liliaceae Classification of Application Fields Source classification Anemarrhena asphodeloides Bunge Plants Inflammation/Immunology Disease Research Fields Steroids	NO Synthase COX NF-κB MEK
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

HY-N7255R

Cycloartenol (Standard)	Microorganisms other families Source classification Plants Steroids	Reference Standards p38 MAPK Apoptosis
Cycloartenol (Standard) is the analytical standard of Cycloartenol. This product is intended for research and analytical applications. Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development .

HY-N2110R

Phellopterin (Standard)	Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants	Reference Standards Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.

Species:	Human (52) Mouse (3)
Tag:	His (27) Tag Free (14) Strep (1) GST (23) Flag (2)
Source:	Sf9 insect cells (29) P. pastoris (1) E. coli (25)

Cat. No.	Compare	Product Name	Species	Source

HY-P701815

	MKNK2 Protein, Human (His) MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2	Human	E. coli
	MKNK2 is a serine/threonine protein kinase that centrally affects cellular processes by phosphorylating SFPQ/PSF, HNRNPA1, and EIF4E. MKNK2 sits at the intersection of environmental stress and cytokine signaling and regulates translation by enhancing the affinity of EIF4E for the mRNA cap, thereby affecting the translation machinery. MKNK2 Protein, Human (His) is the recombinant human-derived MKNK2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701813

	MKNK1 Protein, Human (sf9, GST) MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1; MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1	Human	Sf9 insect cells
	MKNK1 (MAP Kinase Interacting Serine/Threonine Kinase 1) plays a central role in coordinating cellular responses to environmental stress and cytokines. It exerts regulatory control over translation processes by phosphorylating EIF4E, enhancing its affinity for mRNA cap structures with 7-methylguanosine. This highlights MKNK1's crucial involvement in finely tuning translation machinery in response to diverse cellular stimuli. MKNK1 Protein, Human (sf9, GST) is the recombinant human-derived MKNK1 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P702743

	MAP4K4 Protein, Human (sf9, GST) MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4; FLH21957; hepatocyte progenitor kinase like/germinal center kinase like kinase; HGK; HPK/GCK like kinase; NIK	Human	Sf9 insect cells
	MAP4K4 Protein, Human (sf9, GST) is the recombinant human-derived MAP4K4, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P701678

	ERK1 Protein, Human (GST) MAPK3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1	Human	E. coli
	ERK1 protein is an important serine/threonine kinase in the MAP kinase pathway and cooperates with MAPK1/ERK2 to activate the MAPK/ERK cascade. Stimulated by KIT and KITLG/SCF, this pathway plays a key role in cell growth, adhesion, survival, and differentiation. ERK1 Protein, Human (GST) is the recombinant human-derived ERK1 protein, expressed by E. coli , with N-GST labeled tag.

HY-P702742

	MAP4K1 Protein, Human (sf9) MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1	Human	Sf9 insect cells
	MAP4K1 Protein, Human (sf9) is the recombinant human-derived MAP4K1, expressed by Sf9 insect cells , with tag Free labeled tag. ,

HY-P700592

	MAP2K6 Protein, Human (sf9, His) MAP2K6; mitogen-activated protein kinase kinase 6; MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); EC 2.7.12.2; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPK/ERK kinase 6	Human	Sf9 insect cells
	The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K6 Protein, Human (sf9, His) is the recombinant human-derived MAP2K6 protein, expressed by sf9 insect cells , with N-6*His labeled tag.

HY-P701808

	MARK4 Protein, Human MARK4; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1	Human	E. coli
	MARK4 is a key serine/threonine protein kinase with crucial effects on cellular processes. It phosphorylates microtubule-associated proteins (MAPT/TAU, MAP2, MAP4) and reorganizes the microtubule network. MARK4 Protein, Human is the recombinant human-derived MARK4 protein, expressed by E. coli , with tag free.

HY-P701814

	MKNK2 Protein, Human MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2	Human	E. coli
	MKNK2 is a serine/threonine protein kinase that centrally affects cellular processes by phosphorylating SFPQ/PSF, HNRNPA1, and EIF4E. MKNK2 sits at the intersection of environmental stress and cytokine signaling and regulates translation by enhancing the affinity of EIF4E for the mRNA cap, thereby affecting the translation machinery. MKNK2 Protein, Human is the recombinant human-derived MKNK2 protein, expressed by E. coli , with tag free.

HY-P701809

	MARK4 Protein, Human (His) MARK4; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1	Human	E. coli
	MARK4 is a key serine/threonine protein kinase with crucial effects on cellular processes. It phosphorylates microtubule-associated proteins (MAPT/TAU, MAP2, MAP4) and reorganizes the microtubule network. MARK4 Protein, Human (His) is the recombinant human-derived MARK4 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P75921

	MAP3K8/TPL-2 Protein, Human (sf9, GST) Mitogen-activated protein kinase kinase kinase 8; TPL-2; MAP3K8; COT; ESTF	Human	Sf9 insect cells
	MAP3K8/TPL-2 is critical for LPS-induced, TLR4-mediated activation of MAPK/ERK, leading to TNF production by macrophages. It regulates T cell differentiation, IFNG expression, and host resistance to bacterial infections by negatively regulating type I interferon production. MAP3K8/TPL-2 Protein, Human (sf9, GST) is the recombinant human-derived MAP3K8/TPL-2 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P700593

	MAP3K1 Protein, Mouse (His) MEKK; MEKK1; SRXY6; MEKK 1; MAPKKK1; MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MEK kinase 1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; mitogen-activated protein kinase kinase kinase 1	Mouse	E. coli
	MAP3K1 is a key component of the protein kinase signal transduction cascade and plays a crucial role in cell signaling pathways.Through its kinase activity, MAP3K1 coordinates the activation of the ERK and JNK kinase pathways by phosphorylating MAP2K1 and MAP2K4.MAP3K1 Protein, Mouse (His) is the recombinant mouse-derived MAP3K1 protein, expressed by E.coli , with N-6*His labeled tag.

