2. Academic Validation
  3. Total synthesis of amidepsine B and revision of its absolute configuration

Total synthesis of amidepsine B and revision of its absolute configuration

  • J Antibiot (Tokyo). 2009 Feb;62(2):69-74. doi: 10.1038/ja.2008.12.
Tohru Nagamitsu 1,  Kaori Marumoto,  Asami Nagayasu,  Takeo Fukuda,  Shiho Arima,  Ryuji Uchida,  Taichi Ohshiro,  Yoshihiro Harigaya,  Hiroshi Tomoda,  Satoshi Omura
Affiliations

Affiliation

  • 1 School of Pharmacy, Kitasato University, Minato-ku, Tokyo, Japan.
PMID: 19198634 DOI: 10.1038/ja.2008.12
Abstract

The total synthesis of (-)-amidepsine B, a potent diacylglycerol Acyltransferase Inhibitor, has been achieved. This synthetic study resulted in the revision of the previously assigned stereostructure of the natural amidepsine B and determined the absolute configuration.

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