APG-7

Cat. No.: HY-179036: Data Sheet Handling Instructions
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APG-7 binds to the TLR4/MD-2 interface, thereby inhibiting NO production (IC₅₀ of 24.2 μg/mL). APG-7 is an Apigenin (HY-N1201) derivative. APG-7 has low toxicity to the 3T3 fibroblast cell line. APG-7 can be used for the study of oxidative stress and inflammation.

For research use only. We do not sell to patients.

APG-7 Chemical Structure

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

TLR4

In Vitro

APG-7 (25 μg/mL) inhibits the formation of superoxide anion with 29.06% inhibition^[1].
APG-7 (0.1-100 μg/mL; 48 h) showed no toxicity at ∼25 μg/mL on fibroblast cells^[1].
In-silico anti-cancer activity analysis reveals that APG-7 displays anti-cancer activity for B-lymphoblastic cells, colon adenocarcinoma, non-small cell lung carcinoma, and metastatic melanoma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	3T3 fibroblast cells
Concentration:	100 μg/mL, 10 μg/mL, 1.0 μg/mL, 0.1 μg/mL
Incubation Time:	48 h
Result:	Moderately suppressed the production of free radicals. Did not show toxicity up to concentration of 25 μg/mL.

Molecular Weight

578.52

Formula

C₃₀H₂₆O₁₂

SMILES

O[C@@H]1[C@@H](OC2=CC=C(C=C2)C3=CC(C4=C(C=C(C=C4O3)O)O)=O)O[C@@H](COC(/C=C/C5=CC=C(C=C5)O)=O)[C@H](O)[C@@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Soomro S, et al. Apigenin and its derivative modulate nitric oxide production and interfere with TLR4-M2: In-vitro and in-silico insights. Bioorg Chem. Published online October 4, 2025. [Content Brief]

APG-7 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APG-7APG7APG 7Toll-like Receptor (TLR)Oxidative stressTLR4/MD-2Apigenin derivativeNOInhibitorinhibitorinhibit

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