HY-P701679

	ERK3 Protein, Human (L290V) MAPK6; Mitogen-activated protein kinase 6; MAP kinase 6; MAPK 6; Extracellular signal-regulated kinase 3; ERK-3; MAP kinase isoform p97; p97-MAPK	Human	E. coli
	ERK3 Protein, an atypical MAPK, phosphorylates MAP2 and MAPKAPK5. Interacting with MAPKAPK5, ERK3/MAPK6 undergoes Ser-189 phosphorylation, facilitating MAPKAPK5 activation. Activated MAPKAPK5 reciprocally phosphorylates ERK3/MAPK6. The complex's precise functional implications, especially in cell cycle entry, remain elusive. ERK3 Protein, Human (L290V) is the recombinant human-derived ERK3 protein, expressed by E. coli , with tag free.

HY-P701680

	ERK3 Protein, Human (L290V, His) MAPK6; Mitogen-activated protein kinase 6; MAP kinase 6; MAPK 6; Extracellular signal-regulated kinase 3; ERK-3; MAP kinase isoform p97; p97-MAPK	Human	E. coli
	ERK3 Protein, an atypical MAPK, phosphorylates MAP2 and MAPKAPK5. Interacting with MAPKAPK5, ERK3/MAPK6 undergoes Ser-189 phosphorylation, facilitating MAPKAPK5 activation. Activated MAPKAPK5 reciprocally phosphorylates ERK3/MAPK6. The complex's precise functional implications, especially in cell cycle entry, remain elusive. ERK3 Protein, Human (L290V, His) is the recombinant human-derived ERK3 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701803

	MAPK4 Protein, Human (sf9, His, GST) MAPK4; Mitogen-activated protein kinase 4; MAP kinase 4; MAPK 4; Extracellular signal-regulated kinase 4; ERK-4; MAP kinase isoform p63; p63-MAPK	Human	Sf9 insect cells
	MAPK4, an atypical MAPK protein, phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5, forming a complex with intricate phosphorylation events. Interaction with MAPKAPK5 leads to ERK3/MAPK6 phosphorylation at Ser-189, activating MAPKAPK5, which reciprocally phosphorylates ERK3/MAPK6. The specific cellular role of this interplay, while unclear, suggests ERK3's potential involvement in promoting entry into the cell cycle. MAPK4 Protein, Human (sf9, His, GST) is the recombinant human-derived MAPK4 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

HY-P703250

	MAP4K3 Protein, Human (sf9, GST, Flag) Mitogen-activated protein kinase kinase kinase kinase 3; Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3; MAP4K3; RAB8IPL1; Homo sapiens; Human; GLK; kinase; Serine/threonine-protein kinase; Transferase; 2.7.11.1	Human	Sf9 insect cells
	MAP4K3 Protein, Human (sf9, GST, Flag) is the recombinant human-derived MAP4K3, expressed by sf9 insect cells , with GST, Flag labeled tag. ,

HY-P701791

	JNK3 Protein, Human (His) MAPK10; Mitogen-activated protein kinase 10; MAP kinase 10; MAPK 10; MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3	Human	E. coli
	JNK3 is a critical serine/threonine protein kinase in neuronal processes, regulating proliferation, differentiation, migration, and apoptosis. Activation through MAP2K4/MKK4 and MAP2K7/MKK7 leads to phosphorylation of JNK3, which in turn phosphorylates AP-1 components such as JUN and ATF2, thereby regulating AP-1 transcriptional activity. JNK3 Protein, Human (His) is the recombinant human-derived JNK3 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P74763

	MAPKAPK3 Protein, Human (sf9, GST) MAP kinase-activated protein kinase 3; MAPKAPK-3; MK-3; Chromosome 3p kinase	Human	Sf9 insect cells
	The MAPKAPK3 protein is a stress-activated kinase involved in multiple cellular processes, including cytokine production and endocytosis. It is phosphorylated by p38-alpha/MAPK14 during stress, targets specific substrates, and has similarities to MAPKAPK2 but is less active. MAPKAPK3 Protein, Human (sf9, GST) is the recombinant human-derived MAPKAPK3 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P704002

	ASK3 Protein, Human (Active, sf9, GST) ASK3; MAP3K15; Mitogen-activated protein kinase kinase kinase 15	Human	Sf9 insect cells
	ASK3 Protein, Human (Active, sf9, GST) is the recombinant human-derived ASK3 protein, expressed by Sf9 insect cells, with N-GST tag.

HY-P703924

	p38 gamma/MAPK12 Protein, Human (Active, sf9, GST) Mitogen-activated protein kinase 12; MAP kinase 12; MAPK 12; Extracellular signal-regulated kinase 6 (ERK-6); Mitogen-activated protein kinase p38 gamma (MAP kinase p38 gamma); Stress-activated protein kinase 3	Human	Sf9 insect cells
	The p38 gamma/MAPK12 protein is an important serine/threonine kinase in the MAP kinase pathway and can respond to extracellular stimuli such as pro-inflammatory cytokines or stress. p38 MAPK activates transcription factors such as ELK1 and ATF2, each of which phosphorylates approximately 200 to 300 substrates. p38 gamma/MAPK12 Protein, Human (Active, sf9, GST) is the recombinant human-derived p38 gamma/MAPK12 protein, expressed by Sf9 insect cells, with N-GST labeled tag.

