2. Apoptosis
  3. RIP kinase
  4. Anticancer agent 284

Anticancer agent 284 exhibits cytotoxicity against osteosarcoma cell line (Hos), non-small cell lung cancer cell line (A549), and colon cancer cell line (HCT-116). Anticancer agent 284 can impact the pRIPK3 kinase concentration in the A549 (2.97 pg/mL). Anticancer agent 284 can be used for the study of cancer.

For research use only. We do not sell to patients.

Anticancer agent 284

Anticancer agent 284 Chemical Structure

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Anticancer agent 284 Related Antibodies

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Description

Anticancer agent 284 exhibits cytotoxicity against osteosarcoma cell line (Hos), non-small cell lung cancer cell line (A549), and colon cancer cell line (HCT-116). Anticancer agent 284 can impact the pRIPK3 kinase concentration in the A549 (2.97 pg/mL). Anticancer agent 284 can be used for the study of cancer[1].

In Vitro

Anticancer agent 284 (Compound 4) cytotoxic against all the tested cell lines, with an IC50 activity order of HCT-116 (7.3 µM) > A549 (20.4 µM) > Hos (39.9 µM)[1].
Anticancer agent 284 slightly inhibis pRIPK3 in A549 cells (2.97 pg/mL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 284 Related Antibodies

ELISA Assay[1]

Cell Line: A549 human lung cancer cells
Concentration: 20.4 μM (treat with the IC50 concentration of the active compound)
Incubation Time: 24 h
Result: Impacted the pRIPK3 kinase concentration in the A549 (2.97 pg/mL).
Molecular Weight

487.57

Formula

C26H25N5O3S
SMILES

CC1=CC=C(C=C1)S(=O)(N/N=C(C2=CC=C(C=C2)N/C=C3C(N(N=C/3C)C4=CC=CC=C4)=O)\C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Anticancer agent 284 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 284Anticancer agent284Anticancer agent-284RIP kinaseReceptor-interacting protein kinasesRIPKN-benzyl-4-thiazoloneN-benzylthiazoleN-phenylpyrazoloneEdaravoneMTTRIPK3Inhibitorinhibitorinhibit

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