2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. MD5

MD5 is a selective TMPRSS6 mimetic peptide inhibitor with an IC50 for recombinant human TMPRSS6 protein of 22 nM and a Ki of 3.4 nM. MD5 exhibits the significantly reduced inhibitory effect on Matriptase, with an IC50 of 352 nM and a Ki of 99.2 nM. MD5 exhibits good target specificity and only has a weak inhibitory effect on thrombin (Thrombin), with Ki of 120 nM. MD5 demonstrates good initial drugability and can be used for the study of iron overload diseases (such as hereditary hemochromatosis, β-thalassemia).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MD5

MD5 Chemical Structure

CAS No. : 3051556-89-6

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MD5 Related Antibodies

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Description

MD5 is a selective TMPRSS6 mimetic peptide inhibitor with an IC50 for recombinant human TMPRSS6 protein of 22 nM and a Ki of 3.4 nM. MD5 exhibits the significantly reduced inhibitory effect on Matriptase, with an IC50 of 352 nM and a Ki of 99.2 nM. MD5 exhibits good target specificity and only has a weak inhibitory effect on thrombin (Thrombin), with Ki of 120 nM. MD5 demonstrates good initial drugability and can be used for the study of iron overload diseases (such as hereditary hemochromatosis, β-thalassemia)[1].
Molecular Weight

716.92

Formula

C36H44N8O4S2
CAS No.
Sequence

Phe{H}-Ala{Thiazolyl}-{Chg}-Arg{Kbt}
Sequence Shortening

Phe{H}-Ala{Thiazolyl}-{Chg}-Arg{Kbt}
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MD5 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MD53051556-89-6MD 5MD-5Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesTMPRSS6 inhibitorSubtype selectivityS2 subpocketPeptidomimeticKetobenzothiazole (Kbt)Cyclohexylglycine (Chg)Rational drug designIron overloadHepcidin modulationInhibitorinhibitorinhibit

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