HY-P700589

	MAP2K4 Protein, Human (P. pastoris, His-GST) MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; dual specificity mitogen-activated protein kinase kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; MAP kinase kinase 4; JNK-activated kinase 1; JNK activating kinase 1; JNK-activating kinase 1; c-Jun N-terminal kinase kinase 1; stress-activated protein kinase kinase 1; JNKK; SEK1; MAPKK4; SAPKK1; SAPKK-1;	Human	P. pastoris
	The MAP2K4 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K4 Protein, Human (P. pastoris, His-GST) is the recombinant human-derived MAP2K4 protein, expressed by P. pastoris , with N-6*His, N-GST labeled tag.

HY-P702841

	MAP2K4 Protein, Human (sf9) MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; dual specificity mitogen-activated protein kinase kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; MAP kinase kinase 4; JNK-activated kinase 1; JNK activating kinase 1; JNK-activating kinase 1; c-Jun N-terminal kinase kinase 1; stress-activated protein kinase kinase 1; JNKK; SEK1; MAPKK4; SAPKK1; SAPKK-1	Human	Sf9 insect cells
	The MAP2K4 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K4 Protein, Human (sf9) is the recombinant human-derived MAP2K4 protein, expressed by sf9 insect cells , tag free.

HY-P701790

	JNK3 Protein, Human (364a.a, His) MAPK10; Mitogen-activated protein kinase 10; MAP kinase 10; MAPK 10; MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3	Human	E. coli
	JNK3 is a critical serine/threonine protein kinase in neuronal processes, regulating proliferation, differentiation, migration, and apoptosis. Activation through MAP2K4/MKK4 and MAP2K7/MKK7 leads to phosphorylation of JNK3, which in turn phosphorylates AP-1 components such as JUN and ATF2, thereby regulating AP-1 transcriptional activity. JNK3 Protein, Human is the recombinant human-derived JNK3 protein, expressed by E. coli , with tag free.

HY-P704064

	MAP2K4 Protein, Human (sf9, His, StrepⅡ, GST) Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4 (MEK 4); SAPK/ERK kinase 1 (SEK1); Stress-activated protein kinase kinase 1 (SAPK kinase 1; SAPKK-1; SAPKK1); c-Jun N-terminal kinase kinase 1 (JNKK)	Human	Sf9 insect cells
	The MAP2K4 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K4 Protein, Human (sf9, His, StrepⅡ, GST) is the recombinant human-derived MAP2K4 protein, expressed by Sf9 insect cells, with N-His and N-GST and N-StrepⅡ labeled tag.

HY-P76946

	MAP4K2 Protein, Human (sf9, His-GST) Mitogen-activated protein kinase kinase kinase kinase 2; GC kinase; MEKKK 2; GCK; RAB8IP	Human	Sf9 insect cells
	MAP4K2 is a serine/threonine protein kinase and an important component of the MAP kinase signal transduction pathway. It acts as a MAPK kinase kinase (MAP4K), activating the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) pathway and, to a lesser extent, the p38 MAPKs pathway. MAP4K2 Protein, Human (sf9, His-GST) is the recombinant human-derived MAP4K2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P703054

	ASK3 Protein, Human (588a.a, sf9, GST) ASK3; MAP3K15; Mitogen-activated protein kinase kinase kinase 15;	Human	Sf9 insect cells
	ASK3 Protein, Human (588a.a, sf9, GST) is the recombinant human-derived ASK3, expressed by Sf9 insect cells, with GST labeled tag.

HY-P702735

	MAPK1/ERK2 Protein, Human (Flag, His) MAPK1; mitogen-activated protein kinase 1; PRKM1, PRKM2; ERK; ERK2; MAPK2; p41MAPk; ERK-2; MAPK 2; p42-MAPK; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; protein tyrosine kinase ERK2; mitogen-activated protein kinase 2; extracellular signal-regulated kinase 2; p38; p40; p41; ERT1; PRKM1; PRKM2; P42MAPK	Human	E. coli
	ERK2 Protein, a key component of the MAPK/ERK cascade, regulates diverse cellular processes such as transcription, translation, mitosis, apoptosis, endosomal dynamics, and Golgi apparatus fragmentation. Through phosphorylation, it modulates substrates including transcription factors, cytoskeletal elements, apoptosis regulators, translation regulators, protein kinases, and phosphatases. MAPK1 Protein, Human (Flag, His) is the recombinant human-derived MAPK1, expressed by E. coli, with His, Flag labeled tag.

HY-P704008

	MAPK1/ERK2 Protein, Human (Inactive, GST) MAPK1; mitogen-activated protein kinase 1; PRKM1, PRKM2; ERK; ERK2; MAPK2; p41MAPk; ERK-2; MAPK 2; p42-MAPK; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; protein tyrosine kinase ERK2; mitogen-activated protein kinase 2; extracellular signal-regulated kinase 2; p38; p40; p41; ERT1; PRKM1; PRKM2; P42MAPK	Human	E. coli
	ERK2 Protein, a key component of the MAPK/ERK cascade, regulates diverse cellular processes such as transcription, translation, mitosis, apoptosis, endosomal dynamics, and Golgi apparatus fragmentation. Through phosphorylation, it modulates substrates including transcription factors, cytoskeletal elements, apoptosis regulators, translation regulators, protein kinases, and phosphatases. MAPK1/ERK2 Protein, Human (Inactive, GST) is the recombinant human-derived MAPK1/ERK2 protein, expressed by E. coli, with N-GST labeled tag.

