2. Academic Validation
  3. Novel lopinavir analogues incorporating heterocyclic replacements of six-member cyclic urea--synthesis and structure-activity relationships

Novel lopinavir analogues incorporating heterocyclic replacements of six-member cyclic urea--synthesis and structure-activity relationships

  • Bioorg Med Chem Lett. 2004 May 17;14(10):2643-5. doi: 10.1016/j.bmcl.2004.02.089.
Hing L Sham 1,  David A Betebenner,  William Rosenbrook,  Thomas Herrin,  Ayda Saldivar,  Sudthida Vasavanonda,  Jacob J Plattner,  Daniel W Norbeck
Affiliations

Affiliation

  • 1 Pharmaceutical Discovery, R4MA Building AP-10, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. hing.l.sham@abbott.com
PMID: 15109669 DOI: 10.1016/j.bmcl.2004.02.089
Abstract

The HIV Protease Inhibitor ABT-378 (lopinavir) has a six-member cyclic urea in the P-2 position. A series of analogues in which the six-member cyclic urea is replaced by various heterocycles was synthesized and the structure-activity relationships explored.

Figures