2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. NKCC
  5. NKCC Antagonist

NKCC Antagonist

NKCC Antagonist (1):

Cat. No. Product Name Effect Purity
  • HY-115606
    ML077
    		Antagonist
    ML007 is a selective antagonist targeting the neuron-specific potassium-chloride co-transporter 2 (KCC2) with an IC50 for KCC2 is 537 nM, while its inhibitory activity on KCC1 is extremely weak (IC50 > 50 μM). ML077 inhibits the chloride ion excretion function of KCC2, increasing the intracellular chloride ion concentration, thereby enhancing the depolarization mediated by chloride ion channels. ML007 can promote glucose-stimulated insulin secretion (GSIS) without relying on KATP channels. ML007 can be used to study the functions related to pain, epilepsy, and insulin secretion.