HY-P701764

	RCK Protein, Human (His) MAP3K19; Mitogen-activated protein kinase kinase kinase 19; Regulated in COPD; protein kinase; SPS1/STE20-related protein kinase YSK4	Human	E. coli
	MAP3K19 is a protein kinase involved in intracellular signaling. MAP3K19 can directly activate the ERK and JNK pathways and plays an important role in maintaining the survival of KRAS-mutant lung cancer cells. In addition, MAP3K19 also regulates allergic airway inflammation in patients with asthma by inhibiting airway epithelial responses stimulated by TWEAK, including reduced adhesion factors and production of RANTES, and suppressing allergic airway inflammation in a mouse model of asthma. RCK Protein, Human (His) is the recombinant human-derived RCK protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701730

	P38β Protein, Human (sf9) MAPK11; Mitogen-activated protein kinase 11; MAP kinase 11; MAPK 11; Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2	Human	Sf9 insect cells
	The P38β protein is an important serine/threonine kinase in the MAP kinase pathway that responds to extracellular stimuli, including proinflammatory cytokines and physical stress. As part of the p38 MAPK family, P38β directly activates transcription factors that phosphorylate many proteins, including RPS6KA5/MSK1 and RPS6KA4/MSK2. P38β Protein, Human (sf9) is the recombinant human-derived P38β protein, expressed by sf9 insect cells , with tag free.

HY-P701731

	P38β Protein, Human (sf9, GST) MAPK11; Mitogen-activated protein kinase 11; MAP kinase 11; MAPK 11; Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2	Human	Sf9 insect cells
	The P38β protein is an important serine/threonine kinase in the MAP kinase pathway that responds to extracellular stimuli, including proinflammatory cytokines and physical stress. As part of the p38 MAPK family, P38β directly activates transcription factors that phosphorylate many proteins, including RPS6KA5/MSK1 and RPS6KA4/MSK2. P38β Protein, Human (sf9, GST) is the recombinant human-derived P38β protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P701705

	ASK1 Protein, Human (His) MAP3K5; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5	Human	E. coli
	ASK1 protein is a key serine/threonine kinase in the MAP kinase pathway, coordinating cellular responses to environmental changes and affecting cell fate, differentiation, and survival. ASK1 is a key player in apoptosis and promotes mitochondria-dependent caspase activation. ASK1 Protein, Human (His) is the recombinant human-derived ASK1 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P701804

	MAPKAPK2 Protein, Human MAPKAPK2; MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2	Human	E. coli
	The MAPKAPK2 protein is a stress-activated kinase involved in multiple cellular processes, including cytokine production, endocytosis, cytoskeletal reorganization, cell migration, cell cycle control, chromatin remodeling, DNA damage response, and transcriptional regulation. MAPKAPK2 Protein, Human is the recombinant human-derived MAPKAPK2 protein, expressed by E. coli , with tag free and ΔH217-P237, S216G mutation.

HY-P701801

	MAP4K6 Protein, Human (sf9, GST) MINK1; Misshapen-like kinase 1; GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6	Human	Sf9 insect cells
	MAP4K6 protein is a key serine/threonine kinase that negatively regulates Ras-related Rap2-mediated signaling, affecting neuronal structure and AMPA receptor trafficking. Its importance is underlined by its important role in regulating synaptic density, dendritic complexity, and surface AMPA receptor expression in hippocampal neurons. MAP4K6 Protein, Human (sf9, GST) is the recombinant human-derived MAP4K6 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P74621

	PRAK/MAPKAPK5 Protein, Human (sf9, His-GST) MAP kinase-activated protein kinase 5; MAPKAP-K5; MK5; PRAK	Human	Sf9 insect cells
	PRAK/MAPKAPK5 protein, a serine/threonine kinase, responds to cellular stress and pro-inflammatory cytokines and acts as a tumor suppressor through MAP kinases (including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta) activated by phosphorylation. Initially located in the nucleus, upon activation, it moves to the cytoplasm and phosphorylates the heat shock protein HSP27. PRAK/MAPKAPK5 Protein, Human (sf9, His-GST) is the recombinant human-derived PRAK/MAPKAPK5 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P701805

	MAPKAPK2 Protein, Human (His) MAPKAPK2; MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2	Human	E. coli
	The MAPKAPK2 protein is a stress-activated kinase involved in multiple cellular processes, including cytokine production, endocytosis, cytoskeletal reorganization, cell migration, cell cycle control, chromatin remodeling, DNA damage response, and transcriptional regulation. MAPKAPK2 Protein, Human (His) is the recombinant human-derived MAPKAPK2 protein, expressed by E. coli , with N-6*His labeled tag and ΔH217-P237, S216G mutation.

HY-P702662

	MAPKAPK2 Protein, Human (323a.a) MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2; MAP kinase-activated protein kinase 2; MAPKAP kinase 2; MAPK-activated protein kinase 2; MK2; MK-2; MAPKAP-K2	Human	E. coli
	The MAPKAPK2 protein is a stress-activated kinase involved in multiple cellular processes, including cytokine production, endocytosis, cytoskeletal reorganization, cell migration, cell cycle control, chromatin remodeling, DNA damage response, and transcriptional regulation. MAPKAPK2 Protein, Human (323a.a) is the recombinant human-derived MAPKAPK2, expressed by E. coli, with tag Free labeled tag.

