2. Gene
  3. Dtx1 - deltex 1, E3 ubiquitin ligase Gene

Dtx1 - deltex 1, E3 ubiquitin ligase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Fxit1; mKIAA4160

Gene ID: 14357 | Gene type: protein coding

About Dtx1

Summary

Predicted to enable Notch binding activity; ubiquitin protein Ligase activity; and ubiquitin protein Ligase binding activity. Acts upstream of or within several processes, including Notch signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of T cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human DTX1 (deltex E3 ubiquitin Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Dtx1 Products(1)

mRNA Protein Name
NM_008052.3 NP_032078.2 E3 ubiquitin-protein ligase DTX1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11226752 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
11226752 MGI
acts upstream of or within Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
15965470 MGI
acts upstream of T cell differentiation IDA
IDA: Inferred from direct assay
12794108 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within glial cell differentiation IMP
IMP: Inferred from mutant phenotype
15965470 MGI
acts upstream of or within negative regulation of T cell differentiation IDA
IDA: Inferred from direct assay
12794108 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase DTX1

FXI-T1

RING-type E3 ubiquitin transferase DTX1

deltex 1 homolog

deltex1

fractionated x-irradiation induced transcript 1

mDTX1

protein deltex-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-126931 Dinophysistoxin 1 95.00% Unkown
HY-RS04038 DTX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18353 Dtx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24832 Dtx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dtx1 NCBI NCBI:1840