2. Academic Validation
  3. Novel lopinavir analogues incorporating non-Aromatic P-1 side chains--synthesis and structure--activity relationships

Novel lopinavir analogues incorporating non-Aromatic P-1 side chains--synthesis and structure--activity relationships

  • Bioorg Med Chem Lett. 2002 Nov 4;12(21):3101-3. doi: 10.1016/s0960-894x(02)00643-1.
Hing L Sham 1,  Chen Zhao,  Leping Li,  David A Betebenner,  Ayda Saldivar,  Sudthida Vasavanonda,  Dale J Kempf,  Jacob J Plattner,  Daniel W Norbeck
Affiliations

Affiliation

  • 1 Pharmaceutical Discovery, R47B, Building AP-10, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. hing.l.sham@abbott.com
PMID: 12372511 DOI: 10.1016/s0960-894x(02)00643-1
Abstract

The HIV Protease Inhibitor Lopinavir has a pseudosymmetric core unit incorporating benzyl groups at both P-1, P-1' positions. A series of analogues incorporating non-aromatic side chains at the P-1 position were synthesized and the structure-activity relationships explored.

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