HY-P705421

	JNK1 Protein, Mouse (Active, sf9, GST) MAP kinase 8; MAPK 8; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; MAPk8	Mouse	Sf9 insect cells

HY-P702663

	MAPKAPK3 Protein, Human (Active, sf9, GST) MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3; MAP kinase-activated protein kinase 3; 3pK; 3PK; MAPKAP3; MAPKAP kinase 3; chromosome 3p kinase; MAPK-activated protein kinase 3; MK-3; MAPKAP-K3; MAPKAPK-3	Human	Sf9 insect cells
	The MAPKAPK3 protein is a stress-activated kinase involved in multiple cellular processes, including cytokine production and endocytosis. It is phosphorylated by p38-alpha/MAPK14 during stress, targets specific substrates, and has similarities to MAPKAPK2 but is less active. MAPKAPK3 Protein, Human (Active, sf9, GST) is the recombinant human-derived MAPKAPK3, expressed by Sf9 insect cells, with GST labeled tag.

HY-P77222

	TAOK3 Protein, Human (sf9, His) Serine/threonine-protein kinase TAO3; JNK/SAPK-inhibitory kinase; DPK; JIK; KDS; MAP3K18	Human	Sf9 insect cells
	TAOK3, a kinase, regulates the p38/MAPK14 and MAPK8/JNK cascades. It activates the p38/MAPK14 cascade, particularly in DNA damage-induced G2/M transition, likely through MAP2K3 and MAP2K6 phosphorylation. TAOK3 inhibits basal MAPK8/JNK activity and dampens its response to epidermal growth factor. These functions showcase TAOK3's role in coordinating cellular responses to DNA damage and growth factor signaling. TAOK3 Protein, Human (sf9, His) is the recombinant human-derived TAOK3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P73825

	MEK1 Protein, Mouse (sf9, His-GST) Dual specificity mitogen-activated protein kinase kinase 1; MAPKK 1; MEK 1; MAP2k1	Mouse	Sf9 insect cells
	The MEK1 protein is a dual-specificity kinase that plays a crucial role in the MAP kinase pathway.MEK1 regulates various cellular processes such as growth, adhesion, survival, and differentiation, as well as transcription, metabolism, and cytoskeletal rearrangements.MEK1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived MEK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P74746

	MKK6 Protein, Human (sf9) Dual specificity mitogen-activated protein kinase kinase 6; MAPKK 6; MEK 6; SAPKK3; MAP2K6	Human	Sf9 insect cells
	The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (sf9) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells, with tag free and additional two amino acids (Gly & Pro) at the N-terminus.

HY-P701806

	MARK1 Protein, Human MARK1; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c	Human	E. coli
	MARK1 is an important serine/threonine protein kinase that critically regulates cell polarity and microtubule dynamics. It phosphorylates microtubule-associated proteins (DCX, MAP2, MAP4, MAPT/TAU), causing their dissociation and disassembly. MARK1 Protein, Human is the recombinant human-derived MARK1 protein, expressed by E. coli , with tag free.

HY-P703907

	TAOK3 Protein, Human (sf9, His, GST) Serine/threonine-protein kinase TAO3; JNK/SAPK-inhibitory kinase; DPK; JIK; KDS; MAP3K18	Human	Sf9 insect cells
	TAOK3, a kinase, regulates the p38/MAPK14 and MAPK8/JNK cascades. It activates the p38/MAPK14 cascade, particularly in DNA damage-induced G2/M transition, likely through MAP2K3 and MAP2K6 phosphorylation. TAOK3 inhibits basal MAPK8/JNK activity and dampens its response to epidermal growth factor. These functions showcase TAOK3's role in coordinating cellular responses to DNA damage and growth factor signaling. TAOK3 Protein, Human (sf9, His, GST) is the recombinant human-derived TAOK3 protein, expressed by Sf9 insect cells, with N-His and N-GST labeled tag.

HY-P701807

	MARK1 Protein, Human (His) MARK1; Serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c	Human	E. coli
	MARK1 is an important serine/threonine protein kinase that critically regulates cell polarity and microtubule dynamics. It phosphorylates microtubule-associated proteins (DCX, MAP2, MAP4, MAPT/TAU), causing their dissociation and disassembly. MARK1 Protein, Human (His) is the recombinant human-derived MARK1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P74745

	MKK6 Protein, Human (sf9, His-GST) Dual specificity mitogen-activated protein kinase kinase 6; MAPKK 6; MEK 6; SAPKK3; MAP2K6	Human	Sf9 insect cells
	The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (sf9, His-GST) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P701639

	TAB1 Protein, Human (His) TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1	Human	E. coli
	The TAB1 protein is a key adapter that activates JNK, NF-kappa-B, and proinflammatory cytokines in response to TLR and cytokine stimulation. It binds to MAP3K7/TAK1, inducing autophosphorylation and full activation. TAB1 Protein, Human (His) is the recombinant human-derived TAB1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701640

	TAB1 Protein, Human TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1	Human	E. coli
	The TAB1 protein is a key adapter that activates JNK, NF-kappa-B, and proinflammatory cytokines in response to TLR and cytokine stimulation. It binds to MAP3K7/TAK1, inducing autophosphorylation and full activation. TAB1 Protein, Human is the recombinant human-derived TAB1 protein, expressed by E. coli , with tag free.

HY-P74748

	MKK6 Protein, Human (S207D, T211D, sf9) Dual specificity mitogen-activated protein kinase kinase 6; MAPKK 6; MEK 6; SAPKK3; MAP2K6	Human	Sf9 insect cells
	The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (S207D, T211D, sf9) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells, with tag free.

HY-P701773

	RSK2 Protein, Human RPS6KA3; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2	Human	E. coli
	RSK2 is a kinase downstream of ERK signaling and plays a critical role in mediating mitosis and stress responses. It activates transcription factors (CREB1, ETV1, NR4A1), affecting proliferation, survival and differentiation. RSK2 Protein, Human is the recombinant human-derived RSK2 protein, expressed by E. coli , with tag free.

