Lactate shuttle between cytotrophoblast and syncytiotrophoblast in the placenta enhances ferroptosis resistance and maintains placental homeostasis: implications for early pregnancy loss

Affiliations

• 1 State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
• 2 University of Chinese Academy of Sciences, Beijing, 101408, China.
• 3 Beijing Institute of Stem Cell and Regenerative Medicine, Beijing, 100101, China.
• 4 NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, Shanghai, 200433, China.
• 5 Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China. mddoctor@163.com.
• 6 State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. shaoxuan@ioz.ac.cn.
• 7 Beijing Institute of Stem Cell and Regenerative Medicine, Beijing, 100101, China. shaoxuan@ioz.ac.cn.
• 8 University of Chinese Academy of Sciences, Beijing, 101408, China. shaoxuan@ioz.ac.cn.
• 9 State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. wangyl@ioz.ac.cn.
• 10 Beijing Institute of Stem Cell and Regenerative Medicine, Beijing, 100101, China. wangyl@ioz.ac.cn.
• 11 University of Chinese Academy of Sciences, Beijing, 101408, China. wangyl@ioz.ac.cn.
• # Contributed equally.