2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Apoptosis
  3. IGF-1R Insulin Receptor Akt Apoptosis
  4. GTx-134

GTx-134 is a dual insulin-like growth factor 1 receptor/insulin receptor (IGF-1R/IR) inhibitor with an IC50 values for IGF-1R and IR of 97 and 187 nM respectively. GTx-134 inhibits the autophosphorylation of IGF-1R and its downstream signaling pathway (Akt), thereby blocking the proliferation and survival signals of tumor cells. GTx-134 has broad-spectrum inhibitory activity against multiple myeloma cell lines and can induce apoptosis in sensitive cells. GTx-134 significantly inhibits tumor growth in mice with MM1.S cell transplantation. GTx-134 works in synergy with existing therapies (such as protease preparations, immunomodulators). GTx-134 can be used in high-risk myeloma research.

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GTx-134

GTx-134 Chemical Structure

CAS No. : 1008448-19-8

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GTx-134 Related Antibodies

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Description

GTx-134 is a dual insulin-like growth factor 1 receptor/insulin receptor (IGF-1R/IR) inhibitor with an IC50 values for IGF-1R and IR of 97 and 187 nM respectively. GTx-134 inhibits the autophosphorylation of IGF-1R and its downstream signaling pathway (Akt), thereby blocking the proliferation and survival signals of tumor cells. GTx-134 has broad-spectrum inhibitory activity against multiple myeloma cell lines and can induce apoptosis in sensitive cells. GTx-134 significantly inhibits tumor growth in mice with MM1.S cell transplantation. GTx-134 works in synergy with existing therapies (such as protease preparations, immunomodulators). GTx-134 can be used in high-risk myeloma research[1].

Molecular Weight

648.77

Formula

C33H40N6O6S
CAS No.
SMILES

CC(C=C(C=C1)C)=C1OC[C@H](O)CNC2=C(C(NC=C2)=O)C3=NC(C=C4C(C(N(C5CCN(CC5)CCS(C)(=O)=O)C4)=O)=C6)=C6N3
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GTx-134 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GTx-1341008448-19-8GTx134GTx 134IGF-1RInsulin ReceptorAktApoptosisInsulin-like growth factor-1 receptorPKBProtein kinase BIGF-1R inhibitormultiple myelomaPI3K/Akt pathwaycombination therapyxenograft modelInhibitorinhibitorinhibit

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