HY-P701774

	RSK2 Protein, Human (His) RPS6KA3; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2	Human	E. coli
	RSK2 is a kinase downstream of ERK signaling and plays a critical role in mediating mitosis and stress responses. It activates transcription factors (CREB1, ETV1, NR4A1), affecting proliferation, survival and differentiation. RSK2 Protein, Human (His) is the recombinant human-derived RSK2 protein, expressed by E. coli , with N-6*His labeled tag.

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HY-P82888

	MEKK3 Antibody (YA2633) MAP/ERK kinase kinase 3; MAP3K3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3; MEKK3; Mitogen activated protein kinase kinase kinase 3	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	MEKK3 Antibody (YA2633) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEKK3.

HY-P81343

	MAP2K6 Antibody (YA1088) MAP2K6; MEK6; MKK6; PRKMK6; SKK3; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPKK 6; MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3	WB, IP	Human, Rat
	MAP2K6 Antibody (YA1088) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MAP2K6.

HY-P81378

	MAP4K4/NIK Antibody (YA1123) MAP4K4; HGK, KIAA0687, NIK; Mitogen-activated protein kinase kinase kinase kinase 4; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4 (MEK kinase kinase 4; MEKKK 4); Nck-interacting kinase	IHC-P	Human
	MAP4K4/NIK Antibody (YA1123) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAP4K4/NIK.

HY-P85276

	MAP2K6 Antibody (YA4968) MAP2K6; MEK6; MKK6; PRKMK6; SKK3; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPKK 6; MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3	WB, IP	Human, Mouse, Rat
	MAP2K6 Antibody (YA4968) is a Rabbit-derived and non-conjugated recomninant monoclonal antibody, targeting to MAP2K6.

HY-P85200

	MAP4K4/NIK Antibody (YA4892) MAP4K4; HGK; KIAA0687; NIK; Mitogen-activated protein kinase kinase kinase kinase 4; HPK/GCK-like kinase HGK; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Nck-interacting kinase	WB, FC, ELISA	Human, Mouse
	MAP4K4/NIK Antibody (YA4892) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MAP4K4/NIK.

HY-P85835

	ERK2 Antibody (YA5527) MAPK1; ERK2; PRKM1; PRKM2; Mitogen-activated protein kinase 1; MAP kinase 1; MAPK 1; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2	WB, ICC/IF, ELISA	Human, Mouse, Rat
	ERK2 Antibody (YA5527) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ERK2.

HY-P86387

	ERK1/2 Antibody (YA6079) MAPK3; ERK1; PRKM3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ERK1/2 Antibody (YA6079) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERK1/2.

HY-P83395

	MEK5 Antibody (YA3140) MAP2K5; MEK5; MKK5; PRKMK5; Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPKK 5; MAPK/ERK kinase 5; MEK 5	WB, ICC/IF	Human
	MEK5 Antibody (YA3140) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK5.

HY-P83314

	MEK2 Antibody (YA3059) MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse
	MEK2 Antibody (YA3059) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK2.

HY-P85274

	MEK2 Antibody (YA4966) MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2	WB; IHC-P; IHC-F; IF	Human, Mouse, Rat
	MEK2 Antibody (YA4966) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MEK2.

HY-P85739

	MEK2 Antibody (YA5431) MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2	WB	Human, Rat, Mouse
	MEK2 Antibody (YA5431) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MEK2.

HY-P86470

	MEK1 Antibody (YA6162) MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MEK1 Antibody (YA6162) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK1.

HY-P83578

	MEK3+MEK6 Antibody (YA3323) MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; MAP2K6; MEK3; MAP kinase kinase 3; MAPKK3; MAPK/ERK kinase 3	WB, ICC/IF, IP	Human, Mouse
	MEK3+MEK6 Antibody (YA3323) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK3+MEK6.

HY-P86354

	ERK5 Antibody (YA6046) MAPK7; BMK1; ERK5; PRKM7; Mitogen-activated protein kinase 7; MAP kinase 7; MAPK 7; Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ERK5 Antibody (YA6046) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERK5.

HY-P80393

	ERK1/2 Antibody (YA453) 3 Publications Verification MAP kinase 3; MAPK 3; ERK-1; p44-MAPK; MAP kinase 1; MAPK 1; ERK-2; p42-MAPK	WB, ICC/IF, IP, FC	Human, Mouse, Rat
	ERK1/2 Antibody (YA453) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERK1/2.

HY-P86225

	Phospho-Erk 1/2(Thr202/Tyr204) Antibody (YA5917) MAPK3; ERK1; PRKM3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-Erk 1/2(Thr202/Tyr204) Antibody (YA5917) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Erk 1/2(Thr202/Tyr204).

HY-P86457

	MEK-1/2 Antibody (YA6149) MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein k	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MEK-1/2 Antibody (YA6149) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK-1/2.

HY-P85516

	MEK1 Antibody (YA5208) AA589381; Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 1; ERK activator kinase 2; FLJ26075; MAP kinase kinase 1; MAP kinase kinase 2; MAP2K1; MAP2K2; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MAPKK1; MAPKK2; MEK 1; MEKK1; Mitogen activated protein kinase kinase 1; Mitogen activated protein kinase kinase 2; Mitogen-activated protein kinase kinase 2, p45; MK2; MKK 1; MKK 2; MKK1; MKK2; MP2K1_HUMAN; PRKMK 1; PRKMK 2; Prkmk1; Prkmk2; protein kinase, mitogen-activated, kinase 1; MAP kinase kinase 1; Protein kinase, mitogen-activated, kinase 1; Protein kinase, mitogen-activated, kinase 2.	WB	Human
	MEK1 Antibody (YA5208) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MEK1.

