2. Academic Validation
  3. Discovery of Three New Phytotoxins from the Fungus Aspergillus nidulans by Pathway Inactivation

Discovery of Three New Phytotoxins from the Fungus Aspergillus nidulans by Pathway Inactivation

  • Molecules. 2019 Jan 31;24(3):515. doi: 10.3390/molecules24030515.
Lijuan Liao 1,  Xiaolei Zhang 2,  Yi Lou 3,  Chengzeng Zhou 4,  Qianqian Yuan 5,  Jiangtao Gao 6
Affiliations

Affiliations

  • 1 College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. liao_0909@fafu.edu.cn.
  • 2 College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. 2170517007@fafu.edu.cn.
  • 3 College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. louyi032@fafu.edu.cn.
  • 4 College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. 1170516008@m.fafu.edu.cn.
  • 5 College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. 3170515037@m.fafu.edu.cn.
  • 6 College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. jgaotao@fafu.edu.cn.
PMID: 30708999 DOI: 10.3390/molecules24030515
Abstract

Fungi are a source of novel phytotoxic compounds to be explored in the search for effective and environmentally safe herbicides. The genetic inactivation of the biosynthetic pathway of the new phytotoxin cichorine has led to the isolation of three novel phytotoxins from the fungus Aspergillus nidulans: 8-methoxycichorine (4), 8-epi-methoxycichorine (5), and N-(4'-carboxybutyl) cichorine (6). The structure of the new compounds was clearly determined by a combination of nuclear magnetic resonance (NMR) analysis and high-resolution electrospray ionization (HRESIMS). The phytotoxic bioassay was studied on leaves from Zea mays and Medicago polymorpha L. at the concentration of 5 × 10-3 M by using a moist chamber technique. Novel phytotoxins 8-methoxycichorine (4), 8-epi-methoxycichorine (5), and N-(4'-carboxybutyl) cichorine (6) exhibited a better phytotoxic effect than cichorine.

Keywords

Aspergillus nidulans; pathway inactivation; phytotoxic assay; phytotoxins.

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