2. Search Result
Search Result
Results for "

C9orf72

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

2

Antibodies

6

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-132581A
    Tadnersen sodium
    1 Publications Verification

    BIIB078 sodium; IONIS-C9Rx sodium

    		 Others Ras Neurological Disease
    Tadnersen sodium, an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion .
    Tadnersen sodium
  • HY-132581
    Tadnersen
    1 Publications Verification

    BIIB078; IONIS-C9Rx

    		 Ras Others Neurological Disease
    Tadnersen (BIIB078), an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion .
    Tadnersen
  • HY-153898
    rTRD01

    		Amyloid-β Neurological Disease
    rTRD01 is a TDP-43 ligand that binds to TDP-43’s RRM1 and RRM2 domains (Kd=89 uM for TDP-43102–269). rTRD01 partially disrupts TDP-43’s interaction with the hexanucleotide RNA repeat of the disease-linked c9orf72 gene. rTRD01 can be used for the research of neurodegenerative diseases .
    rTRD01
  • HY-RS21991
    C9orf72 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    C9orf72 Mouse Pre-designed siRNA Set A contains three designed siRNAs for C9orf72 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    C9orf72 Mouse Pre-designed siRNA Set A
    C9orf72 Mouse Pre-designed siRNA Set A
  • HY-RS01760
    C9orf72 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    C9orf72 Human Pre-designed siRNA Set A contains three designed siRNAs for C9orf72 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    C9orf72 Human Pre-designed siRNA Set A
    C9orf72 Human Pre-designed siRNA Set A
  • HY-132581E
    Scrambled Tadnersen

    Scrambled BIIB078; Scrambled IONIS-C9Rx

    		 Ras Neurological Disease
    Scrambled Tadnersen is the Negative Control of Tadnersen sodium (HY-132581A). Tadnersen sodium, an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion .
    Scrambled Tadnersen
  • HY-132581C
    Scrambled Tadnersen sodium

    Scrambled BIIB078 sodium; Scrambled IONIS-C9Rx sodium

    		 Ras Neurological Disease
    Scrambled Tadnersen sodium is the Negative Control of Tadnersen sodium (HY-132581A). Tadnersen sodium, an antisense oligonucleotide (ASO), selectively targets C9ORF72 transcript variants 1 and 3 that carry the expansion .
    Scrambled Tadnersen sodium
  • HY-172902
    RNA binder 1

    		DNA/RNA Synthesis Neurological Disease
    RNA binder 1 (Compound 4b) is a blood-brain permeable RNA binder. RNA binder 1 can selectively bind to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. RNA binder 1 significantly reduces the levels of toxic polypeptides poly(GA) and poly(GP) produced by the G4C2 repeat sequence in amyotrophic lateral sclerosis (ALS) patient-derived cells. RNA binder 1 has no significant effect on the antisense polypeptide poly(PR), showing selectivity for sense RNA. RNA binder 1 can be used in the study of ALS and frontotemporal dementia (FTD) .
    RNA binder 1
  • HY-141878
    di-Ellipticine-RIBOTAC

    		PROTACs Neurological Disease
    Di-Ellipticine-RIBOTAC (Compound 7) is a RNA RIBOTAC degrader, capable of specifically binding and degrading r(G4C2)exp. Di-Ellipticine-RIBOTAC only cuts the expanded GGGGCC repeat RNA in the pathogenic factor of amyotrophic lateral sclerosis/ frontotemporal dementia (c9ALS/FTD) - the chromosome 9 open reading frame 72 (9orf72) gene (r(G4C2)exp), and has no effect on normal short repetitive sequences. Di-Ellipticine-RIBOTAC significantly improves the pathological phenotype of c9ALS/FTD in cells and mouse models. Di-Ellipticine-RIBOTAC can be used for the study of c9ALS/FTD .
    di-Ellipticine-RIBOTAC
  • HY-141878A
    di-Ellipticine-RIBOTAC TFA

    		PROTACs Neurological Disease
    Di-Ellipticine-RIBOTAC TFA (Compound 7) is a RNA RIBOTAC degrader, capable of specifically binding and degrading r(G4C2)exp. Di-Ellipticine-RIBOTAC TFA only cuts the expanded GGGGCC repeat RNA in the pathogenic factor of amyotrophic lateral sclerosis/ frontotemporal dementia (c9ALS/FTD) - the chromosome 9 open reading frame 72 (9orf72) gene (r(G4C2)exp), and has no effect on normal short repetitive sequences. Di-Ellipticine-RIBOTAC TFA significantly improves the pathological phenotype of c9ALS/FTD in cells and mouse models. Di-Ellipticine-RIBOTAC TFA can be used for the study of c9ALS/FTD .
    di-Ellipticine-RIBOTAC TFA

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: