2. GPCR/G Protein
  3. Bombesin Receptor
  4. MK-7725

MK-7725 is a selective, orally active, and blood-brain barrier-permeable agonist of the subtype 3 of the frog skin peptide receptor (BRS-3) with EC50 values for human and mouse BRS-3 of 3 nM and 22-33 nM, respectively. MK-7725 has high binding activity with human BRS-3, with an IC50 of 1.4 nM. MK-7725 significantly reduces the body weight of obese rats and obese dogs. MK-7725 can be used for the treatment of obesity.

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MK-7725

MK-7725 Chemical Structure

CAS No. : 1034152-93-6

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Description

MK-7725 is a selective, orally active, and blood-brain barrier-permeable agonist of the subtype 3 of the frog skin peptide receptor (BRS-3) with EC50 values for human and mouse BRS-3 of 3 nM and 22-33 nM, respectively. MK-7725 has high binding activity with human BRS-3, with an IC50 of 1.4 nM. MK-7725 significantly reduces the body weight of obese rats and obese dogs. MK-7725 can be used for the treatment of obesity[1].

Molecular Weight

615.50

Formula

C25H19F6N5O5S
CAS No.
SMILES

O=S(N1C2=C(C3=NOC(C(C)(O)C)=N3)C=CC=C2NC4=NC(C(F)(F)F)=CC=C4C1)(C5=CC=C(OC(F)(F)F)C=C5)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MK-7725 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-77251034152-93-6MK7725MK 7725Bombesin ReceptorBRS-3 agonistobesitybenzodiazepine sulfonamidepharmacokineticsFAST PD assayweight lossPXR activationInhibitorinhibitorinhibit

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