2. Metabolic Enzyme/Protease
  3. MMP
  4. CGS 27023A free base

CGS 27023A free base is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A free base prevents cartilage degradation in stromelysin-induced rabbit cartilage degradation model. CGS 27023A free base can be used for study of arthritis.

For research use only. We do not sell to patients.

CGS 27023A free base

CGS 27023A free base Chemical Structure

CAS No. : 161314-70-1

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CGS 27023A free base Related Antibodies

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Description

CGS 27023A free base is a non-peptidic and orally active MMP inhibitor with the Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A free base prevents cartilage degradation in stromelysin-induced rabbit cartilage degradation model. CGS 27023A free base can be used for study of arthritis[1].

IC50 & Target[1]

MMP-3

43 nM (Ki)

MMP-1

33 nM (Ki)

MMP-2

20 nM (Ki)

MMP-9

8 nM (Ki)

Molecular Weight

393.46

Formula

C18H23N3O5S
CAS No.
SMILES

CC(C)[C@@H](N(S(=O)(C1=CC=C(OC)C=C1)=O)CC2=CC=CN=C2)C(NO)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CGS 27023A free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGS 27023A161314-70-1MMPMatrix metalloproteinasesstromelysin-induced cartilage degradationarthritisInhibitorinhibitorinhibit

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CGS 27023A free base
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