VGLL2 - vestigial like family member 2 Gene

Homo sapiens

Also known as VGL2; VITO1

Gene ID: 245806 | Gene type: protein coding

About VGLL2

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:117,265,558-117,273,630 (from NCBI)

This gene has 2 transcripts (splice variants), 191 orthologues and 2 paralogues. Biased expression in heart (RPKM 1.5), prostate (RPKM 0.6) and 4 other tissues.

Summary

This gene encodes a protein with a transcriptional enhancer factor 1 (TEF-1) interaction domain. The encoded protein may act as a co-factor of TEF-1 regulated gene expression during skeletal muscle development. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

VGLL2 Products(2)

mRNA	Protein	Name
NM_153453.1	NP_703154.1	transcription cofactor vestigial-like protein 2 isoform 2
NM_182645.3	NP_872586.1	transcription cofactor vestigial-like protein 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VGLL2 Protein Structure

Vg_Tdu

0
100
200
317 a.a.

Protein Preferred Names

Protein Names

transcription cofactor vestigial-like protein 2

Vestigial and Tondu related protein 1

Related Diseases

Diseases

Alias

Spindle Cell Rhabdomyosarcoma

Pleomorphic Rhabdomyosarcoma

Adult Pleomorphic Rhabdomyosarcoma	Anaplastic Rhabdomyosarcoma
Pleomorphic Rhabdomyosarcoma, Adult Type

Cellular Congenital Mesoblastic Nephroma

Progressive Relapsing Multiple Sclerosis

Prms	Progressive-Relapsing Ms
Multiple Sclerosis, Progressive Relapsing

Congenital Fibrosarcoma

Infantile Fibrosarcoma

Childhood Fibrosarcoma

Pediatric Fibrosarcoma

Lipofibromatosis-Like Neural Tumor

Smarca4-Deficient Sarcoma Of Thorax

Smarca4-Dts

Smarca4-Deficient Thoracic Sarcoma

Myofibroma

Lipoleiomyoma	Uterine Fibroids
Solitary Myofibromatosis	Myolipoma

Kidney Sarcoma

Renal Sarcoma

Sarcoma Of Kidney

Malignant Pineal Area Germ Cell Neoplasm

Pineal Germ Cell Tumor	Malignant Pineal Parenchymal Germ Cell Tumor
Pineal Region Germ Cell Tumor	Pineal Cell Tumor
Pineal Cell Tumour	Pineal Region Germinoma
Malignant Pineal Region Germ Cell Tumor	Pineal Germinoma

Kidney Clear Cell Sarcoma

Clear Cell Sarcoma Of Kidney	Childhood Kidney Clear Cell Sarcoma
Renal Clear Cell Sarcoma	Ccsk
Clear Cell Sarcoma Of The Kidney

Rhabdomyosarcoma

Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma, Embryonal	Rhabdomyosarcoma Embryonal
Botryoid Rhabdomyosarcoma	Erms
Spindle Cell Rhabdomyosarcomas

Spindle Cell Sarcoma

Sarcoma	Sarcoma Spindle Cell
Sarcoma, Spindle Cell	Sarcoma - Category

Skeletal Muscle Cancer

Malignant Tumor Of Skeletal Muscle

Skeletal Muscle Neoplasm

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma	Rhabdomyosarcoma, Alveolar
Rhabdomyosarcoma Alveolar	RMS2
Rmsa	Rhabdomyosarcoma 2, Alveolar
Alveolar Childhood Rhabdomyosarcoma	Arms
Rhabdomyosarcoma, Type 2

Muscle Cancer

Myosarcoma	Malignant Neoplasm Of Muscle
Malignant Tumor Of Muscle	Malignant Tumor Of The Muscle
Muscle Neoplasms	Myomatous Neoplasm

Craniometaphyseal Dysplasia, Autosomal Dominant

Craniometaphyseal Dysplasia	CMDD
Cmdj	Cmd
Autosomal Dominant Craniometaphyseal Dysplasia	Craniometaphyseal Dysplasia, Jackson Type
Craniometaphyseal Dysplasia Jackson Type	Autosomal Recessive Craniometaphyseal Dysplasia
Cmdr	Dysplasia, Craniometaphyseal, Autosomal Dominant
Craniometaphyseal Dysplasia, Autosomal Recessive Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15645	VGLL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	VGLL2	VGNC	VGNC:102546
Mus musculus	VGLL2	MGD	MGI:2447460
Macaca mulatta	VGLL2	VGNC	VGNC:79237
Canis familiaris	VGLL2	VGNC	VGNC:48258
Rattus norvegicus	VGLL2	RGD	RGD:1311903
Bos taurus	VGLL2	VGNC	VGNC:36791

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