HY-P85152

	MAPK6/ERK3 Antibody (YA4844) MAPK6; ERK3; PRKM6; Mitogen-activated protein kinase 6; MAP kinase 6; MAPK 6; Extracellular signal-regulated kinase 3; ERK-3; MAP kinase isoform p97; p97-MAPK	WB, FC, ELISA	Human
	MAPK6/ERK3 Antibody (YA4844) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MAPK6/ERK3.

HY-P86742

	ERK1/2 Antibody (YA6434) ERK; ERK-1; ERT 2; ERT2; Extracellular Signal Regulated kinase 1; Extracellular signal related kinase 1; Extracellular signal-regulated kinase 1; HGNC6877; HS44KDAP; HUMKER1A; Insulin Stimulated MAP2 kinase; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase; MAP kinase isoform p44; MAPK 1; MAPK 3; MAPK; MAPK1; MAPk3; MGC20180; Microtubule Associated Protein 2 kinase; Microtubule-associated protein 2 kinase; Mitogen Activated Protein kinase 3; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 3; MK03_HUMAN; OTTHUMP00000174538; OTTHUMP00000174541; p44 ERK1; p44 MAPK; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM 3; PRKM3; Protein kinase Mitogen Activated 3.	WB, IHC-P, IHC-F, IF-Tissue, FC	Human, Mouse, Rat
	ERK1/2 Antibody (YA6434) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to ERK1/2.

HY-P80832

	Phospho-MEK1 (Ser298) Antibody (YA178) 1 Publications Verification MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1	WB, ICC/IF	Human, Mouse, Rat
	Phospho-MEK1 (Ser298) Antibody (YA178) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-MEK1 (Ser298).

HY-P80833

	Phospho-MEK1 (Thr292) Antibody (YA177) MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1	WB	Mouse, Rat
	Phospho-MEK1 (Thr292) Antibody (YA177) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-MEK1 (Thr292).

HY-P85712

	p38 alpha/MAPK14 Antibody (YA5404) Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Stress-activated protein kinase 2a; SAPK2a;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	p38 alpha/MAPK14 Antibody (YA5404) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p38 alpha/MAPK14.

HY-P86460

	p38 alpha/MAPK14 Antibody (YA6152) Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Stress-activated protein kinase 2a; SAPK2a;	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	p38 alpha/MAPK14 Antibody (YA6152) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p38 alpha/MAPK14.

HY-P83469

	MEK3 Antibody (YA3214) AW212142; dual specificity mitogen activated protein kinase kinase 3; Dual specificity mitogen activated protein kinase kinase 6; Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAP kinase kinase 6; MAP2k3; MAP2K6; MAPK ERK kinase 3; MAPK/ERK kinase 3; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MAPKK3; MAPKK6; MEK 3; MEK 6; MEK3; Mitogen activated protein kinase kinase 3; Mitogen activated protein kinase kinase 6; MKK 3; MKK3; MKK6; mMKK3b; MP2K3_HUMAN; PRKMK 3; PRKMK3; PRKMK6; Protein kinase; mitogen activated; kinase 6 (MAP kinase kinase 6); protein kinase; mitogen-activated; kinase 3; SAPK kinase 2; SAPKK 2; SAPKK 3; SAPKK-2; SAPKK2; SAPKK3; Stress activated protein kinase kinase 2; Stress activated protein kinase kinase 3; Stress-activated protein kinase kinase 2.	WB, ICC/IF, IP	Human, Mouse, Rat
	MEK3 Antibody (YA3214) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK3.

HY-P81156

	phospho-ERK1 + 2 (Thr183/Tyr185) Antibody ERK1 + ERK2 (phospho Thr183/Tyr185); phospho-ERK1/MAPK-1/2(Thr183/Tyr185); ERK 1; ERK 2; ERK-2; ERK1; ERK2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 2; Extracellular signal regulated kinase 2; Extracellular signal-regulated kinase 2; HS44KDAP; HUMKER1A; Insulin stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42;	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse
	phospho-ERK1 + 2 (Thr183/Tyr185) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to phospho-ERK1 + 2 (Thr183/Tyr185).

HY-P82902

	MEK7 Antibody (YA2647) MAP2K7; JNKK2; MEK7; MKK7; PRKMK7; SKK4; Dual specificity mitogen-activated protein kinase kinase 7; MAP kinase kinase 7; MAPKK 7; JNK-activating kinase 2; MAPK/ERK kinase 7; MEK 7; Stress-activated protein kinase kinase 4; SAPK kinase 4; S	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	MEK7 Antibody (YA2647) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK7.

HY-P86356

	MEK3 Antibody (YA6048) MAP2K3; MEK3; MKK3; PRKMK3; SKK2; Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAPKK 3; MAPK/ERK kinase 3; MEK 3; Stress-activated protein kinase kinase 2; SAPK kinase 2; SAPKK-2; SAPKK2	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MEK3 Antibody (YA6048) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK3.

HY-P83405

	JNK3 Antibody (YA3150) Mitogen-activated protein kinase 10; MAP kinase 10; MAPK 10; MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; MAPK10; JNK3; JNK3A; PRKM10; SAPK1B	WB, ICC/IF, FC	Human, Mouse, Rat
	JNK3 Antibody (YA3150) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to JNK3.

HY-P83470

	MEKK2 Antibody (YA3215) MAP3K2; MAPKKK2; MEKK2; Mitogen-activated protein kinase kinase kinase 2; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2	WB, ICC/IF, IP	Human, Mouse, Rat
	MEKK2 Antibody (YA3215) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEKK2.

