2. Metabolic Enzyme/Protease Anti-infection
  3. Phosphatase Bacterial
  4. RWJ-60475

RWJ-60475 is a cell-permeable tyrosine phosphatase inhibitor. By inhibiting the activity of CD45/CD148 phosphatase, RWJ-60475 interferes with the phagocytic function of macrophages, thereby blocking the invasion of Legionella pneumophila into host cells and the transport of effector proteins. RWJ-60475 significantly reduces the uptake of bacterial particles by macrophages. RWJ-60475 can be used in the research of anti-infection targeting host factors.

For research use only. We do not sell to patients.

RWJ-60475

RWJ-60475 Chemical Structure

CAS No. : 204130-08-5

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Description

RWJ-60475 is a cell-permeable tyrosine phosphatase inhibitor. By inhibiting the activity of CD45/CD148 phosphatase, RWJ-60475 interferes with the phagocytic function of macrophages, thereby blocking the invasion of Legionella pneumophila into host cells and the transport of effector proteins. RWJ-60475 significantly reduces the uptake of bacterial particles by macrophages. RWJ-60475 can be used in the research of anti-infection targeting host factors[1].

Molecular Weight

404.11

Formula

C13H11BrNO7P
CAS No.
SMILES

OP(O)(C(C1=CC([N+]([O-])=O)=CC=C1OC2=CC=C(Br)C=C2)O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RWJ-60475 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RWJ-60475204130-08-5RWJ60475RWJ 60475PhosphataseBacterialCD45 tyrosine phosphatase inhibitorLegionella pneumophilaIcm/Dot secretion systemeffector translocationphagocytosis inhibitionhost-pathogen interactionInhibitorinhibitorinhibit

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