2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. L-733060

L-733060 is a selective neurokinin-1 (NK-1) receptor antagonist. L-733060 mainly regulates pain transmission and neural plasticity by blocking the binding of Substance P (P substance) to the NK-1 receptor. L-733060 blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus. L-733060 reverses the orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. L-733060 can be used for the study of chronic orofacial pain.

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L-733060

L-733060 Chemical Structure

CAS No. : 148700-85-0

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L-733060 Related Antibodies

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Description

L-733060 is a selective neurokinin-1 (NK-1) receptor antagonist. L-733060 mainly regulates pain transmission and neural plasticity by blocking the binding of Substance P (P substance) to the NK-1 receptor. L-733060 blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus. L-733060 reverses the orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. L-733060 can be used for the study of chronic orofacial pain[1][2].

IC50 & Target[1][2]

NK1R

 

Molecular Weight

403.36

Formula

C20H19F6NO
CAS No.
SMILES

FC(C1=CC(C(F)(F)F)=CC(CO[C@@H]2[C@H](C3=CC=CC=C3)NCCC2)=C1)(F)F
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Purity & Documentation
References
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L-733060 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-733060148700-85-0L733060L 733060Neurokinin ReceptorNK receptorTachykinin receptorNK-1 receptor antagonistorofacial hyperalgesiarostral ventromedial medulladescending pain modulationchronic pain maintenanceInhibitorinhibitorinhibit

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