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  3. Treatment of experimental Salmonella typhimurium infection in mice with lomefloxacin

Treatment of experimental Salmonella typhimurium infection in mice with lomefloxacin

  • J Antimicrob Chemother. 1990 Apr;25(4):629-34. doi: 10.1093/jac/25.4.629.
T Butler 1,  M Cartagenova,  D Dunn
Affiliations

Affiliation

  • 1 Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock 79430.
PMID: 2190972 DOI: 10.1093/jac/25.4.629
Abstract

To evaluate the difluorinated Quinolone lomefloxacin in murine typhoid, mice were inoculated intraperitoneally with the LT-2 strain of Salmonella typhimurium and treated with graded doses of the drug given once daily by an orogastric needle. Treatment with lomefloxacin for seven days reduced mortality with a 50% effective dose of 2.5-7.8 mg/kg/day. When given once daily for three days, doses greater than or equal to 5 mg lomefloxacin/kg/day caused significant reductions in splenic counts of S. typhimurium and prevented the inflammatory response to Infection in the spleen.

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