2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. APL-5125

APL-5125 (Compound 61f) is a potent, selective and orally active ATP-competitive CK2α inhibitor with an IC50 of 0.348 nM and a Ki of 0.095 nM. APL-5125 binds to CK2α in a bivalent manner, simultaneously interacting with the ATP-binding site and the αD pocket. APL-5125 exhibits antitumor activity and can be used for the research of cancer, such as colon cancer.

For research use only. We do not sell to patients.

APL-5125

APL-5125 Chemical Structure

CAS No. : 2830619-57-1

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APL-5125 Related Antibodies

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Description

APL-5125 (Compound 61f) is a potent, selective and orally active ATP-competitive CK2α inhibitor with an IC50 of 0.348 nM and a Ki of 0.095 nM. APL-5125 binds to CK2α in a bivalent manner, simultaneously interacting with the ATP-binding site and the αD pocket. APL-5125 exhibits antitumor activity and can be used for the research of cancer, such as colon cancer[1].

IC50 & Target[1]

CK2α

0.348 nM (IC50)

CK2α

0.095 nM (Ki)

In Vivo

APL-5125 (10-100 mg/kg; p.o.; once daily for 21 days) inhibits tumor growth in mice bearing with HCT-116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice bearing with HCT-116 cells[1]
Dosage: 10, 30 and 100 mg/kg
Administration: Oral administration, once daily for 21 days
Result: Showed tumor-growth inhibition with 45% at 100 mg/kg.
Molecular Weight

565.49

Formula

C27H24F5N3O5
CAS No.
SMILES

O=C(O)C1=CC2=NC(OCCOCCCCNCC3=CC(F)=C(OC(F)(F)F)C(F)=C3)=C4C=CN=CC4=C2C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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APL-5125 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APL-51252830619-57-1APL5125APL 5125Casein KinasetumorspreclinicalexposurePK-PDpotencyS129cellularselectivitykinaseHCT116profileCK2αp-AKTdruginhibitorunboundInhibitorinhibit

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