2. GPCR/G Protein
  3. Taste Receptor
  4. S7958

S7958 is a selective and orally active antagonist of the TAS2R8 bitter taste receptor, with its IC50 being 0.06 μM. S7958 only has a weak inhibitory effect on TASR8 and TAS2R39, and has no significant impact on other receptors. S7958 significantly inhibits the perception of bitterness caused by substances such as coffee and drug active ingredients (API) by selectively antagonizing the human bitter taste receptor TAS2R8. S7958 can be used in the medical field to improve the research on the bitterness of oral preparations.

For research use only. We do not sell to patients.

S7958

S7958 Chemical Structure

CAS No. : 1217341-48-4

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Description

S7958 is a selective and orally active antagonist of the TAS2R8 bitter taste receptor, with its IC50 being 0.06 μM. S7958 only has a weak inhibitory effect on TASR8 and TAS2R39, and has no significant impact on other receptors. S7958 significantly inhibits the perception of bitterness caused by substances such as coffee and drug active ingredients (API) by selectively antagonizing the human bitter taste receptor TAS2R8. S7958 can be used in the medical field to improve the research on the bitterness of oral preparations[1].

Molecular Weight

409.44

Formula

C21H23N5O4
CAS No.
SMILES

O=C1N(C(C(C)(C)N1CC2=CC(O)=CC=C2)=O)C3=CN(CC4=C(C)ON=C4C)N=C3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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S7958 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S79581217341-48-4S 7958S-7958Taste Receptorbitterness maskingstructure-activity relationshiphydantoin derivativessensory evaluationInhibitorinhibitorinhibit

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