Foxo1 - forkhead box O1 Gene

Rattus norvegicus

Also known as Fkhr; Foxo1a

Gene ID: 84482 | Gene type: protein coding

About Foxo1

Summary

Enables DNA-binding transcription factor activity; sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; enamel mineralization; and regulation of transcription, DNA-templated. Located in cytosol and nucleus. Used to study non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1). [provided by Alliance of Genome Resources, Apr 2022]

Foxo1 Products(1)

mRNA	Protein	Name
NM_001191846.3	NP_001178775.1	forkhead box protein O1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10960473	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17916612	RGD
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	19273580	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	19443572	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	22417654	RGD
involved in enamel mineralization	IEP IEP: Inferred from expression pattern	25183529	RGD
involved in negative regulation of cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	26436652	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17916612	RGD
involved in positive regulation of smooth muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19483080	RGD
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10960473	RGD
involved in regulation of transcription initiation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19483080	RGD
involved in response to fluoride	IEP IEP: Inferred from expression pattern	25183529	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	20501667	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19483080	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein O1

Forkhead box protein O1A	Forkhead in rhabdomyosarcoma
forkhead box O1A (rhabdomyosarcoma)

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2440	Gypenoside A	Activator	99.42%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxo1	NCBI	NCBI:2308

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