2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. iGluR

iGluR

Ionotropic glutamate receptors

iGluR

Related Products

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iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR Isoform Specific Products:

iGluR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100802
    Homoquinolinic acid
    		Agonist
    Homoquinolinic acid is a non endogenous agonist of NMDAR2 receptor.
    Homoquinolinic acid
  • HY-W724221
    3-Methoxyeticyclidine hydrochloride
    		Ligand
    3-Methoxyeticyclidine hydrochloride is a phencyclidine-type compound that has binding affinity for the N-methyl-D-aspartate receptor. 3-Methoxyeticyclidine hydrochloride has a certain degree of toxicity.
    3-Methoxyeticyclidine hydrochloride
  • HY-114975
    EGIS-8332
    		Antagonist
    EGIS-8332 is a non-competitive AMPA receptor antagonist. EGIS-8332 inhibits AMPA currents in rat cerebellar Purkinje cells and inhibited the AMPA- and Quisqualate-induced excitotoxicity in primary cultures of telencephalon neurons (IC50 = 5.1-9.0 μM). EGIS-8332 exhibits anticonvulsant and neuroprotective effects. EGIS-8332 can be used for the research of neurological disease.
    EGIS-8332
  • HY-107708
    threo-Ifenprodil hemitartrate
    		Antagonist
    threo Ifenprodil hemitartrate is a σ receptor agonist, with Kis of 59.1 and 2 nM for σ1 and σ2 receptors, respectively. threo Ifenprodil hemitartrate is also a NR2B subunit-selective NMDA receptor antagonist (IC50=0.22 μM). threo Ifenprodil hemitartrate is a hERG potassium channel inhibitor, with an IC 50 of 88 nM, showing antiarrhythmic activity.
    threo-Ifenprodil hemitartrate
  • HY-111973S3
    Phaseic acid-d4
    		Antagonist
    Phaseic acid-d4 is the deuterium labeled Phaseic acid. Phaseic acid is a Abscisic acid terpenoid catabolite that can able to activate a subset of Abscisic acid repectors. Phaseic acid is a plant hormone associated with photosynthesis arrest and abscission. Phaseic acid is the antagonist for NMDA-type glutamate receptor (NMDAR) that inhibits NMDAR currents with an IC50 of 34.37 μM. Phaseic acid reduces intracellular calcium influx, and exhibits neuroprotective effect.
    Phaseic acid-d<sub>4</sub>
  • HY-15070
    YM 900
    		Antagonist
    YM 900 is an AMPA receptor antagonist.
    YM 900
  • HY-143391
    NMDA receptor modulator 3
    		Modulator
    NMDA receptor modulator 3 (Compound 99) is a potent NMDA receptor modulator. NMDA receptor modulator 3 can be used for neurological disorder research.
    NMDA receptor modulator 3
  • HY-105413
    L-703717
    		Antagonist
    L-703717 is a NMDA receptor antagonist. L-703717 preferentially binds to cerebellar-specific NMDA receptors consisting of a GluRepsilon3 subunit and eventually accumulates in rodent cerebellum. L-703717 can be used for the research of neurological disease.
    L-703717
  • HY-175508
    NMDA receptor modulator 9
    		Agonist
    NMDA receptor modulator 9 is an orally active NMDA receptor positive allosteric modulator (PAM). NMDA receptor modulator 9 enhances GluN2A receptor activity. NMDA receptor modulator 9 demonstrates significant antidepressant-like effects in chronic restraint stress (CRS)-induced depression mice. NMDA receptor modulator 9 can be used for the study of depression.
    NMDA receptor modulator 9
  • HY-13993B
    Ro 25-6981 hydrochloride
    		Antagonist
    Ro 25-6981 hydrochloride is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 hydrochloride shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 hydrochloride has the potential for the research of parkinson's disease (PD).
    Ro 25-6981 hydrochloride
  • HY-124204
    LY 274614
    		Antagonist
    LY 274614 is an orally active, competitive NMDA receptor antagonist. LY 274614 can be used for Neurological Disease study.
    LY 274614
  • HY-105340
    MDL 27266
    		Antagonist
    MDL 27266 is an orally active NMDA receptor antagonist with neuroprotective effect. MDL 27266 is a broad-spectrum anticonvulsant agent.
    MDL 27266
  • HY-173623
    EU 1622-240
    		Activator
    EU 1622-240 is a biased positive allosteric modulator of GluN2B, GluN2C, and GluN2D, with EC50s of 0.57, 0.82, 1.1 μM respectively. EU 1622-240 has good physicochemical properties, in vitro stability, and permeability.
    EU 1622-240
  • HY-B0591S
    Memantine-d3 hydrochloride
    		Antagonist
    Memantine-d3 (hydrochloride) is deuterium labeled Memantine. Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD).
    Memantine-d<sub>3</sub> hydrochloride
  • HY-107031
    Metapramine
    		Antagonist
    Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel.
    Metapramine
  • HY-148611
    NSC339614 potassium
    NSC339614 potassium is a selective GluN1/GluN2C and GluN1/GluN2D receptor enhancer with the activity of enhancing neuronal responses to specific NMDA receptors. NSC339614 potassium can selectively enhance the signaling of GluN1/GluN2C and GluN1/GluN2D receptors without affecting other NMDA receptors. The mechanism of action of NSC339614 potassium does not compete with agonists of L-glutamate or glycine, nor does it depend on membrane potential. The activity of NSC339614 potassium depends on the specific structure of the agonist ligand binding domain, showing its potential as a novel pharmacological agent for studying the function of NMDA receptor subtypes and providing new lead compounds for a variety of neurological diseases.
    NSC339614 potassium
  • HY-P1058
    Pep2m
    		Inhibitor
    Pep2m is a peptide receptor inhibitor. Pep2m inhibits the interaction between the C-terminus of the AMPA-type glutamate receptor (GluA2) subunit and N-ethylmaleimide-sensitive fusion protein (NSF). Pep2m prevents synaptic long-term depression (LTD). Pep2m can reduce postsynaptic currents in neurons, AMPA-mediated currents in cultured hippocampal neurons, and AMPA receptor surface expression[1][2][3][4][5].
    Pep2m
  • HY-137049
    Co 101244
    Co-101244 (PD 174494) is an NMDA receptor blocker that specifically targets the NR2B subunit.
    Co 101244
  • HY-15078
    NS1219
    NS1219 ((R)-SPD502) is the isomer of NS 1209 HY-15074. NS1209 is a selective AMPA receptor antagonist with neuroprotective activity. NS1209 can be used for the research of stroke, neuropathic pain and epilepsy.
    NS1219
  • HY-100356
    Aptiganel
    		Antagonist
    Aptiganel (CNS 1102 (free base)), peptide, is a noncompetitive NMDA antagonist with cerebroprotective effects. Aptiganel can be used for the research of stroke.
    Aptiganel
Cat. No. Product Name / Synonyms Application Reactivity
iGluR Isoform Comparison

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