2. Cell Cycle/DNA Damage Cytoskeleton
  3. Folate Receptor (FR) Microtubule/Tubulin DNA Alkylator/Crosslinker
  4. EC-0225

EC-0225, a folate conjugate of two agents- one a potent microtubule inhibiting agent, and the second a DNA alkylating agent. EC-0225 inhibits the growth of folate receptor (FR)-positive KB cells with an IC50 of ~1 nM. EC-0225 can be selectively delivered to advanced FR-positive tumors without causing overt toxicity, such as lung carcinoma.

For research use only. We do not sell to patients.

EC-0225

EC-0225 Chemical Structure

CAS No. : 926626-77-9

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Description

EC-0225, a folate conjugate of two agents- one a potent microtubule inhibiting agent, and the second a DNA alkylating agent. EC-0225 inhibits the growth of folate receptor (FR)-positive KB cells with an IC50 of ~1 nM. EC-0225 can be selectively delivered to advanced FR-positive tumors without causing overt toxicity, such as lung carcinoma[1].

Molecular Weight

2192.51

Formula

C103H130N20O26S4
CAS No.
SMILES

O[C@@]1(CC)C[C@]2([H])C[C@@](C3=C(OC)C=C4C([C@@]5(CC6)[C@@]([C@](C(NNC(OCCSSC[C@H](C(O)=O)CC([C@@H](NC([C@H](NC([C@H](CC(O)=O)NC([C@H](CC)NC(CC[C@@H](C)NC(C7=CC=C(NCC8=CNC(C9=N8)=NC(N)=CC9=O)C=C7)=O)=O)=O)=O)CC(O)=O)=O)CNC(CCSSCCNC%10=C(C)C(C%11=C(C[C@@]%12(OC)N%11C[C@H]%13[C@@H]%12N%13)C%10=O)=O)=O)=O)=O)=O)(O)[C@H](O)[C@@]%14(CC)[C@]5([H])N6CC=C%14)([H])N4C)=C3)(C(OC)=O)C%15=C(CC[N@@](C2)C1)C%16=CC=CC=C%16N%15
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EC-0225 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EC-0225926626-77-9EC0225EC 0225Folate Receptor (FR)Microtubule/TubulinDNA Alkylator/Crosslinkerfolate conjugatemicrotubule inhibiting agentDNA alkylatingfolate receptor (FR)-positive tumorslung carcinomaInhibitorinhibitorinhibit

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