2. Anti-infection Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Stem Cell/Wnt MAPK/ERK Pathway
  3. Bacterial NO Synthase Interleukin Related Reactive Oxygen Species (ROS) Toll-like Receptor (TLR) ERK JNK p38 MAPK
  4. HVF18-a3-d

HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

HVF18-a3-d

HVF18-a3-d Chemical Structure

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HVF18-a3-d Related Antibodies

Top Publications Citing Use of Products

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nNOS iNOS eNOS

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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ERK ERK1 ERK2 ERK5 ERK8

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JNK1 JNK2 JNK3 JNK

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects[1].

IC50 & Target[1]

IL-6

 

TLR4

 

Molecular Weight

2241.85

Formula

C111H185N31O18
Sequence

d-{Gly-Val-Phe-Arg-Leu-Lys-Lys-Trp-Leu-Lys-Lys-Val-Leu-Lys-Lys-Trp-Gly-Lys-NH2}
Sequence Shortening

d-{GVFRLKKWLKKVLKKWGK-NH2}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HVF18-a3-d Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HVF18-a3-dBacterialNO SynthaseInterleukin RelatedReactive Oxygen Species (ROS)Toll-like Receptor (TLR)ERKJNKp38 MAPKNitric oxide synthasesNOSILExtracellular signal regulated kinasesc-Jun N-terminal kinaseantimicrobialanti-inflammatory and antioxidantInhibitorinhibitorinhibit

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