RIP kinase

RIP kinase Related Products (87):

By Effects:	Control (1) Inhibitors (79) Activators (6) Degrader (1)

Cat. No.	Product Name	Effect	Purity

HY-155151

RIPK2/3-IN-1	Inhibitor
RIPK2/3-IN-1 is a potent dual RIPK2/3 kinases inhibitor with IC₅₀ values of 3 nM and 117 nM, respectively. RIPK2/3-IN-1 is against RIPK2 with IC₅₀ value 14 nM in 14-TriLAN-Gly/NOD1 THP-1 cell-based NF-κB reporter assay.

HY-156368

RIPK3-IN-4	Inhibitor
RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor. RIPK3-IN-4 inhibits HK-2 cell damage, necroptosis and inflammatory responses. RIPK3-IN-4 reduces Cisplatin (HY-17394)- and I/R-induced kidney damage, inflammatory response and necroptosis in acute kidney injury.

HY-RS11994

Ripk1 Rat Pre-designed siRNA Set A	Inhibitor
Ripk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ripk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-153436

RIP1 kinase inhibitor 6	Inhibitor
RIP1 kinase inhibitor 6 is a potent and selective RIP1 kinase inhibitor with an IC₅₀ of < 100 nM in human R1P1 kinase assay. RIP1 kinase inhibitor 6 is extracted from patent WO2020103884, example 80.

HY-157751

RIPK1-IN-21	Inhibitor
RIPK1-IN-21 (Compound I-5) is an inhibitor of RIPK1 with an EC₅₀ value of 14.8 nM. RIPK1-IN-21 can be used in the research of neurodegenerative, autoimmune, and inflammatory diseases.

HY-163390

RIP1 kinase inhibitor 9	Inhibitor
RIP1 kinase inhibitor 9 (compound SY-1) is a selective RIP kinase inhibitor. RIP1 kinase inhibitor 9 effectively suppresses the central inflammatory response induced by epilepsy. RIP1 kinase inhibitor 9 inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis in HT-29 cells with an EC₅₀ of 7.04 nM.

HY-168640

RIP3 activator 1	Activator
RIP3 activator 1 (compound C8) is a potent RIP3 activator. RIP3 activator 1 inhibits cell growth. RIP3 activator 1 induces necroptosis through the RIP3/p62/Keap1 signaling pathway. RIP3 activator 1 increases the protein expression of p-MLKL. RIP3 activator 1 induces autophagy. RIP3 activator 1 increases accumulation of LC3-II and p62 protein expression.

HY-168974

Fosizensertib	Inhibitor
Fosizensertib is the inhibitor for RIP-1 kinase and can be used in researchs of ulcerative colitis.

HY-146694

RIPK2-IN-1	Inhibitor
RIPK2-IN-1 (compound 18f) is a potent RIPK2 inhibitor with an IC₅₀ of 51 nM. RIPK2-IN-1 inhibits ALK2 with an IC₅₀ of 5 nM. RIPK2-IN-1 has an IC₅₀ of 390 nM on RIPK2/NOD2 in cell assay.

HY-143480

RIPK1-IN-15	Inhibitor
RIPK1-IN-15 (Compound 2.5) is a potent inhibitor of RIPK1. RIPK1-IN-15 has the potential for the research neurodegenerative, autoimmune, and inflammatory diseases.

HY-168116

RIPK1-IN-27	Inhibitor
RIPK1-IN-27 (compund 19) is a RIPK1 inhibitor.

HY-160216A

RIPK1-IN-18 sulfate hydrate	Inhibitor
RIPK1-IN-18 sulfate hydrate is a potent RIPK1 inhibitor that can be used in autoimmune diseases research (NZ748385A; compound i).

HY-157309

RIPK2-IN-4	Inhibitor
RIPK2-IN-4 is a potent and specific RIPK2 inhibitor with an IC₅₀ value of 5 nM.

HY-RS11999

Ripk3 Mouse Pre-designed siRNA Set A	Inhibitor
Ripk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ripk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-162928

RIPK1-IN-26	Inhibitor
RIPK1-IN-26 (Compound 8a) is a potent receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor with cell anti-necroptosis potency. RIPK1-IN-26 demonstrats good metabolic stability and good binding specificity in mice. RIPK1-IN-26 is promising for research of PET imaging probe development and neurodegenerative disorders.

HY-120600

Sibiriline	Inhibitor
Sibiriline is a specific competitive inhibitor of RIPK1 that targets the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis, but does not protect cells from caspase-dependent apoptosis. Sibiriline protects mice from concanavalin A-induced hepatitis and has the potential to inhibit immune-dependent hepatitis..

HY-161843

Necroptosis-IN-4	Inhibitor
Necroptosis-IN-4, a potent necroptosis inhibitor, is a RIP kinase 1 (RIPK1) inhibitor. Necroptosis-IN-4 has no inhibitory activity against RIPK3 and weak inhibitory activity against VEGFR1/2 and PDGFR-α.

HY-148253

TP-030-1	Inhibitor
TP-030-1, a chemical probe, is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a K_i value of 3.9 nM and inhibits mRIPK1 with an IC₅₀ value of 4.2 μM. TP-030-1 can be used for the research of inflammatory diseases and neurodegenerative diseases.

HY-168567

RIPK2-IN-6	Inhibitor
RIPK2-IN-6 (Compound 15a) is an inhibitor for RIPK, that inhibits the phosphorylation of RIPK2, and thus inhibits the NF-κB and MAPK signaling pathways. RIPK2-IN-6 exhibits anti-inflammatory and anti-fibrotic activities in Dextran sodium sulfate (HY-116282C)-induced mice colitis models.

HY-173075

Anticancer agent 267	Activator
Anticancer agent 267 (Compound 5q) is the activator for RIPK3 and MLKL. Anticancer agent 267 inhibits the proliferation in a variety of cancer cell lines (IC₅₀ for MDA-MB-231, MDA-MB-486 and MCF-7 is 9.79, 10.77 and 5.94 μM, respectively), arrests cell cycle at subG1 phase, and induces necroptosis in cell MDA-MB-231. Anticancer agent 267 exhibits antitumor activity in mouse xenograft models.

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