HY-P85273

	MEKK2 Antibody (YA4965) MAP3K2; MAPKKK2; MEKK2; Mitogen-activated protein kinase kinase kinase 2; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2	WB; IHC-P; IHC-F; ICC/IF; IF; IP; FC	Human, Mouse, Rat
	MEKK2 Antibody (YA4965) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to MEKK2.

HY-P80908

	TAK1 Antibody (YA663) 1 Publications Verification MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1	WB	Human, Mouse, Rat, Monkey
	TAK1 Antibody (YA663) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TAK1.

HY-P86498

	TAK1 Antibody (YA6190) MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	TAK1 Antibody (YA6190) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TAK1.

HY-P85275

	MEK4 Antibody (YA4967) MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated pro	WB, IHC, FC, ELISA	Human
	MEK4 Antibody (YA4967) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MEK4.

HY-P86344

	MEK4 Antibody (YA6036) MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated pro	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MEK4 Antibody (YA6036) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK4.

HY-P85237

	JNK3 Antibody (YA4929) MAPK10; JNK3; JNK3A; PRKM10; SAPK1B; Mitogen-activated protein kinase 10; MAP kinase 10; MAPK 10; MAP kinase p49 3F12; Stress-activated protein kinase 1b; SAPK1b; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3	WB; ICC/IF; FC	Human, Mouse, Rat
	JNK3 Antibody (YA4929) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to JNK3.

HY-P83325

	*MAPKAP Kinase* 3 Antibody (YA3070)** MAPKAPK3; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP-K3; MAPKAPK-3; MK-3; Chromosome 3p kinase; 3pK	WB, IP	Human
	MAPKAP Kinase 3 Antibody (YA3070) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAPKAP Kinase 3.

HY-P86156

	MAPKAPK2 Antibody (YA5848) MAPKAPK2; MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MAPKAPK2 Antibody (YA5848) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAPKAPK2.

HY-P80858

	Phospho-TAK1 (Ser439) Antibody (YA144) 1 Publications Verification MAP3K7; TAK1; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1	WB, ICC/IF, IP	Human, Mouse, Rat
	Phospho-TAK1 (Ser439) Antibody (YA144) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-TAK1 (Ser439).

HY-P80834

	Phospho-MEK4 (Ser80) Antibody (YA176) MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated pro	WB, IP	Human
	Phospho-MEK4 (Ser80) Antibody (YA176) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-MEK4 (Ser80).

HY-P80214

	MAPKAPK2 Antibody (YA304) MAP kinase activated protein kinase 2 antibody; MAP kinase-activated protein kinase 2 antibody; MAPK activated protein kinase 2 antibody; MAPK-activated protein kinase 2 antibody; MAPK2_HUMAN antibody; MAPKAP K2 antibody; MAPKAP kinase 2 antibody; MAPKAPK 2 antibody; MAPKAPK-2 antibody; MAPKAPK2 antibody; Mitogen activated protein kinase activated protein kinase 2 antibody; MK 2 antibody; MK2 antibody	WB, IP	Human, Mouse, Rat
	MAPKAPK2 Antibody (YA304) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MAPKAPK2.

HY-P80549

	ASK1 Antibody MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5	WB, IHC-P, ICC/IF, FC	Human, Mouse
	ASK1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to ASK1.

HY-P85311

	p38β Antibody (YA5003) MAPK11; PRKM11; SAPK2; SAPK2B; Mitogen-activated protein kinase 11; MAP kinase 11; MAPK 11; Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2	WB, ELISA	Human
	p38β Antibody (YA5003) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to p38β.

HY-P83774

	Phospho-MAPKAPK2 (Thr334) Antibody MAPKAPK2; MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Phospho-MAPKAPK2 (Thr334) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-MAPKAPK2 (Thr334).

HY-P85046

	ASK1 Antibody (YA4738) MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5	WB, IHC-P, ICC/IF, FC, ELISA	Human
	ASK1 Antibody (YA4738) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ASK1.

HY-P86322

	ASK1 Antibody (YA6014) MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse
	ASK1 Antibody (YA6014) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ASK1.

HY-P80792

	Phospho-ASK1 (Ser966) Antibody MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5	WB, IHC-P	Human, Mouse, Rat
	Phospho-ASK1 (Ser966) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-ASK1 (Ser966).

HY-P83492

	MLK3 Antibody (YA3237) MAP3K11; MLK3; PTK1; SPRK; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase	WB, ICC/IF	Human
	MLK3 Antibody (YA3237) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MLK3.

HY-P85471

	TAB1 Antibody (YA5163) TAB1; MAP3K7IP1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1	WB	Human, Mouse, Rat, Bovine, Dog, Pig
	TAB1 Antibody (YA5163) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to TAB1.

HY-P85333

	MAPKAPK5 Antibody (YA5025) MAPKAPK5; PRAK; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; p38-regulated/activated protein kinase; PRAK	IHC, ELISA	Human
	MAPKAPK5 Antibody (YA5025) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MAPKAPK5.

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Cat. No.	Product Name		Classification

HY-143212

18:0-22:6 DG 1-Stearoyl-2-docosahexaenoyl-sn-glycerol		Phospholipids
18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) is a diacylglycerol that can bind to RasGRP and modulate **MAP kinases** activation .

HY-177802

C3 sodium		Aptamers
C3 sodium is an aptamer that binds to Erk2. C3 binds to the MAP kinase insert domain, a unique site on Erk1/2. Due to this recognition profile C3 inhibits Erk2 activation by its upstream kinase MKK1.

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MAP kinase

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