2. Gene
  3. Lars1 - leucyl-tRNA synthetase 1 Gene

Lars1 - leucyl-tRNA synthetase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Lars

Gene ID: 291624 | Gene type: protein coding

About Lars1

Summary

Predicted to enable GTPase activator activity; glutamine-tRNA Ligase activity; and leucine-tRNA Ligase activity. Predicted to be involved in several processes, including cellular response to leucine; cellular response to leucine starvation; and tRNA aminoacylation for protein translation. Predicted to be located in several cellular components, including endoplasmic reticulum; lysosome; and nuclear body. Predicted to be part of Aminoacyl-tRNA Synthetase multienzyme complex. Human ortholog(s) of this gene implicated in infantile liver failure syndrome 1. Orthologous to human LARS1 (leucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Lars1 Products(1)

mRNA Protein Name
NM_001009637.1 NP_001009637.1 leucine--tRNA ligase, cytoplasmic
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
27191843 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine--tRNA ligase, cytoplasmic

leucyl-tRNA synthetase, cytoplasmic

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07532 LARS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21627 Lars1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28145 Lars1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lars1 NCBI NCBI:51520