DNK-333 

DNK-333 is a potent and balanced dual NK1 and NK2 receptor antagonist with IC₅₀ values of 4.8 nM and 5.5 nM, respectively. DNK-333 blocks the Neurokinin A (NKA) (HY-P0197)-induced bronchoconstriction in asthma^[1].

DNK-333 exhibits potent and reversible NK1 and NK2 receptor antagonist activities in this assay, with pK_b values of 9.2 and 7.43, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DNK-333 inhibits bronchoconstriction induced by NK1 and NK2 receptor agonists in guinea pigs and squirrel monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

624.40

C₂₇H₂₅Cl₂F₆N₃O₃

398507-81-8

O=C(N([C@H](CC1=CC(Cl)=C(Cl)C=C1)/C=C/C(N[C@H]2C(NCCCC2)=O)=O)C)C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Swarna VM, et al. Design and synthesis of 3,5-disubstituted benzamide analogues of DNK333 as dual NK1/NK2 receptor probes. Bioorg Med Chem Lett. 2007 Feb 15;17(4):890-4.

  [2]. Schelfhout V, et al. The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma. Pulm Pharmacol Ther. 2006;19(6):413-8.