Rcan1 - regulator of calcineurin 1 Gene

Mus musculus

Also known as CSP1; DSC1; RCN1; Dscr1; MCIP1; CALP1L; Adapt78

Gene ID: 54720 | Gene type: protein coding

About Rcan1

Summary

Predicted to enable calcium-dependent protein serine/threonine Phosphatase regulator activity and identical protein binding activity. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; response to ischemia; and short-term memory. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human RCAN1 (regulator of Calcineurin 1). [provided by Alliance of Genome Resources, Apr 2022]

Rcan1 Products(2)

mRNA	Protein	Name
NM_001081549.2	NP_001075018.1	calcipressin-1 isoform 1
NM_019466.4	NP_062339.2	calcipressin-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12809556	MGI
enables protein phosphatase inhibitor activity	IDA IDA: Inferred from direct assay	16024798	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcineurin-NFAT signaling cascade	IGI IGI: Inferred from genetic interaction	16648267	MGI
acts upstream of or within calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	16648267	MGI
acts upstream of or within locomotion involved in locomotory behavior	IGI IGI: Inferred from genetic interaction	16648267	MGI
acts upstream of or within response to ischemia	IMP IMP: Inferred from mutant phenotype	16648267	MGI
acts upstream of or within response to oxidative stress	IGI IGI: Inferred from genetic interaction	16648267	MGI
acts upstream of or within response to stress	IGI IGI: Inferred from genetic interaction	16648267	MGI
acts upstream of or within response to stress	IMP IMP: Inferred from mutant phenotype	16648267	MGI
acts upstream of or within short-term memory	IGI IGI: Inferred from genetic interaction	16648267	MGI
acts upstream of or within skeletal muscle fiber development	IDA IDA: Inferred from direct assay	16024798	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10722714	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10722714	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

calcipressin-1

calcineurin inhibitor	down syndrome critical region protein 1 homolog
myocyte-enriched calcineurin-interacting protein 1

Rcan1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Rcan1	Q9JHG6	Fmr1	Mus musculus	P35922	FRET	22863780
Intra	Rcan1	Q9JHG6	Dyrk1a	Mus musculus	Q61214	Anti Bait CoIP	21965663

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11779	RCAN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21728	Rcan1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28245	Rcan1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rcan1	NCBI	NCBI:1827

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